Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Samuel E, Jones"'
Autor:
Junxi Liu, Rebecca C. Richmond, Emma L. Anderson, Jack Bowden, Ciarrah-Jane S. Barry, Hassan S. Dashti, Iyas S. Daghlas, Jacqueline M. Lane, Simon D. Kyle, Céline Vetter, Claire L. Morrison, Samuel E. Jones, Andrew R. Wood, Timothy M. Frayling, Alison K. Wright, Matthew J. Carr, Simon G. Anderson, Richard A. Emsley, David W. Ray, Michael N. Weedon, Richa Saxena, Martin K. Rutter, Deborah A. Lawlor
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Self-reported shorter/longer sleep duration, insomnia, and evening preference are associated with hyperglycaemia in observational analyses, with similar observations in small studies using accelerometer-derived sleep traits. Mendelian random
Externí odkaz:
https://doaj.org/article/7570bd5e2c7049fda1219de8ef4b9840
Autor:
Satu Strausz, Erik Abner, Grace Blacker, Sarah Galloway, Paige Hansen, Qingying Feng, Brandon T. Lee, Samuel E. Jones, Hele Haapaniemi, Sten Raak, George Ronald Nahass, Erin Sanders, FinnGen, Estonian Genome Centre, Estonian Biobank Research Team, Pilleriin Soodla, Urmo Võsa, Tõnu Esko, Nasa Sinnott-Armstrong, Irving L. Weissman, Mark Daly, Tuomas Aivelo, Michal Caspi Tal, Hanna M. Ollila
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Lyme disease is a tick-borne disease caused by bacteria of the genus Borrelia. The host factors that modulate susceptibility for Lyme disease have remained mostly unknown. Using epidemiological and genetic data from FinnGen and Estonian Biob
Externí odkaz:
https://doaj.org/article/6ff1c773b86b466eacdd4659aaa166eb
Autor:
Matthew O. Goodman, Hassan S. Dashti, Jacqueline M. Lane, Daniel P. Windred, Angus Burns, Samuel E. Jones, Tamar Sofer, Shaun M. Purcell, Xiaofeng Zhu, Hanna M. Ollila, Simon D. Kyle, Kai Spiegelhalder, Yuksel Peker, Tianyi Huang, Sean W. Cain, Andrew J. K. Phillips, Richa Saxena, Martin K. Rutter, Susan Redline, Heming Wang
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 12, Iss 24 (2023)
Background Excessive daytime sleepiness (EDS), experienced in 10% to 20% of the population, has been associated with cardiovascular disease and death. However, the condition is heterogeneous and is prevalent in individuals having short and long sleep
Externí odkaz:
https://doaj.org/article/afa13acef2f1495386d9a928e15d788e
Autor:
Anna Perkiö, Ilona Merikanto, Katri Kantojärvi, Tiina Paunio, Nasa Sinnott-Armstrong, Samuel E. Jones, Hanna M. Ollila
Publikováno v:
Clocks & Sleep, Vol 5, Iss 1, Pp 10-20 (2022)
Polygenic risk scores (PRSs) estimate genetic liability for diseases and traits. However, the portability of PRSs in sleep traits has remained elusive. We generated PRSs for self-reported insomnia, chronotype and sleep duration using summary data fro
Externí odkaz:
https://doaj.org/article/e6ee5f6606c546118fe3d2b03dc4ce34
Autor:
Benjamin D. Evans, Piotr Słowiński, Andrew T. Hattersley, Samuel E. Jones, Seth Sharp, Robert A. Kimmitt, Michael N. Weedon, Richard A. Oram, Krasimira Tsaneva-Atanasova, Nicholas J. Thomas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Estimating disease prevalence in biobanks is prone to error, especially for self-reported traits. Here, the authors propose a method to estimate the prevalence of a disease within a cohort based on genetic risk scores.
Externí odkaz:
https://doaj.org/article/d91ce2dcd1724d8bbce7c764767dfff3
Autor:
Shamez N Ladhani, Chris Bonell, Samuel E Jones, Meaghan Kall, Joanne Beckmann, Sinéad M Langan, Zahin Amin-Chowdhury, Felicity Aiano, Joanna Garstang, Shazaad Ahmad, Andrew J Brent, Neisha Sundaram, James Hargreaves, Georgina Ireland, Marta Bertran, Annabel Powell, Bernadette E Brent, Frances Baawuah, Ifeanychukwu Okike
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Objective To assess implementation and ease of implementation of control measures in schools as reported by staff and parents.Design A descriptive cross-sectional survey.Setting Staff and parents/guardians of the 132 primary schools and 19 secondary
Externí odkaz:
https://doaj.org/article/a1fc25c6869f4b27a0ac6a801aed6c0b
Autor:
Michael N Weedon, Samuel E Jones, Jacqueline M Lane, Jiwon Lee, Hanna M Ollila, Amy Dawes, Jess Tyrrell, Robin N Beaumont, Timo Partonen, Ilona Merikanto, Stephen S Rich, Jerome I Rotter, Timothy M Frayling, Martin K Rutter, Susan Redline, Tamar Sofer, Richa Saxena, Andrew R Wood
Publikováno v:
PLoS Genetics, Vol 18, Iss 9, p e1010356 (2022)
Rare variants in ten genes have been reported to cause Mendelian sleep conditions characterised by extreme sleep duration or timing. These include familial natural short sleep (ADRB1, DEC2/BHLHE41, GRM1 and NPSR1), advanced sleep phase (PER2, PER3, C
Externí odkaz:
https://doaj.org/article/8a07f44a6e11440e8d43f900cb9bdbf7
Autor:
Hassan S. Dashti, Iyas Daghlas, Jacqueline M. Lane, Yunru Huang, Miriam S. Udler, Heming Wang, Hanna M. Ollila, Samuel E. Jones, Jaegil Kim, Andrew R. Wood, andMe Research Team, Michael N. Weedon, Stella Aslibekyan, Marta Garaulet, Richa Saxena
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The genetic basis of daytime napping and the directional effect of daytime napping on cardiometabolic health are unknown. Here, the authors perform a genome-wide association study on self-reported daytime napping in the UK Biobank and Mendelian rando
Externí odkaz:
https://doaj.org/article/6ea11ee769b14bf6a723c6ea903c4958
Autor:
Ann-Marie K. Shorrocks, Samuel E. Jones, Kaima Tsukada, Carl A. Morrow, Zoulikha Belblidia, Johanna Shen, Iolanda Vendrell, Roman Fischer, Benedikt M. Kessler, Andrew N. Blackford
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The BLM helicase interacts with the topoisomerase TOP3A and RMI1 to form the BTR complex. Here, the authors reveal that this complex contains multiple binding sites for the single-stranded DNA-binding complex RPA, and that RPA-binding stimulates BLM
Externí odkaz:
https://doaj.org/article/b8e899d3fab949ef9615c88f13f058e9
Autor:
Michael Wainberg, Samuel E Jones, Lindsay Melhuish Beaupre, Sean L Hill, Daniel Felsky, Manuel A Rivas, Andrew S P Lim, Hanna M Ollila, Shreejoy J Tripathy
Publikováno v:
PLoS Medicine, Vol 18, Iss 10, p e1003782 (2021)
BackgroundSleep problems are both symptoms of and modifiable risk factors for many psychiatric disorders. Wrist-worn accelerometers enable objective measurement of sleep at scale. Here, we aimed to examine the association of accelerometer-derived sle
Externí odkaz:
https://doaj.org/article/056d8f88eb35459cbde00968036f70d0