Zobrazeno 1 - 10
of 162
pro vyhledávání: '"Samuel C. Silverstein"'
Autor:
Taha Merghoub, Jedd D. Wolchok, Yongbiao Li, Ricardo Toledo-Crow, Samuel C. Silverstein, Xia Yang, David Schaer, Katherine S. Panageas, Sadna Budhu, Hong Zhong, Alan N. Houghton
Publikováno v:
Science Signaling. 10
Regulatory T cells (T regs ) suppress antitumor immunity by inhibiting the killing of tumor cells by antigen-specific CD8 + T cells. To better understand the mechanisms involved, we used ex vivo three-dimensional collagen-fibrin gel cultures of disso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc48ed9d33515a4fb5e4ae6a5a926622
https://doi.org/10.1126/scisignal.aak9702
https://doi.org/10.1126/scisignal.aak9702
Autor:
Monty Krieger, Geoffrey M. Thiele, Joseph El Khoury, John D. Loike, Mercy PrabhuDas, Xiang-Yang Wang, Paul L. Bollyky, Maria Febbraio, Cynthia L. Baldwin, Samuel D. Wright, Dawn M. E. Bowdish, Terry K. Means, Tatsuya Sawamura, Robert C. Speth, Janice C. Telfer, Samuel C. Silverstein, Kurt Drickamer, Søren K. Moestrup, Lester Kobzik, Steven R. Post, Benita L. McVicker, Joachim Herz
Publikováno v:
PMC
PrabhuDas, M R, Baldwin, C L, Bollyky, P L, Bowdish, D M E, Drickamer, K, Febbraio, M, Herz, J, Kobzik, L, Krieger, M, Loike, J, McVicker, B, Means, T K, Moestrup, S K, Post, S R, Sawamura, T, Silverstein, S, Speth, R C, Telfer, J C, Thiele, G M, Wang, X-Y, Wright, S D & El Khoury, J 2017, ' A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease ', Journal of Immunology, vol. 198, no. 10, pp. 3775-3789 . https://doi.org/10.4049/jimmunol.1700373
The Journal of Immunology
PrabhuDas, M R, Baldwin, C L, Bollyky, P L, Bowdish, D M E, Drickamer, K, Febbraio, M, Herz, J, Kobzik, L, Krieger, M, Loike, J, McVicker, B, Means, T K, Moestrup, S K, Post, S R, Sawamura, T, Silverstein, S, Speth, R C, Telfer, J C, Thiele, G M, Wang, X-Y, Wright, S D & El Khoury, J 2017, ' A Consensus Definitive Classification of Scavenger Receptors and Their Roles in Health and Disease ', Journal of Immunology, vol. 198, no. 10, pp. 3775-3789 . https://doi.org/10.4049/jimmunol.1700373
The Journal of Immunology
Scavenger receptors constitute a large family of proteins that are structurally diverse and participate in a wide range of biological functions. These receptors are expressed predominantly by myeloid cells and recognize a diverse variety of ligands i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff8bf2f404e17ee3d5c4bae09101db2f
https://orcid.org/0000-0003-4541-5181
https://orcid.org/0000-0003-4541-5181
Autor:
Samuel C. Silverstein, Raul Rabadan
Publikováno v:
Journal of Clinical Investigation. 122:2776-2779
Many chemotherapeutic regimens produce neutropenia, which predisposes to microbial infection. However, not all neutropenic individuals develop infections, so the ability to predict this outcome would be a powerful clinical tool. In this issue of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::818acca9e8b934f2f95a5827590978f6
https://doi.org/10.1172/jci63939
https://doi.org/10.1172/jci63939
Autor:
David J. Pinsky, Anatoly A. Starkov, Samuel C. Silverstein, Baalasubramanian Sivasankar, Veniamin Ratner, Raymond I. Stark, Deborah A. Fraser, Vadim S. Ten, Jun Yao, B. Paul Morgan, Richard A. Polin, Sergey A. Sosunov, Marina Botto, Susan J. Vannucci
Publikováno v:
The Journal of Neuroscience. 30:2077-2087
Hypoxic–ischemic (HI) brain injury in infants is a leading cause of lifelong disability. We report a novel pathway mediating oxidative brain injury after hypoxia–ischemia in which C1q plays a central role. Neonatal mice incapable of classical or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67bcd2f1fb3af0c99a226b5c724aa118
https://doi.org/10.1523/jneurosci.5249-09.2010
https://doi.org/10.1523/jneurosci.5249-09.2010
Autor:
Andrei Constantinescu, Geoffrey Catalano, Ashley Pandolfi, Raphael Clynes, John D. Loike, Soo Han, Samuel C. Silverstein, Sadna Budhu
Publikováno v:
The Journal of Experimental Medicine
We describe a quantitative model for assessing the cytolytic activity of antigen-specific CD8+ T cells in vitro and in vivo in which the concentration of antigen-specific CD8+ T cells determines the efficiency with which these cells kill cognate anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe68f6d37c9e9906b1c2cbec19e74e0
http://europepmc.org/articles/PMC2812553
http://europepmc.org/articles/PMC2812553
Publikováno v:
Journal of Leukocyte Biology. 78:1166-1174
Adhesion of mononuclear phagocytes (Macs) to extracellular matrices containing oxidized low-density lipoproteins (oxLDL) stimulates these cells to secrete reactive oxygen species (e.g., O2–, H2O2) that are believed to promote atherogenesis. Current
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c79cf8d986add7f7d4b1954d58d40f
https://doi.org/10.1189/jlb.0205101
https://doi.org/10.1189/jlb.0205101
Autor:
John D. Loike, Emily Lu, Samuel C. Silverstein, Ira J. Goldberg, R. Neuhut, Jens Husemann, S. Malitzky, D. Y. Shabtai
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 24:2051-2056
Objectives— An inflammatory response to altered lipoproteins that accumulate in the arterial wall is a major component of the pathogenesis of atherosclerosis. Statins reduce plasma levels of low-density lipoprotein (LDL) and are effective treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6027f98e3e31e3a272068c5eaf2711f
https://doi.org/10.1161/01.atv.0000143858.15909.29
https://doi.org/10.1161/01.atv.0000143858.15909.29
Autor:
Fengrong Yan, Samuel C. Silverstein, Roman Anankov, Thomas C. Brionne, Emily Lu, Tony Wyss-Coray, Jens Husemann, John D. Loike
Publikováno v:
Nature Medicine. 9:453-457
Alzheimer disease (AD) is a progressive neurodegenerative disorder characterized by excessive deposition of amyloid-beta (Abeta) peptides in the brain. One of the earliest neuropathological changes in AD is the accumulation of astrocytes at sites of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36333e73974d045106f4a8fda3362be6
https://doi.org/10.1038/nm838
https://doi.org/10.1038/nm838
Publikováno v:
Glia. 40:195-205
Scavenger receptor class A (SR-A, CD204), scavenger receptor-BI (SR-BI), and CD36 are cell surface proteins that mediate cell adhesion to, and endocytosis of, various native and pathologically modified substances, and participate in intracellular sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8755747ec1888f5ce69a06d7743b4c7f
https://doi.org/10.1002/glia.10148
https://doi.org/10.1002/glia.10148
Publikováno v:
Proceedings of the National Academy of Sciences. 99:8289-8294
We have examined the effect of neutrophil concentration on killing of a clinical isolate ofStaphylococcusepidermidis. Human neutrophils at concentrations varying from 105to 107per ml were mixed in suspension withS. epidermidisat concentrations varyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51737461c59218fb3cd5025c65909f4c
https://doi.org/10.1073/pnas.122244799
https://doi.org/10.1073/pnas.122244799