Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Samuel Acreman"'
Autor:
Samuel Acreman, Jinfang Ma, Geoffrey Denwood, Rui Gao, Andrei Tarasov, Patrik Rorsman, Quan Zhang
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109665- (2024)
Summary: Glucagon is secreted by pancreatic α-cells to counteract hypoglycaemia. How glucose regulates glucagon secretion remains unclear. Here, using mouse islets, we studied the role of transmembrane and endoplasmic reticulum (ER) Ca2+ on intrinsi
Externí odkaz:
https://doaj.org/article/9d8228070ca146558708556c8a9d5657
Publikováno v:
Bioengineering, Vol 11, Iss 8, p 828 (2024)
Throughout the isolation process, human islets are subjected to destruction of the islet basement membrane (BM) and reduced oxygen supply. Reconstruction of the BM represents an option to improve islet function and survival post-transplant and may pa
Externí odkaz:
https://doaj.org/article/579c418e49024012a00e0dc443ce15ce
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The impact of ischaemia can severely damage procured donor organs for transplantation. The pancreas, and pancreatic islets in particular, is one of the most sensitive tissues towards hypoxia. The present study was aimed to assess the effect
Externí odkaz:
https://doaj.org/article/b41a0d285bae4a7c966ca4bef69d2c1c
Autor:
Samuel Acreman, Quan Zhang
Publikováno v:
Chronic Diseases and Translational Medicine, Vol 8, Iss 1, Pp 7-18 (2022)
Abstract Glucagon is a potent glucose‐elevating hormone that is secreted by pancreatic α‐cells. While well‐controlled glucagon secretion plays an important role in maintaining systemic glucose homeostasis and preventing hypoglycaemia, it is in
Externí odkaz:
https://doaj.org/article/2c8d1b93107c443285fda1a261fc9b0b
Autor:
Heide Brandhorst, Daniel Brandhorst, Anju Abraham, Samuel Acreman, Simen W. Schive, Hanne Scholz, Paul R.V. Johnson
Publikováno v:
Cell Transplantation, Vol 29 (2020)
Previous studies in rodents have indicated that function and survival of transplanted islets can be substantially improved by mesenchymal stem cells (MSC). The few human islet studies to date have confirmed these findings but have not determined whet
Externí odkaz:
https://doaj.org/article/f2ecfb862b264ea0b309c7e238346e38
Publikováno v:
Cell Transplantation, Vol 25 (2016)
Hypoxia is the main threat to morphological and functional integrity of isolated pancreatic islets. Lack of oxygen seems to be of particular importance for functionality of encapsulated islets. The present study was initiated as an experimental model
Externí odkaz:
https://doaj.org/article/b347001576fd4529ab253b32adaed111
Publikováno v:
Journal of Endocrinology.
Glucagon is the principal glucose-elevating hormone that forms the first-line defence against hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic glucose homeostasis. The cells that secrete glucagon, pancreatic
Autor:
Kerry McLaughlin, Samuel Acreman, Sameena Nawaz, Joseph Cutteridge, Anne Clark, Jakob G. Knudsen, Geoffrey Denwood, Aliya F. Spigelman, Jocelyn E. Manning Fox, Sumeet Pal Singh, Patrick E. MacDonald, Benoit Hastoy, Quan Zhang
Publikováno v:
McLaughlin, K, Acreman, S, Nawaz, S, Cutteridge, J, Clark, A, Knudsen, J G, Denwood, G, Spigelman, A F, Fox, J E M, Singh, S P, MacDonald, P E, Hastoy, B & Zhang, Q 2022, ' Loss of tetraspanin-7 expression reduces pancreatic β-cell exocytosis Ca 2+ sensitivity but has limited effect on systemic metabolism ', Diabetic Medicine, vol. 39, no. 12, e14984 . https://doi.org/10.1111/dme.14984
Background: Tetraspanin-7 (Tspan7) is an islet autoantigen involved in autoimmune type 1 diabetes and known to regulate beta-cell L-type Ca-2(+) channel activity. However, the role of Tspan7 in pancreatic beta-cell function is not yet fully understoo