Single-molecule fluorescence in-situ hybridization reveals that human SHANK3 mRNA expression varies during development and in autism-associated SHANK3 heterozygosity

Autor: Samuel E. Taylor, Ruth D. Taylor, Jack Price, Laura C. Andreae

Publikováno v: Stem Cell Research & Therapy, Vol 9, Iss 1, Pp 1-9 (2018)

Abstract Background Deletions and mutations in the SHANK3 gene are strongly associated with autism spectrum disorder and underlie the autism-associated disorder Phelan–McDermid syndrome. SHANK3 is a scaffolding protein found at the post-synaptic me

Externí odkaz: https://doaj.org/article/bc7203701d5b4f679027d2a1b382f843

Δ9-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons

Autor: Samuel E. Taylor, Lucia Dutan, Laura C. Andreae, Sagnik Bhattacharyya, Deepak Srivastava, Noel J. Buckley, Carole Shum, Jack Price, Ruth D. Taylor, Katherine Warre-Cornish, Emily Annuario

Publikováno v: Shum, C, Dutan, L, Annuario, E, Warre-Cornish, K, Taylor, S E, Taylor, R D, Andreae, L C, Buckley, N J, Price, J, Bhattacharyya, S & Srivastava, D P 2020, ' Δ 9-tetrahydrocannabinol and 2-AG decreases neurite outgrowth and differentially affects ERK1/2 and Akt signaling in hiPSC-derived cortical neurons ', Molecular and Cellular Neuroscience, vol. 103, 103463 . https://doi.org/10.1016/j.mcn.2019.103463

Endocannabinoids regulate different aspects of neurodevelopment. In utero exposure to the exogenous psychoactive cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC), has been linked with abnormal cortical development in animal models. However, much less i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4df105b5023a37b446741b8654cb892
https://doi.org/10.1016/j.mcn.2019.103463

∆9-tetrahydrocannabinol negatively regulates neurite outgrowth and Akt signaling in hiPSC-derived cortical neurons

Autor: Carole Shum, Lucia Dutan, Emily Annuario, Katherine Warre-Cornish, Samuel E. Taylor, Ruth D. Taylor, Laura C. Andreae, Noel J. Buckley, Jack Price, Sagnik Bhattacharyya, Deepak P. Srivastava

Endocannabinoids regulate different aspects of neurodevelopment. In utero exposure to the exogenous psychoactive cannabinoid Δ9-tetrahydrocannabinol (Δ9-THC), has been linked with abnormal cortical development in animal models. However, much less i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b02da6e06228ea694ccbb0ab2df01a6b
https://doi.org/10.1101/440909

Rod microglia: elongation, alignment, and coupling to form trains across the somatosensory cortex after experimental diffuse brain injury

Autor: Tuoxin Cao, Jonathan Lifshitz, Samuel E. Taylor, Jenna M. Ziebell, Jordan L. Harrison

Publikováno v: Journal of Neuroinflammation, Vol 9, Iss 1, p 247 (2012)
Journal of Neuroinflammation

Background Since their discovery, the morphology of microglia has been interpreted to mirror their function, with ramified microglia constantly surveying the micro-environment and rapidly activating when changes occur. In 1899, Franz Nissl discovered

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239f02e3dc6049043262193c09224702
http://www.jneuroinflammation.com/content/9/1/247

Understanding and correcting the spurious interactions in charged supercells

Autor: Samuel E. Taylor, Fabien Bruneval

Publikováno v: Physical Review B. 84

The supercell technique is widely spread for the simulation of charged point defects. Charged defects in a supercell are unfortunately subjected to spurious image interactions, which are usually handled by introducing two correcting terms: a Madelung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::141a8152f496ae0cca71aa2d27d237c7
https://doi.org/10.1103/physrevb.84.075155