Výsledky vyhledávání - "Samuel B. Sereda"

Akademický článek

Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance

Autor: Michael Shum, Mayuko Segawa, Raffi Gharakhanian, Ana Viñuela, Matthew Wortham, Siyouneh Baghdasarian, Dane M. Wolf, Samuel B. Sereda, Laura Nocito, Linsey Stiles, Zhiqiang Zhou, Vincent Gutierrez, Maike Sander, Orian S. Shirihai, Marc Liesa

Publikováno v: Molecular Metabolism, Vol 55, Iss , Pp 101403- (2022)

Objective: The contribution of beta-cell dysfunction to type 2 diabetes (T2D) is not restricted to insulinopenia in the late stages of the disease. Elevated fasting insulinemia in normoglycemic humans is a major factor predicting the onset of insulin

Externí odkaz: https://doaj.org/article/9dc2c70f85334be6a42fd766bfb0b160

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Deletion of ABCB10 in beta-cells protects from high-fat diet induced insulin resistance

Autor: Linsey Stiles, Maike Sander, Samuel B. Sereda, Zhiqiang Zhou, Ana Viñuela, Siyouneh Baghdasarian, Vincent Gutierrez, Mayuko Segawa, Laura Nocito, Matthew Wortham, Raffi Gharakhanian, Marc Liesa, Michael Shum, Orian S. Shirihai, Dane M. Wolf

Publikováno v: Molecular Metabolism, Vol 55, Iss, Pp 101403-(2022)
Molecular Metabolism

Objective The contribution of beta-cell dysfunction to type 2 diabetes (T2D) is not restricted to insulinopenia in the late stages of the disease. Elevated fasting insulinemia in normoglycemic humans is a major factor predicting the onset of insulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39ab74e8712b67cebb98c697cad3452
http://www.sciencedirect.com/science/article/pii/S2212877821002611

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Individual islet respirometry reveals functional diversity within the islet population of mice and human donors

Autor: Samuel B. Sereda, Orian S. Shirihai, Patrick McDonald, Melena D. Bellin, Eleni Ritou, Marc Liesa, Linsey Stiles, J. J. Wilhelm, Muhamad Abdullah, Andrew Neilson, Kacey Caradonna, Zachary Swanson, Evan P. Taddeo, Dane M. Wolf

Publikováno v: Molecular Metabolism, Vol 16, Iss, Pp 150-159 (2018)

Objective: Islets from the same pancreas show remarkable variability in glucose sensitivity. While mitochondrial respiration is essential for glucose-stimulated insulin secretion, little is known regarding heterogeneity in mitochondrial function at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c76e3b7722a70cf409f39222149d5e2
http://www.sciencedirect.com/science/article/pii/S2212877818304861

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Mitochondrial Proton Leak Regulated by Cyclophilin D Elevates Insulin Secretion in Islets at Nonstimulatory Glucose Levels

Autor: Joshua J. Wilhelm, Jakob D. Wikstrom, Eleni Ritou, Melena D. Bellin, Orian S. Shirihai, Richard G. Kibbey, Zachary Swanson, Linsey Stiles, Siyouneh Baghdasarian, Karel A. Erion, Nour Alsabeeh, Jin Li, Samuel B. Sereda, Marc Liesa, Evan P. Taddeo, Muhamad Abdulla

Publikováno v: Diabetes

Fasting hyperinsulinemia precedes the development of type 2 diabetes. However, it is unclear whether fasting insulin hypersecretion is a primary driver of insulin resistance or a consequence of the progressive increase in fasting glycemia induced by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::581d4a20e4236c1068611cfeedd4774f
https://pubmed.ncbi.nlm.nih.gov/31740442

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β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

Autor: Samuel B. Sereda, Christine A. Robson-Doucette, Alpana Bhattacharjee, Sobia Sultan, Kacey J. Prentice, Emma M. Allister, Orian S. Shirihai, Michael B. Wheeler, Jakob D. Wikstrom, Vasilij Koshkin

Publikováno v: Diabetes

OBJECTIVE The role of uncoupling protein 2 (UCP2) in pancreatic β-cells is highly debated, partly because of the broad tissue distribution of UCP2 and thus limitations of whole-body UCP2 knockout mouse models. To investigate the function of UCP2 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42fa482eba95c3f34ce0906847b91ba2
https://doi.org/10.2337/db11-0132

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A Novel High-Throughput Assay for Islet Respiration Reveals Uncoupling of Rodent and Human Islets

Autor: Linsey Stiles, Alvaro A. Elorza, David A. Ferrick, Emma M. Allister, Orian S. Shirihai, Samuel B. Sereda, Andy Neilson, Michael B. Wheeler, Jakob D. Wikstrom

Publikováno v: PLoS ONE
PLoS ONE, Vol 8, Iss 12 (2013)

Due to errors introduced during the production process, Figure 1 and Figure 2 are incomplete. The full, correct figures can be found here: Figure 1: http://plosone.org/corrections/pone.0033023.g001.cn.tif Figure 2: http://plosone.org/corrections/pone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93bda04d2f61126220ee863b4f631dd
http://europepmc.org/articles/PMC3855804

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A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets

Autor: Andy Neilson, Linsey Stiles, Emma M. Allister, Orian S. Shirihai, Alvaro A. Elorza, Jakob D. Wikstrom, Michael B. Wheeler, Samuel B. Sereda, David A. Ferrick

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e33023 (2012)
PLoS ONE

Background The pancreatic beta cell is unique in its response to nutrient by increased fuel oxidation. Recent studies have demonstrated that oxygen consumption rate (OCR) may be a valuable predictor of islet quality and long term nutrient responsiven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb761d092dcd25bf4b8162b6f25c3e4
http://europepmc.org/articles/PMC3351473?pdf=render

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Akademický článek

A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets.

Autor: Jakob D Wikstrom, Samuel B Sereda, Linsey Stiles, Alvaro Elorza, Emma M Allister, Andy Neilson, David A Ferrick, Michael B Wheeler, Orian S Shirihai

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e33023 (2012)

The pancreatic beta cell is unique in its response to nutrient by increased fuel oxidation. Recent studies have demonstrated that oxygen consumption rate (OCR) may be a valuable predictor of islet quality and long term nutrient responsiveness. To dat

Externí odkaz: https://doaj.org/article/113026f2fefc41b1898270645fef0a88

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