Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Samuel G Usher"'
Publikováno v:
eLife, Vol 9 (2020)
Pancreatic ATP-sensitive K+ channels (KATP) comprise four inward rectifier subunits (Kir6.2), each associated with a sulphonylurea receptor (SUR1). ATP/ADP binding to Kir6.2 shuts KATP. Mg-nucleotide binding to SUR1 stimulates KATP. In the absence of
Externí odkaz:
https://doaj.org/article/03955459d3cc4cbbaa1a59ccc81000a1
Autor:
Tanadet Pipatpolkai, Samuel G. Usher, Natascia Vedovato, Frances M. Ashcroft, Phillip J. Stansfeld
Publikováno v:
Pipatpolkai, T, Usher, S G, Vedovato, N, Ashcroft, F M & Stansfeld, P J 2022, ' The dynamic interplay of PIP 2 and ATP in the regulation of the K ATP channel ', The Journal of Physiology, vol. 600, no. 20, pp. 4503-4519 . https://doi.org/10.1113/JP283345
KEY POINTS: The KATP channel is activated by the binding of phosphoinositol-bisphosphate (PIP2 ) lipids and inactivated by the binding of adenosine triphosphate (ATP). K39 has the potential to bind to both PIP2 and ATP. A mutation to this residue (K3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f11a334096095b3567a7a9f7373d65
https://doi.org/10.1101/2021.05.06.442933
https://doi.org/10.1101/2021.05.06.442933
