Fractional killing arises from cell‐to‐cell variability in overcoming a caspase activity threshold

Autor: Jérémie Roux, Marc Hafner, Samuel Bandara, Joshua J Sims, Hannah Hudson, Diana Chai, Peter K Sorger

Publikováno v: Molecular Systems Biology, Vol 11, Iss 5, Pp 1-17 (2015)

Abstract When cells are exposed to death ligands such as TRAIL, a fraction undergoes apoptosis and a fraction survives; if surviving cells are re‐exposed to TRAIL, fractional killing is once again observed. Therapeutic antibodies directed against T

Externí odkaz: https://doaj.org/article/6e360956b93c4ce48e060381bc9b5364

Optimal experimental design for parameter estimation of a cell signaling model.

Autor: Samuel Bandara, Johannes P Schlöder, Roland Eils, Hans Georg Bock, Tobias Meyer

Publikováno v: PLoS Computational Biology, Vol 5, Iss 11, p e1000558 (2009)

Differential equation models that describe the dynamic changes of biochemical signaling states are important tools to understand cellular behavior. An essential task in building such representations is to infer the affinities, rate constants, and oth

Externí odkaz: https://doaj.org/article/c8c03d17b59843e7a3d0d5356f45e82b

A Mathematical Model for the Transport of Paclitaxel (Taxol) Across the Blood-Brain Barrier

Autor: Gert Fricker, Samuel Bandara, Moritz Diehl

Publikováno v: Chemical Engineering Research and Design. 85:1065-1071

Paclitaxel (Taxol) from Taxus brevifolia is an antimitotic drug that is successfully used in the fight against many different types of cancers. However, exclusion of paclitaxel from the central nervous system by the blood-brain barrier is a major obs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c6ec3a0ee28688aa35eff1902609a37
https://doi.org/10.1205/cherd06238

Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons

Autor: Sean R. Collins, Tobias Meyer, Feng-Chiao Tsai, Maja Matis, Milos Galic, Samuel Bandara

Publikováno v: Galic, M; Tsai, F-C; Collins, SR; Matis, M; Bandara, S; & Meyer, T. (2014). Dynamic recruitment of the curvature-sensitive protein ArhGAP44 to nanoscale membrane deformations limits exploratory filopodia initiation in neurons. ELIFE, 3, e03116. doi: 10.7554/eLife.03116. UC Davis: Retrieved from: http://www.escholarship.org/uc/item/94d5c6jc
eLife, Vol 3 (2014)
eLife

In the vertebrate central nervous system, exploratory filopodia transiently form on dendritic branches to sample the neuronal environment and initiate new trans-neuronal contacts. While much is known about the molecules that control filopodia extensi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4702dcb07bb9be67a65ca4a09f91be40
http://www.escholarship.org/uc/item/94d5c6jc

Regulators of Calcium Homeostasis Identified by Inference of Kinetic Model Parameters from Live Single Cells Perturbed by siRNA

Autor: Tobias Meyer, Samuel Bandara, Seth Malmersjö

Publikováno v: Science Signaling. 6

Assigning molecular functions and revealing dynamic connections between large numbers of partially characterized proteins in regulatory networks are challenges in systems biology. We showed that functions of signaling proteins can be discovered with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658ac987e26c880d8a66ecf2dad8feba
https://doi.org/10.1126/scisignal.2003649