Výsledky vyhledávání - "Samuel D, Wright"

Akademický článek

CSL112 (Apolipoprotein A-I [Human]) Strongly Enhances Plasma Apoa-I and Cholesterol Efflux Capacity in Post-Acute Myocardial Infarction Patients: A PK/PD Substudy of the AEGIS-I Trial

Autor: C. Michael Gibson MS, MD, Syed Hassan A. Kazmi MD, Serge Korjian MD, Gerald Chi MD, Adam T. Phillips MD, Sahar Memar Montazerin MD, Danielle Duffy MD, Bo Zheng PhD, Mark Heise PhD, Charles Liss MS, Lawrence I. Deckelbaum MD, Samuel D. Wright PhD, Andreas Gille MD, PhD

Publikováno v: Journal of Cardiovascular Pharmacology and Therapeutics, Vol 27 (2022)

Introduction: Cholesterol efflux capacity (CEC) is impaired following acute myocardial infarction (AMI). CSL112 is an intravenous preparation of human plasma-derived apoA-I formulated with phosphatidylcholine (PC). CSL112 is intended to improve CEC a

Externí odkaz: https://doaj.org/article/43aa47289dd347168bc134341711e1bc

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CSL112 Infusion Rapidly Increases APOA1 Exchange Rate via Specific Serum Amyloid-Poor HDL Subpopulations When Administered to Patients Post–Myocardial Infarction

Autor: Svetlana A. Didichenko, Elena Velkoska, Alexei V. Navdaev, Brandon H. Greene, Shuhui Wang Lorkowski, Danielle Duffy, Sojaita J. Mears, Samuel D. Wright, C. Michael Gibson, Jonathan D. Smith, Bronwyn A. Kingwell

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 43:855-869

Background: To characterize the effects of CSL112 (human APOA1 [apolipoprotein A1]) on the APOA1 exchange rate (AER) and the relationships with specific HDL (high-density lipoprotein) subpopulations when administered in the 90-day high-risk period po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2bca6243ea712487f955df545fbae747
https://doi.org/10.1161/atvbaha.122.318243

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Akademický článek

Circulating HDL levels control hypothalamic astrogliosis via apoA-I

Autor: Anna Götz, Maarit Lehti, Elizabeth Donelan, Cynthia Striese, Sebastian Cucuruz, Stephan Sachs, Chun-Xia Yi, Stephen C. Woods, Samuel D. Wright, Timo D. Müller, Matthias H. Tschöp, Yuanqing Gao, Susanna M. Hofmann

Publikováno v: Journal of Lipid Research, Vol 59, Iss 9, Pp 1649-1659 (2018)

Meta-inflammation of hypothalamic areas governing energy homeostasis has recently emerged as a process of potential pathophysiological relevance for the development of obesity and its metabolic sequelae. The current model suggests that diet-induced n

Externí odkaz: https://doaj.org/article/e48b521b49e04043b963b66df01ecbce

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Biological basis and proposed mechanism of action of CSL112 (apolipoprotein A-I [human]) for prevention of major adverse cardiovascular events in patients with myocardial infarction

Autor: Serge Korjian, Syed Hassan A Kazmi, Gerald Chi, Arzu Kalayci, Jane J Lee, Usama Talib, Samuel D Wright, Danielle Duffy, Bronwyn A Kingwell, Roxana Mehran, Paul M Ridker, C Michael Gibson

Publikováno v: European Heart Journal - Cardiovascular Pharmacotherapy.

Despite current standard of care treatment, the period shortly after acute myocardial infarction (AMI) is associated with high residual cardiovascular (CV) risk, with high rates of recurrent AMI and CV death in the first 90 days following the index e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2aa417465599ce879010f2a49942dcc7
https://doi.org/10.1093/ehjcvp/pvad014

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Pharmacometric analyses to characterize the effect of CSL112 on apolipoprotein A‐I and cholesterol efflux capacity in acute myocardial infarction patients

Autor: Helen Kastrissios, Andreas Gille, Marc Pfister, Michael A. Tortorici, Danielle Duffy, Samuel D. Wright, Pierluigi Tricoci, Bo Zheng

Publikováno v: British Journal of Clinical Pharmacology

Aims To characterize relationships between apolipoprotein A-I (apoA-I) exposure and cholesterol efflux capacity (CEC) and covariate effects following CSL112 (apoA-I [human]) administration, in an integrated population including acute myocardial infar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ce913872e7ccb5c979d78232ceaed23
https://doi.org/10.1111/bcp.14666

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ApoA-I Infusion Therapies Following Acute Coronary Syndrome: Past, Present, and Future

Autor: Arzu Kalayci, C. Michael Gibson, Paul M. Ridker, Samuel D. Wright, Bronwyn A. Kingwell, Serge Korjian, Gerald Chi, Jane J. Lee, Pierluigi Tricoci, S. Hassan Kazmi, Clara Fitzgerald, Alka Shaunik, Gail Berman, Danielle Duffy, Peter Libby

Publikováno v: Current atherosclerosis reports. 24(7)

Purpose of Review The elevated adverse cardiovascular event rate among patients with low high-density lipoprotein cholesterol (HDL-C) formed the basis for the hypothesis that elevating HDL-C would reduce those events. Attempts to raise endogenous HDL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d6c8b404259beec7b365cd1f2e2f03b
https://pubmed.ncbi.nlm.nih.gov/35524914

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Nascent HDL (High-Density Lipoprotein) Discs Carry Cholesterol to HDL Spheres

Autor: Alexei V Navdaev, Lorenzo Sborgi, Samuel D. Wright, Svetlana A Didichenko

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 40:1182-1194

Objective: To characterize the fate of protein and lipid in nascent HDL (high-density lipoprotein) in plasma and explore the role of interaction between nascent HDL and mature HDL in promoting ABCA1 (ATP-binding cassette transporter 1)-dependent chol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::53918bb3760bed98f87c3563bad45a75
https://doi.org/10.1161/atvbaha.120.313906

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Akademický článek

Phenolic acids suppress adipocyte lipolysis via activation of the nicotinic acid receptor GPR109A (HM74a/PUMA-G)

Autor: Ning Ren, Rebecca Kaplan, Melba Hernandez, Kang Cheng, Lan Jin, Andrew K.P. Taggart, Amber Y. Zhu, Xiaodong Gan, Samuel D. Wright, Tian-Quan Cai

Publikováno v: Journal of Lipid Research, Vol 50, Iss 5, Pp 908-914 (2009)

Phenolic acids are found in abundance throughout the plant kingdom. Consumption of wine or other rich sources of phenolic acids, such as the “Mediterranean diet,” has been associated with a lower risk of cardiovascular disease. The underlying mec

Externí odkaz: https://doaj.org/article/545d68b5660a45b4bb4183b00c46f3ef

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Akademický článek

Functional analysis of sites within PCSK9 responsible for hypercholesterolemias⃞

Autor: Shilpa Pandit, Doug Wisniewski, Joseph C. Santoro, Sookhee Ha, Vijayalakshmi Ramakrishnan, Rose M. Cubbon, Richard T. Cummings, Samuel D. Wright, Carl P. Sparrow, Ayesha Sitlani, Timothy S. Fisher

Publikováno v: Journal of Lipid Research, Vol 49, Iss 6, Pp 1333-1343 (2008)

Mutations within proprotein convertase subtilisin/kexin type 9 (PCSK9) are associated with dominant forms of familial hypercholesterolemia. PCSK9 binds the LDL receptor (LDLR), and addition of PCSK9 to cells promotes degradation of LDLR. PCSK9 mutant

Externí odkaz: https://doaj.org/article/596c24147eaa41d09b15a93821963feb

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Abstract 10220: CSL112 (Apolipoprotein A-I (human)) Infusion Rapidly Increases ApoA-I Exchange Rate via Specific Serum Amyloid-Poor HDL Sub-Populations When Administered to Patients Post Myocardial Infarction

Autor: Svetlana A Didichenko, Elena Velkoska, Alexey V Navdaev, Brandon H Greene, Shuhui W Lorkowski, Jenny J Mears, Samuel D Wright, C M Gibson, Jonathan D Smith, Bronwyn A Kingwell

Publikováno v: Circulation. 144

Background: Apolipoprotein A-I (apoA-I) exchange rate (AER) into plasma high density lipoprotein (HDL) may represent a cell-free measure of HDL function, and predict recurrent major adverse cardiovascular events post-acute myocardial infarction (AMI)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44e3415e2889c8db70a7c1411a4bbfc2
https://doi.org/10.1161/circ.144.suppl_1.10220

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