Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Samuel F. Schluter"'
Publikováno v:
Developmental & Comparative Immunology. 37:176-183
In a recent publication we demonstrated that somatic hypermutation occurs in the V region of the TCR γ gene of the sandbar shark ( Carcharhinus plumbeus ). We hypothesize that similar mechanisms are used to generate somatic mutations in both immunog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00d13dc9ebd98d9b5b502dac3217a7a
https://doi.org/10.1016/j.dci.2011.08.018
https://doi.org/10.1016/j.dci.2011.08.018
Publikováno v:
Developmental & Comparative Immunology. 34:189-195
Beta 2 microglobulin (beta2m) is an essential subunit of major histocompatibility complex (MHC) type I molecules. In this report, beta2m cDNAs were identified and sequenced from sandbar shark spleen cDNA library. Sandbar shark beta2m gene encodes one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84043248535394713ab04224fe7b9d8
https://doi.org/10.1016/j.dci.2009.09.008
https://doi.org/10.1016/j.dci.2009.09.008
Autor:
Samuel F. Schluter, Kevin Lau, Hao Chen, Roman Covarrubias, Ingvill Jensen, John J. Marchalonis, Sarika Kshirsagar
Publikováno v:
Proceedings of the National Academy of Sciences. 106:8591-8596
Ig and T cell receptor (TCR) genes consist of separate genomic elements, which must undergo rearrangement and joining before a functional protein can be expressed. Considerable plasticity in the genomic arrangement of these elements has occurred duri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d969a4b9a8b35832551fd9c269523985
https://doi.org/10.1073/pnas.0811283106
https://doi.org/10.1073/pnas.0811283106
Publikováno v:
Critical Reviews™ in Immunology. 27:221-232
Although the manifestation of inflammatory autodestructive disease is the result of major immunological dysfunction, recent evidence indicates that the immune system attempts to compensate by the production of immunomodulatory autoantibodies. Healthy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd82a85c01354ddf1415de593a5c3e64
https://doi.org/10.1615/critrevimmunol.v27.i3.30
https://doi.org/10.1615/critrevimmunol.v27.i3.30
Publikováno v:
Developmental & Comparative Immunology. 30:223-247
All jawed vertebrates contain the genetic elements essential for the function of the adaptive/combinatorial immune response, have diverse sets of natural antibodies resulting from segmental gene recombination, express comparable functional repertoire
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f10d8dcac8a739903efa7bce32fdc38
https://doi.org/10.1016/j.dci.2005.06.011
https://doi.org/10.1016/j.dci.2005.06.011
Autor:
Douglas F. Larson, Ramón Tomás Sepúlveda, Samuel F. Schluter, Ronald R. Watson, John J. Marchalonis
Publikováno v:
Annals of the New York Academy of Sciences. 1057:247-259
The operation of the immune system is a complex orchestration of specific self and non-self-recognition capacities mediated by cells of the innate system acting in coordination with T and B lymphocytes in a series of processes modulated by cytokines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ba6ad0bf6799cc5752915f01aeca54
https://doi.org/10.1196/annals.1356.019
https://doi.org/10.1196/annals.1356.019
Publikováno v:
The FASEB Journal. 17:1-17
The recombination-activating genes (RAG) encode a site-specific recombinase that is centrally responsible for the rearrangement of genomic V(D)J exons necessary to form functional immunoglobulin and T-cell receptor genes. To help elucidate the origin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a6aa207d3e2556150c805bec388cea
https://doi.org/10.1096/fj.02-0565fje
https://doi.org/10.1096/fj.02-0565fje
Publikováno v:
Developmental & Comparative Immunology. 26:11-26
That the plasma concentration of certain divalent cations change during an inflammatory insult provides a major host defense response in vertebrate animals. This study was designed to investigate the involvement of iron sequestration in invertebrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611cb5d97597d3005a1bf91a7992b976
https://doi.org/10.1016/s0145-305x(01)00051-9
https://doi.org/10.1016/s0145-305x(01)00051-9
This chapter discusses evolutionary factors regarding the emergence and phylogenetic distribution of the innate immune system and the combinatorial or adaptive immune system, as well as the interactions between the two. Naturally occurring IgM antibo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07a4268bf50b08eca1ae0f78aa279123
https://doi.org/10.1128/9781555817671.ch1
https://doi.org/10.1128/9781555817671.ch1
Publikováno v:
Journal of Molecular Recognition. 14:110-121
This review considers definitions of the specificity of antibodies including the development of recent concepts of recognition polyspecificity and epitope promiscuity. Using sets of homologous and unrelated peptides derived from the sequences of immu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e2b3a81a3567e097b09ccedeb54aed
https://doi.org/10.1002/jmr.527
https://doi.org/10.1002/jmr.527