Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Samuel E Weinberg"'
Autor:
William W Wheaton, Samuel E Weinberg, Robert B Hamanaka, Saul Soberanes, Lucas B Sullivan, Elena Anso, Andrea Glasauer, Eric Dufour, Gokhan M Mutlu, GR Scott Budigner, Navdeep S Chandel
Publikováno v:
eLife, Vol 3 (2014)
Recent epidemiological and laboratory-based studies suggest that the anti-diabetic drug metformin prevents cancer progression. How metformin diminishes tumor growth is not fully understood. In this study, we report that in human cancer cells, metform
Externí odkaz:
https://doaj.org/article/ab1cc35411e44f338acc368baee076d9
Characterization of hyperpolarization-activated cyclic nucleotide-gated channels in oligodendrocytes
Autor:
Kyle A. Lyman, Ye Han, Andrew P. Robinson, Samuel E. Weinberg, Daniel W. Fisher, Robert J. Heuermann, Reagan E. Lyman, Dong Kyu Kim, Andreas Ludwig, Navdeep S. Chandel, Mark D. Does, Stephen D. Miller, Dane M. Chetkovich
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 18 (2024)
Mature oligodendrocytes (OLG) are the myelin-forming cells of the central nervous system. Recent work has shown a dynamic role for these cells in the plasticity of neural circuits, leading to a renewed interest in voltage-sensitive currents in OLG. H
Externí odkaz:
https://doaj.org/article/c67dec0a15aa414d882f60a7225696ea
Autor:
Gregory S. McElroy, Ram P. Chakrabarty, Karis B. D’Alessandro, Karthik Vasan, Jerica Tan, Joshua S. Stoolman, Samuel E. Weinberg, Elizabeth M. Steinert, Paul A. Reyfman, Benjamin D. Singer, Warren C. Ladiges, Lin Gao, José Lopéz-Barneo, G. R. Scott Budinger, Navdeep S. Chandel
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Aging in mammals leads to reduction in genes encoding the 45-subunit mitochondrial electron transport chain complex I. It has been hypothesized that normal aging and age-related diseases such as Parkinson’s disease are in part due to modes
Externí odkaz:
https://doaj.org/article/60fed24d6ad7416e898540e89de1e6c5
Autor:
Dongkyun Kim, Nagendra Kumar Rai, Amy Burrows, Sohee Kim, Ajai Tripathi, Samuel E. Weinberg, Ranjan Dutta, Ganes C. Sen, Booki Min
Publikováno v:
The Journal of Immunology. 210:721-731
Besides antiviral functions, type I IFN expresses potent anti-inflammatory properties and is being widely used to treat certain autoimmune conditions, such as multiple sclerosis. In a murine model of multiple sclerosis, experimental autoimmune enceph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1f0c6f2c75eb4b549a69cd379552776
https://doi.org/10.4049/jimmunol.2200746
https://doi.org/10.4049/jimmunol.2200746
Publikováno v:
EClinicalMedicine, Vol 26, Iss , Pp 100475- (2020)
Background: The outbreak of coronavirus disease 2019 (COVID-19) in December 2019 overlaps with the flu season. Methods: We compared clinical and laboratory results from 719 influenza and 973 COVID-19 patients from January to April 2020. We compiled l
Externí odkaz:
https://doaj.org/article/4df831bb916049f4af1140faf8a9f20a
Autor:
Manan M. Mehta, Samuel E. Weinberg, Elizabeth M. Steinert, Krishan Chhiba, Carlos Alberto Martinez, Peng Gao, Harris R. Perlman, Paul Bryce, Nissim Hay, Navdeep S. Chandel
Publikováno v:
Cancer & Metabolism, Vol 6, Iss 1, Pp 1-18 (2018)
Abstract Background T cells and cancer cells utilize glycolysis for proliferation. The hexokinase (1–4) family of enzymes catalyze the first step of glycolysis. Hexokinase 2 (HK2) is one of the most highly upregulated metabolic enzymes in both canc
Externí odkaz:
https://doaj.org/article/84278dafdee54bb999a4ec239b5afd5a
Autor:
Zheng Fu, Jian Ye, Joseph W. Dean, John W. Bostick, Samuel E. Weinberg, Lifeng Xiong, Kristen N. Oliff, Zongming E. Chen, Dorina Avram, Navdeep S. Chandel, Liang Zhou
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 159-171.e4 (2019)
Summary: Regulatory T cells (Tregs) are pivotal for immune suppression. Cellular metabolism is important for Treg homeostasis and function. However, the exact role of mitochondrial respiration in Tregs remains elusive. Mitochondrial transcription fac
Externí odkaz:
https://doaj.org/article/276c3dc56b3c4c37a58c0cf7c0a6e7ec
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 451-459 (2016)
Hypoxia-inducible factors (HIFs) are crucial for cellular and organismal adaptation to hypoxia. The mitochondrial respiratory chain is the largest consumer of oxygen in most mammalian cells; however, it is unknown whether the respiratory chain is nec
Externí odkaz:
https://doaj.org/article/d991e3c505c340fd92157ca6287bc356
Publikováno v:
Molecules, Vol 26, Iss 1, p 31 (2020)
Chronic inflammation is one of the most common and well-recognized risk factors for human cancer, including colon cancer. Inflammatory bowel disease (IBD) is defined as a longstanding idiopathic chronic active inflammatory process in the colon, inclu
Externí odkaz:
https://doaj.org/article/e508395645f448e9ab353e184be2f079
Autor:
Elena, Montauti, Samuel E, Weinberg, Peng, Chu, Shuvam, Chaudhuri, Nikita L, Mani, Radhika, Iyer, Yuanzhang, Zhou, Yusi, Zhang, Changhong, Liu, Chen, Xin, Shana, Gregory, Juncheng, Wei, Yana, Zhang, Wantao, Chen, Zhaolin, Sun, Ming, Yan, Deyu, Fang
Publikováno v:
Science advances. 8(47)
The tumor microenvironment (TME) enhances regulatory T (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32b9e112037c1a69eef1a010d4df618e
https://pubmed.ncbi.nlm.nih.gov/36427305
https://pubmed.ncbi.nlm.nih.gov/36427305