Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Samuel C. Brooks"'
Publikováno v:
Carcinogenesis. 27:848-855
Biomarkers of exposure & effect:: validationBiomarker: A-T carriersExposure/effect represented: DMBAStudy type (in vitro, animals, humans): Atm male miceMode of exposure (if in vivo) (acute, chronic, root of exposure): administration by oral gavageMe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4599b13a6ed8cd7a675219f90a71862f
https://doi.org/10.1093/carcin/bgi302
https://doi.org/10.1093/carcin/bgi302
Publikováno v:
Journal of Medicinal Chemistry. 40:3659-3669
Analogues of estradiol-17 beta (E2) have been evaluated for estrogen receptor (ER) binding affinity and mitogenic potential in the human breast cancer cell line MCF-7. These 42 compounds represent subtle modifications of the natural estrogen structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b811ac2a90943fb64aeffdc28be78ea8
https://doi.org/10.1021/jm9703294
https://doi.org/10.1021/jm9703294
Publikováno v:
Breast Cancer Research and Treatment. 37:253-266
There has been increasing evidence which suggests that abnormal expression of the estrogen receptor (ER) protein in nonmalignant breast tissue may be important in the carcinogenic process. To examine the effects of ER expression in immortalized nonma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f618bfec2fa01a778812e31ca0dd7d
https://doi.org/10.1007/bf01806507
https://doi.org/10.1007/bf01806507
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 54:201-210
The effect of estrogen structure on the conformation of the complex formed with estrogen receptor (ER) and the consensus estrogen response element (EREc) has been examined with gel mobility shift assay. Proteins in MCF-7 cell extracts formed three di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ce9e24fc7ae9f024e0f572b8b91515
https://doi.org/10.1016/0960-0760(95)00137-o
https://doi.org/10.1016/0960-0760(95)00137-o
Publikováno v:
Biochemistry. 32:7016-7021
These experiments were designed to examine the effect of structural modifications to the estradiol-17 beta (E2) molecule on the estrogen response element (ERE) dependent activation of the thymidine kinase (tk) promoter. Estrogen receptor (ER) positiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9c1f3f0ecaffa36d6ba8c8d2588459f
https://doi.org/10.1021/bi00078a029
https://doi.org/10.1021/bi00078a029
Publikováno v:
Biochemistry. 32:7009-7015
The influence of structural alterations to the estradiol-17 beta (E2) molecule on the induction of pS2 and Cathepsin D (Cath D) mRNAs has been examined by Northern analysis of RNA extracted from MCF-7 cells. Exposure of cultures to estratriene did no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2704b3392d8c45c7ab093cfcdea43099
https://doi.org/10.1021/bi00078a028
https://doi.org/10.1021/bi00078a028
Publikováno v:
Journal of cellular biochemistry. 99(5)
Centrosome amplification has been proposed to contribute to the development of aneuploidy and genome instability. Here, we show that Ataxia-Telangiectasia Mutated (ATM) is localized to the centrosome and co-purified with gamma-tubulin. The importance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b2b3d7067ec34bf19e0eb623bceb11
https://pubmed.ncbi.nlm.nih.gov/16775842
https://pubmed.ncbi.nlm.nih.gov/16775842
Publikováno v:
Molecular carcinogenesis. 44(4)
Acute promyelocytic leukemia (APL) is invariably associated with chromosomal translocation to retinoic acid receptor alpha (RARalpha) locus. In a vast majority of cases, RARalpha translocates to and fuses with the promyelocytic leukemia (PML) gene. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bbe55b45e57fe46ed38e8577f45db89
https://pubmed.ncbi.nlm.nih.gov/16273555
https://pubmed.ncbi.nlm.nih.gov/16273555
Publikováno v:
Developmental dynamics : an official publication of the American Association of Anatomists. 234(4)
Retinoic acid (RA), a bioactive chemical compound synthesized from dietary derived vitamin A, has been successfully used as a chemopreventive and chemotherapeutic agent through the regulation of cell proliferation, differentiation, and apoptosis acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1e4d521306a6b64dfb423ec8ca0e36c
https://pubmed.ncbi.nlm.nih.gov/16217742
https://pubmed.ncbi.nlm.nih.gov/16217742
Autor:
Chu-Xia Deng, Samuel C. Brooks, Shu Lu, Y. Alan Wang, Henry H.Q. Heng, Kate C. Shen, Yaolin Wang, Guo Liu
Publikováno v:
Cancer research. 65(19)
The DNA damage checkpoint protein kinase mutated in ataxia telangiectasia (ATM) is involved in sensing and transducing DNA damage signals by phosphorylating and activating downstream target proteins that are implicated in the regulation of cell cycle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c386ced6428533deeed733ae8b4901f6
https://pubmed.ncbi.nlm.nih.gov/16204044
https://pubmed.ncbi.nlm.nih.gov/16204044