Zobrazeno 1 - 2
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pro vyhledávání: '"Samuel Edmondson"'
Publikováno v:
The Journal of Immunology. 173:3647-3652
The maintenance of tolerance is likely to rely on the ability of a T cell to polarize surface molecules providing “help” to only specific APCs. The formation of a mature immunological synapse leads to concentration of the TCR at the APC interface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a539e5dbb8e47d365fc8f352f2de9da
https://doi.org/10.4049/jimmunol.173.6.3647
https://doi.org/10.4049/jimmunol.173.6.3647
Autor:
Abul K. Abbas, Douglas Dresnek, Matthew F. Krummel, Kimberly C. Howland, Samuel Edmondson, Pietro G. Andres
Publikováno v:
The Journal of Immunology. 172:5880-5886
T cell recognition of peptide-MHC complexes on APCs results in the aggregation of TCRs at a central supramolecular activation complex (c-SMAC) within a mature immunological synapse. T cells require a second “costimulatory” signal for activation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d84ee7d8e5ddba48c81cc0be9aa1cc4
https://doi.org/10.4049/jimmunol.172.10.5880
https://doi.org/10.4049/jimmunol.172.10.5880