Výsledky vyhledávání - "Samuel D. Waksal"

Akademický článek

Selectivity matters: selective ROCK2 inhibitor ameliorates established liver fibrosis via targeting inflammation, fibrosis, and metabolism

Autor: Alexandra Zanin-Zhorov, Wei Chen, Julien Moretti, Melanie S. Nyuydzefe, Iris Zhorov, Rashmi Munshi, Malavika Ghosh, Cindy Serdjebi, Kelli MacDonald, Bruce R. Blazar, Melissa Palmer, Samuel D. Waksal

Publikováno v: Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)

Abstract The pathogenesis of hepatic fibrosis is driven by dysregulated metabolism precipitated by chronic inflammation. Rho-associated coiled-coil-containing protein kinases (ROCKs) have been implicated in these processes, however the ability of sel

Externí odkaz: https://doaj.org/article/1360ef435b4a4bcb8e0d0bb6c03f33cd

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Akademický článek

ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells

Autor: Wei Chen, Melanie S. Nyuydzefe, Jonathan M. Weiss, Jingya Zhang, Samuel D. Waksal, Alexandra Zanin-Zhorov

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)

Abstract Rho-associated coiled-coil kinase (ROCK)2 targeting down-regulates autoimmune responses in animal models and patients, however the underlying molecular mechanism is still an enigma. We report that ROCK2 binds phosphorylated-STAT3 and its kin

Externí odkaz: https://doaj.org/article/161f3b2af832421d851906abac38085c

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Retromer Combinatorials for Gene-Therapy Across a Spectrum of Neurological Diseases

Autor: Vivek M. Patel, Gregory A. Petsko, Yasir H. Qureshi, Suvarnambiga Kannan, Samuel D. Waksal, Scott A. Small

Endosomal trafficking is a biological pathway implicated in Alzheimer’s and Parkinson’s disease, and a growing number of other neurological disorders. For this category of diseases, the endosome’s trafficking complex retromer has emerged as a v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c890f846ca8a5ec4672e2da501146663
https://doi.org/10.1101/2020.09.03.282327

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ROCK2, but not ROCK1 interacts with phosphorylated STAT3 and co-occupies TH17/TFH gene promoters in TH17-activated human T cells

Autor: Melanie S. Nyuydzefe, Alexandra Zanin-Zhorov, Wei Chen, Jingya Zhang, Samuel D. Waksal, Jonathan M. Weiss

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports

Rho-associated coiled-coil kinase (ROCK)2 targeting down-regulates autoimmune responses in animal models and patients, however the underlying molecular mechanism is still an enigma. We report that ROCK2 binds phosphorylated-STAT3 and its kinase activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de66cab8c8046b589dcb52cfafbce754
https://doaj.org/article/161f3b2af832421d851906abac38085c

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The selective ROCK2 inhibitor KD025 reduces IL-17 secretion in human peripheral blood mononuclear cells independent of IL-1 and IL-6

Autor: Melanie S. Nyuydzefe, Jonathan M. Weiss, David Kitzenberg, Jingya Zhang, Suzhao Li, Charles A. Dinarello, Wei Chen, Isak W. Tengesdal, Alexandra Zanin-Zhorov, Samuel D. Waksal

Publikováno v: European Journal of Immunology, 48, 10, pp. 1679-1686
European Journal of Immunology, 48, 1679-1686

Contains fulltext : 196332.pdf (Publisher’s version ) (Closed access) Reducing the activities of the pro-inflammatory cytokine IL-17 is an effective treatment strategy for several chronic autoimmune disorders. Rho-associated coiled-coil containing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a48407501c1c02ba6c3f824760994c
https://doi.org/10.1002/eji.201847652

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Retromer repletion with AAV9-VPS35 restores endosomal function in the mouse hippocampus

Autor: Sabrina Simoes, Diego E. Berman, Samuel D. Waksal, Rebecca Cox, Beth Stevens, Vivek M. Patel, Scott A. Small, Yasir H. Qureshi, Gregory A. Petsko, Ronald L. Klein, Suvarnambiga Kannan

Retromer has emerged as a master conductor of endosomal trafficking, and VPS35 and other retromer-related proteins are found to be deficient in late-onset Alzheimer’s disease (AD). Depleting VPS35 in neurons impairs retromer function, affecting for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb519e6c3078702a4553026108a6f28

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Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism

Publikováno v: Proceedings of the National Academy of Sciences. 111:16814-16819

Rho-associated kinase 2 (ROCK2) regulates the secretion of proinflammatory cytokines and the development of autoimmunity in mice. Data from a phase 1 clinical trial demonstrate that oral administration of KD025, a selective ROCK2 inhibitor, to health

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a36e79f6eccb8426dbdb0b76272b3ef
https://doi.org/10.1073/pnas.1414189111

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ROCK2 signaling is required to induce a subset of T follicular helper cells through opposing effects on STATs in autoimmune settings

Autor: Alissa Trzeciak, Jonathan M. Weiss, Melanie S. Nyuydzefe, James R. Tonra, Wei Chen, Samuel D. Waksal, Suzana Marusic, Bruce R. Blazar, Alexandra Zanin-Zhorov, Ryan Flynn

Publikováno v: Science signaling. 9(437)

Rho-associated kinase 2 (ROCK2) determines the balance between human T helper 17 (TH17) cells and regulatory T (Treg) cells. We investigated its role in the generation of T follicular helper (TFH) cellswhich provide help necessary to generate antibod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e8300c63de7b3a77d70c5cfcfb0de9
https://pubmed.ncbi.nlm.nih.gov/27436361

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