Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Samuel C. Flores"'
Autor:
Thomas R Caulfield, Fabienne C Fiesel, Elisabeth L Moussaud-Lamodière, Daniel F A R Dourado, Samuel C Flores, Wolfdieter Springer
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 11, p e1003935 (2014)
Loss-of-function mutations in PINK1 or PARKIN are the most common causes of autosomal recessive Parkinson's disease. Both gene products, the Ser/Thr kinase PINK1 and the E3 Ubiquitin ligase Parkin, functionally cooperate in a mitochondrial quality co
Externí odkaz:
https://doaj.org/article/f7354ae969fb4bd9aa4f52cf1971f172
Autor:
Anders Virtanen, U. Helena Danielson, Mohammad Reza Housaindokht, Olle Nordesjö, Sara Marie Øie Solbak, Daniel F. A. R. Dourado, Ken G. Andersson, Mikael Nissbeck, John Löfblom, Samuel C. Flores, Masoumeh Nosrati
Publikováno v:
Protein Engineering, Design and Selection. 30:593-601
The interaction between the Staphylococcal Protein A (SpA) domain B (the basis of the Affibody) molecule and the Fc of IgG is key to the use of Affibodies in affinity chromatography and in potential therapies against certain inflammatory diseases. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c5aca5ad42c498a4412956f0022a50
https://doi.org/10.1093/protein/gzx023
https://doi.org/10.1093/protein/gzx023
Autor:
Faruck Morcos, Olle Nordesjö, Samuel C. Flores, Ryan R. Cheng, Ryan L. Hayes, José N. Onuchic, Herbert Levine
Publikováno v:
Molecular Biology and Evolution
Two-component signaling (TCS) is the primary means by which bacteria sense and respond to the environment. TCS involves two partner proteins working in tandem, which interact to perform cellular functions while limiting interactions with non-partners
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff7dcfd69c54025095bc0574636412f
https://doi.org/10.1093/molbev/msw188
https://doi.org/10.1093/molbev/msw188
Publikováno v:
Nucleic Acids Research
Easy-to-use macromolecular viewers, such as UCSF Chimera, are a standard tool in structural biology. They allow rendering and performing geometric operations on large complexes, such as viruses and ribosomes. Dynamical simulation codes enable modelin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7a43712676ea548a1f79ae5791c147a
https://doi.org/10.1093/nar/gkv1457
https://doi.org/10.1093/nar/gkv1457
Autor:
Thomas R. Caulfield, Kotaro Ogaki, Samuel C. Flores, Daniel F. A. R. Dourado, Owen A. Ross, Elisabeth L. Moussaud-Lamodière, Wolfdieter Springer, Fabienne C. Fiesel
Publikováno v:
Human Mutation. 36:774-786
Mutations in the PARKIN/PARK2 gene that result in loss-of-function of the encoded, neuroprotective E3 ubiquitin ligase Parkin cause recessive, familial early-onset Parkinson disease. As an increasing number of rare Parkin sequence variants with uncle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d720a9216b73f626cafff042615b227
https://doi.org/10.1002/humu.22808
https://doi.org/10.1002/humu.22808
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 82:2681-2690
Substitution mutations in protein-protein interfaces can have a substantial effect on binding, which has consequences in basic and applied biomedical research. Experimental expression, purification, and affinity determination of protein complexes is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48e3f105909f5881dac24868f0410196
https://doi.org/10.1002/prot.24634
https://doi.org/10.1002/prot.24634
Autor:
Howook Hwang, Shiyong Liu, Xiaoqin Zou, Huan-Xiang Zhou, Hideaki Umeyama, Paul A. Bates, Hahnbeom Park, Yangyu Huang, Xiaolei Zhu, Marianne Rooman, Rudi Agius, David Baker, Sarel J. Fleishman, Dimitri Gillis, Eiji Kanamori, Yuko Tsuchiya, Sandor Vajda, Panagiotis L. Kastritis, Brian Jimenez, Thom Vreven, Xiufeng Yang, Hiromitsu Shimoyama, Nan Zhao, Zhiping Weng, Sheng-You Huang, Mikael Trellet, Chaok Seok, Samuel C. Flores, Miguel Romero-Durana, Sanbo Qin, Michael S. Pacella, Julie C. Mitchell, Mayuko Takeda-Shitaka, Dmitri Beglov, Jeffrey J. Gray, Shoshana J. Wodak, Rocco Moretti, Martin Zacharias, Dmitry Korkin, Dima Kozakov, João P. G. L. M. Rodrigues, Haruki Nakamura, Juan Esquivel-Rodríguez, Mieczyslaw Torchala, Yves Dehouck, Alexandre M. J. J. Bonvin, David R. Hall, Mitsuo Iwadate, Krishna Praneeth Kilambi, Jamica Sarmiento, Daron M. Standley, Joël Janin, Omar N. A. Demerdash, Brian G. Pierce, Chiara Pallara, Meng Cui, Shusuke Teraguchi, Petr Popov, Hasup Lee, Haotian Li, Juan Fernández-Recio, Laura Pérez-Cano, Sergei Grudinin, Sameer Velankar, Daisuke Kihara, Xiaofeng Ji, Genki Terashi, Yi Xiao, Shide Liang, Iain H. Moal
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 81:1980-1987
Community-wide blind prediction experiments such as CAPRI and CASP provide an objective measure of the current state of predictive methodology. Here we describe a community-wide assessment of methods to predict the effects of mutations on protein-pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c35f351f56e60c23e4c4383987063979
https://doi.org/10.1002/prot.24356
https://doi.org/10.1002/prot.24356
Publikováno v:
Scientific Reports
It is possible to accurately and economically predict change in protein-protein interaction energy upon mutation (ΔΔG), when a high-resolution structure of the complex is available. This is of growing usefulness for design of high-affinity or other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98cc56ff843ef978edd52037cc08d985
https://pubmed.ncbi.nlm.nih.gov/27173910
https://pubmed.ncbi.nlm.nih.gov/27173910
Autor:
Katarzyna Mikolajczak, Alexander Serganov, Christina Waldsich, Song Cao, Anna Philips, Samuel C. Flores, Rhiju Das, Magdalena Rother, Dinshaw J. Patel, Christopher A. Lavender, Tomasz Puton, Fredrick Sijenyi, Irina Tuszynska, Michal J. Boniecki, John SantaLucia, Kevin M. Weeks, Marcin Skorupski, José Almeida Cruz, Lili Huang, Parin Sripakdeevong, Marc Frédérick Blanchet, Janusz M. Bujnicki, Shi-Jie Chen, Thomas Hermann, François Major, Nikolay V. Dokholyan, Tomasz Sołtysiński, Kristian Rother, Eric Westhof, Michael Wildauer, Neocles B. Leontis, Feng Ding, Véronique Lisi
Publikováno v:
RNA. 18:610-625
We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles. The goals are to assess the leading edge of RNA structure prediction techniques; compare existin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd4efb7aa9ecba8d38c9bc26d7f039c
https://doi.org/10.1261/rna.031054.111
https://doi.org/10.1261/rna.031054.111
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 8:1247-1257
Modeling the structure and dynamics of large macromolecules remains a critical challenge. Molecular dynamics (MD) simulations are expensive because they model every atom independently, and are difficult to combine with experimentally derived knowledg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f7be2518eb5e4e32ce1a8795d56657
https://doi.org/10.1109/tcbb.2010.104
https://doi.org/10.1109/tcbb.2010.104