Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Samuel Edward Mann"'
Publikováno v:
Org. Biomol. Chem.. 10:162-170
Four-component reactions between amino alcohols, aldehydes, isocyanides and thiols proceed rapidly under microwave or conventional heating at 60 °C in methanol. The reaction is successful with a wide range of components and gives access to potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3628933eae38670dd0c28a4c70c0157c
https://doi.org/10.1039/c1ob06534c
https://doi.org/10.1039/c1ob06534c
Autor:
Robert Heald, Bryan K. Chan, Stephen Schmidt, Richard L. Elliott, Michael D. Lainchbury, Hans E. Purkey, Ivana Yen, Timothy P. Heffron, Charles Eigenbrot, Jennafer Dotson, Gabriele Schaefer, Hank La, Eileen Mary Seward, Emily J. Hanan, Daniel J. Burdick, Yuan Chen, Samuel Edward Mann, Philip Stephen Jackson, Christine Yu, Shumei Wang, Shiva Malek, Marian C. Bryan, Saundra Clausen, Steve Sideris
The rapid advancement of a series of noncovalent inhibitors of T790M mutants of EGFR is discussed. The optimization of pyridone 1, a nonselective high-throughput screening hit, to potent molecules with high levels of selectivity over wtEGFR and the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bff0d98dceef4d07b28cd023958d6531
https://europepmc.org/articles/PMC4716594/
https://europepmc.org/articles/PMC4716594/
Publikováno v:
Organometallics. 30:1772-1775
The Pd-mediated oxidation of unsaturated thioacetals gives either allyl or vinyl esters, depending on the substrate structure. We report the characterization of a range of sulfur-stabilized palladium intermediates via a combined computational and exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e58936d59414ad2888712bc5acddb583
https://doi.org/10.1021/om2000585
https://doi.org/10.1021/om2000585
Autor:
Alastair H. Kyle, Jennifer H.E. Baker, Judit Banaáth, Samuel Edward Mann, Andrew I. Minchinton, Keith Allan Menear, Karen H. Fryer, Taixiang Wang, Soraya S. Porres, George Hynd
Publikováno v:
Molecular Cancer Therapeutics. 17:A110-A110
Targeting tumor hypoxia continues to be a goal of translational radiation oncology owing to overwhelming preclinical and clinical validation of the importance of tumor oxygenation to radiation sensitivity. We describe a rational, structure-based drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87a1792c4f5af031abe5a7051205d36e
https://doi.org/10.1158/1535-7163.targ-17-a110
https://doi.org/10.1158/1535-7163.targ-17-a110
Publikováno v:
ChemInform. 46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12f7d702ce57b528d37a97b05ff40238
https://doi.org/10.1002/chin.201550216
https://doi.org/10.1002/chin.201550216
Autor:
Krista K. Bowman, Hans E. Purkey, Bryan K. Chan, Michael D. Lainchbury, Belen Dominguez-Fernandez, Robert Heald, Eileen Mary Seward, Stephen P. Schmidt, Mark Merchant, Lily Shao, Kuen Yeap, Saundra Clausen, Emily Chan, Daniel J. Burdick, Yuan Chen, Charles Eigenbrot, Gabriele Schaefer, Steve Sideris, Philip Stephen Jackson, Samuel Edward Mann, Ivana Yen, Richard L. Elliott, Kyle Mortara, Timothy P. Heffron, Hank La, Marian C. Bryan, Christine Yu, Shiva Malek, Jamie D. Knight, Hanan Emily, Shumei Wang
Publikováno v:
Journal of medicinal chemistry. 58(22)
Because of their increased activity against activating mutants, first-generation epidermal growth factor receptor (EGFR) kinase inhibitors have had remarkable success in treating non-small-cell lung cancer (NSCLC) patients, but acquired resistance, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d35671f7efc64173278adb957d251e6f
https://pubmed.ncbi.nlm.nih.gov/26967667
https://pubmed.ncbi.nlm.nih.gov/26967667
Publikováno v:
Inflammation Research. 59:231-233
The effects of the endogenous antioxidant alpha-lipoic acid on guinea pig colon smooth muscle contraction (Gpcc) induced by hydrogen peroxide were examined. Having previously shown that the histone deacetylase (HDAC) benzamide inhibitor MGCD0103 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d98254f321c7be307bc91f4c51f6aa26
https://doi.org/10.1007/s00011-009-0136-1
https://doi.org/10.1007/s00011-009-0136-1
Autor:
Lily Shao, Gabriele Schaefer, Belen Dominguez-Fernandez, Krista K. Bowman, Robert Heald, Jamie D. Knight, Timothy P. Heffron, Christine Yu, Mark Merchant, Stephen P. Schmidt, Kuen Yeap, Kyle Mortara, Charles Eigenbrot, Hank La, Michael Lainchbury, Ivana Yen, Daniel J. Burdick, Eileen Mary Seward, Yuan Chen, Saundra Clausen, Bryan K. Chan, Shiva Malek, Richard L. Elliott, Hanan Emily, Shumei Wang, Hans E. Purkey, Philip Stephen Jackson, Marian C. Bryan, Emily Chan, Samuel Edward Mann, Steve Sideris
Publikováno v:
Journal of Medicinal Chemistry. 59:2848-2848
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58c972dae98703003aebe8beae61e894
https://doi.org/10.1021/acs.jmedchem.6b00301
https://doi.org/10.1021/acs.jmedchem.6b00301
Publikováno v:
ChemInform. 43
Four-component reactions between amino alcohols, aldehydes, isocyanides and aromatic thiols provide arylthioalkylamino acid amides (18 examples) under microwave heating.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dbbaafd8153688960e32ccf3bd548ece
https://doi.org/10.1002/chin.201218045
https://doi.org/10.1002/chin.201218045
Autor:
Kenneth D. M. Harris, Samuel Edward Mann, Aisha S. Rahman, Paul F. McMillan, Colan E. Hughes, Furio Corà, Dinu Iuga, Abil E. Aliev
Publikováno v:
The journal of physical chemistry. A. 115(44)
High-resolution solid-state (2)H MAS NMR studies of the α and γ polymorphs of fully deuterated glycine (glycine-d(5)) are reported. Analysis of spinning sideband patterns is used to determine the (2)H quadrupole interaction parameters, and is shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2317c00c1eebced104dbb5b22df48a0
https://pubmed.ncbi.nlm.nih.gov/21939265
https://pubmed.ncbi.nlm.nih.gov/21939265