Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Samuel D Stimple"'
Autor:
Ruijun Zhang, Ponraj Prabakaran, Xiaocong Yu, Brian C. Mackness, Ekaterina Boudanova, Joern Hopke, Jose Sancho, Jacqueline Saleh, HyunSuk Cho, Ningning Zhang, Helene Simonds-Mannes, Samuel D. Stimple, Dietmar Hoffmann, Anna Park, Partha S. Chowdhury, Sambasiva P. Rao
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Hybridoma technology has been valuable in the development of therapeutic antibodies. More recently, antigen-specific B-cell selection and display technologies are also gaining importance. A major limitation of these approaches used for antibody disco
Externí odkaz:
https://doaj.org/article/a782d91bddb64de78fcdc7be4359ef09
Publikováno v:
Polymers, Vol 10, Iss 5, p 468 (2018)
Conventional column chromatography processes to purify recombinant proteins are associated with high production costs and slow volumetric throughput at both laboratory and large scale. Non-chromatographic purifications based on selective aggregating
Externí odkaz:
https://doaj.org/article/e4c7821c0f4e4e798f40228600e4d905
Autor:
HyunSuk Cho, Jacqueline Saleh, Sambasiva P. Rao, Partha S. Chowdhury, Joern Hopke, Samuel D. Stimple, Helene Simonds-Mannes, Jose Sancho, Xiaocong Yu, Ekaterina Boudanova, Ningning Zhang, Ruijun Zhang, Dietmar Hoffmann, Anna Park, Ponraj Prabakaran, Brian C. Mackness
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Hybridoma technology has been valuable in the development of therapeutic antibodies. More recently, antigen-specific B-cell selection and display technologies are also gaining importance. A major limitation of these approaches used for antibody disco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf16c05ecdd684234a871e8c0e99ddcd
https://doi.org/10.1080/19420862.2021.1904546
https://doi.org/10.1080/19420862.2021.1904546
Publikováno v:
AIChE J
Engineered proteins are being widely developed and employed in applications ranging from enzyme catalysts to therapeutic antibodies. Directed evolution, an iterative experimental process composed of mutagenesis and library screening, is a powerful te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca1d10721bd49d1dd7b6fbb099d5d0f
https://pubmed.ncbi.nlm.nih.gov/32719568
https://pubmed.ncbi.nlm.nih.gov/32719568
Autor:
Sibel Kalyoncu, Emily K. Makowski, Lotte T Spang, Peter M. Tessier, Wenjia Lou, Samuel D Stimple, Karen Duus, Jan Amstrup, Arne Staby, Alec A. Desai, Jesper E Mogensen, Désirée J Asgreen, Yulei Zhang
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(2)
Biologics such as peptides and proteins possess a number of attractive attributes that make them particularly valuable as therapeutics, including their high activity, high specificity, and low toxicity. However, one of the key challenges associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d7366d41b38d260c1acfe2e3d85b5d
https://pubmed.ncbi.nlm.nih.gov/33095442
https://pubmed.ncbi.nlm.nih.gov/33095442
Publikováno v:
Journal of Chemical Technology & Biotechnology. 93:1827-1835
The purification of recombinant proteins is a complicated process that requires a thorough understanding of the physical and chemical properties of each protein of interest. The unique characteristics of each protein require the development of a comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5d73281abf3b21d3ef6d1a1e0294a13
https://doi.org/10.1002/jctb.5415
https://doi.org/10.1002/jctb.5415
Publikováno v:
ACS Synthetic Biology. 6:648-658
Multitargeting small regulatory RNAs (sRNAs) represent a potentially useful tool for metabolic engineering applications. Natural multitargeting sRNAs govern bacterial gene expression by binding to the translation initiation regions of protein-coding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba26d4f14c539c27f3038c81904f2a67
https://doi.org/10.1021/acssynbio.6b00261
https://doi.org/10.1021/acssynbio.6b00261
Autor:
Lotte T Spang, Arne Staby, Peter M. Tessier, Jesper E Mogensen, Sibel Kalyoncu, Alec A. Desai, Samuel D Stimple, Désirée J Asgreen
Publikováno v:
Biotechnology and bioengineering. 116(8)
Sensitive detection of protein aggregates is important for evaluating the quality of biopharmaceuticals and detecting misfolded proteins in several neurodegenerative diseases. However, it is challenging to detect extremely low concentrations (10 ppm)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d114d5672810c43336de50b4d8ca1269
https://pubmed.ncbi.nlm.nih.gov/30982957
https://pubmed.ncbi.nlm.nih.gov/30982957
Publikováno v:
Polymers, Vol 10, Iss 5, p 468 (2018)
Polymers
Polymers; Volume 10; Issue 5; Pages: 468
Polymers
Polymers; Volume 10; Issue 5; Pages: 468
Conventional column chromatography processes to purify recombinant proteins are associated with high production costs and slow volumetric throughput at both laboratory and large scale. Non-chromatographic purifications based on selective aggregating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55594e31d8b58799a15ecff687d057e0
http://www.mdpi.com/2073-4360/10/5/468
http://www.mdpi.com/2073-4360/10/5/468
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1737
RNA biology and RNA engineering are subjects of growing interest due to recent advances in our understanding of the diverse cellular functions of RNAs, including their roles as genetic regulators. The noncoding small RNAs (sRNAs) of bacteria are a fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5ccc868e8533e524c7ea54673f08658a
https://pubmed.ncbi.nlm.nih.gov/29484604
https://pubmed.ncbi.nlm.nih.gov/29484604