Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Samuel C. Griffiths"'
Autor:
Tomas Malinauskas, Gareth Moore, Amalie F. Rudolf, Holly Eggington, Hayley L. Belnoue-Davis, Kamel El Omari, Samuel C. Griffiths, Rachel E. Woolley, Ramona Duman, Armin Wagner, Simon J. Leedham, Clair Baldock, Hilary L. Ashe, Christian Siebold
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Twisted gastrulation (TWSG1) is an evolutionarily conserved secreted glycoprotein which controls signaling by Bone Morphogenetic Proteins (BMPs). TWSG1 binds BMPs and their antagonist Chordin to control BMP signaling during embryonic develop
Externí odkaz:
https://doaj.org/article/ddfaa798787944ee8ae8169dabd72ec6
Autor:
Samuel C. Griffiths, Rebekka A. Schwab, Kamel El Omari, Benjamin Bishop, Ellen J. Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F. Covey, Robert J. C. Gilbert, Rajat Rohatgi, Christian Siebold
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Hedgehog-Interacting Protein (HHIP) is the only reported secreted inhibitor of Sonic Hedgehog (SHH) signalling. Here, the authors report structures of the HHIP N- and C-terminal domains, both in complexes with glycosaminoglycans, providing insights i
Externí odkaz:
https://doaj.org/article/420c08df587c4e738a4706dedda2d860
Autor:
Rong Li, Ningyan Zhang, Zhiqiang An, Wei Xiong, Huai-Chin Chiang, Hui Deng, Junquan Liu, Victor Laurent, Samuel C Griffiths, Jasmin Dülfer, Xiujie Sun, Y Whitney Yin, Wenliang Li, Laurent P Audoly, Thomas Schürpf
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 6 (2023)
Background Immune exclusion (IE) where tumors deter the infiltration of immune cells into the tumor microenvironment has emerged as a key mechanism underlying immunotherapy resistance. We recently reported a novel role of discoidin domain-containing
Externí odkaz:
https://doaj.org/article/3537ca4000574c579032deb0a579a11b
Autor:
Laura C. Clark, Kate E. Atkin, Fiona Whelan, Andrew S. Brentnall, Gemma Harris, Aisling M. Towell, Johan P. Turkenburg, Yan Liu, Ten Feizi, Samuel C. Griffiths, Joan A. Geoghegan, Jennifer R. Potts
Staphylococcus aureus and Staphylococcus epidermidis are frequently associated with medical device infections that involve establishment of a bacterial biofilm on the device surface. Staphylococcal surface proteins Aap, SasG, and Pls are members of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2eb7e8c4a424c63c4bb0e916418d50
http://hdl.handle.net/10044/1/102804
http://hdl.handle.net/10044/1/102804
Autor:
Fiona, Whelan, Huw T, Jenkins, Samuel C, Griffiths, Robert T, Byrne, Eleanor J, Dodson, Alfred A, Antson
Publikováno v:
Acta Crystallographica Section D: Biological Crystallography
The crystal structure of a human dihydrouridine synthase, an enzyme associated with lung cancer, with 18% sequence identity to a T. maritima enzyme, has been determined at 1.9 Å resolution by molecular replacement after extensive molecular remodelli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89be6031c678a01fb97efba0ef56796a
https://pubmed.ncbi.nlm.nih.gov/26143927
https://pubmed.ncbi.nlm.nih.gov/26143927
Autor:
Samuel C Griffiths, Jia Tan, Armin Wagner, Levi L Blazer, Jarrett J Adams, Srisathya Srinivasan, Shayan Moghisaei, Sachdev S Sidhu, Christian Siebold, Hsin-Yi Henry Ho
Publikováno v:
eLife, Vol 13 (2024)
The receptor tyrosine kinase ROR2 mediates noncanonical WNT5A signaling to orchestrate tissue morphogenetic processes, and dysfunction of the pathway causes Robinow syndrome, brachydactyly B, and metastatic diseases. The domain(s) and mechanisms requ
Externí odkaz:
https://doaj.org/article/439dab7e296646b59ddc2e91b98ed24d