Role of mu opioid receptor (MOR) agonist efficacy as a determinant of opioid antinociception in a novel assay of pain-depressed behavior in female and male mice

Autor: S. Stevens Negus, Hamid I. Akbarali, Minho Kang, Young K. Lee, Samuel A. Marsh, Edna J. Santos, Yan Zhang

Publikováno v: Frontiers in Pain Research, Vol 4 (2023)

IntroductionIntermediate efficacy mu opioid receptor (MOR) agonists have potential to retain analgesic effectiveness while improving safety, but the optimal MOR efficacy for effective and safe opioid analgesia is unknown. Preclinical assays of pain-d

Externí odkaz: https://doaj.org/article/0fed794aac7f4406ac14863185ec2712

Opioid Withdrawal Produces Sex-Specific Effects on Fentanyl-Versus-Food Choice and Mesolimbic Transcription

Autor: E. Andrew Townsend, R. Kijoon Kim, Hannah L. Robinson, Samuel A. Marsh, Matthew L. Banks, Peter J. Hamilton

Publikováno v: Biological Psychiatry Global Open Science, Vol 1, Iss 2, Pp 112-122 (2021)

Background: Opioid withdrawal is a key driver of opioid addiction and an obstacle to recovery. However, withdrawal effects on opioid reinforcement and mesolimbic neuroadaptation are understudied, and the role of sex is largely unknown. Methods: Male

Externí odkaz: https://doaj.org/article/ce21ed5b68954f398e9a8b6d818fc920

APOE and immunity:Research highlights

Autor: Courtney M. Kloske, Christopher J. Barnum, Andre F. Batista, Elizabeth M. Bradshaw, Adam M. Brickman, Guojun Bu, Jessica Dennison, Mary D. Gearon, Alison M. Goate, Christian Haass, Michael T. Heneka, William T. Hu, Lenique K. L. Huggins, Nahdia S. Jones, Radosveta Koldamova, Cynthia A. Lemere, Shane A. Liddelow, Edoardo Marcora, Samuel E. Marsh, Henrietta M. Nielsen, Kellen K. Petersen, Melissa Petersen, Stefanie D. Piña‐Escudero, Wei Qiao Qiu, Yakeel T. Quiroz, Eric Reiman, Claire Sexton, Malú Gámez Tansey, Julia TCW, Charlotte E. Teunissen, Betty M. Tijms, Rik van der Kant, Rebecca Wallings, Stacie C. Weninger, Whitney Wharton, Donna M. Wilcock, Tyler James Wishard, Susan L Worley, Henrik Zetterberg, Maria C. Carrillo

Publikováno v: Kloske, C M, Barnum, C J, Batista, A F, Bradshaw, E M, Brickman, A M, Bu, G, Dennison, J, Gearon, M D, Goate, A M, Haass, C, Heneka, M T, Hu, W T, Huggins, L K L, Jones, N S, Koldamova, R, Lemere, C A, Liddelow, S A, Marcora, E, Marsh, S E, Nielsen, H M, Petersen, K K, Petersen, M, Piña-Escudero, S D, Qiu, W Q, Quiroz, Y T, Reiman, E, Sexton, C, Tansey, M G M, Tcw, J, Teunissen, C E, Tijms, B M, van der Kant, R, Wallings, R, Weninger, S C, Wharton, W, Wilcock, D M, Wishard, T J, Worley, S L, Zetterberg, H & Carrillo, M C 2023, ' APOE and immunity : Research highlights ', Alzheimer's and Dementia, vol. 19, no. 6, pp. 2677-2696 . https://doi.org/10.1002/alz.13020
Alzheimer's and dementia 19(6), 2677-2696 (2023). doi:10.1002/alz.13020
Kloske, C M, Barnum, C J, Batista, A F, Bradshaw, E M, Brickman, A M, Bu, G, Dennison, J, Gearon, M D, Goate, A M, Haass, C, Heneka, M T, Hu, W T, Huggins, L K L, Jones, N S, Koldamova, R, Lemere, C A, Liddelow, S A, Marcora, E, Marsh, S E, Nielsen, H M, Petersen, K K, Petersen, M, Piña-Escudero, S D, Qiu, W Q, Quiroz, Y T, Reiman, E, Sexton, C, Tansey, M G, Tcw, J, Teunissen, C E, Tijms, B M, van der Kant, R, Wallings, R, Weninger, S C, Wharton, W, Wilcock, D M, Wishard, T J, Worley, S L, Zetterberg, H & Carrillo, M C 2023, ' APOE and immunity: Research highlights ', Alzheimer's and Dementia, vol. 19, no. 6, pp. 2677-2696 . https://doi.org/10.1002/alz.13020

INTRODUCTION: At the Alzheimer's Association's APOE and Immunity virtual conference, held in October 2021, leading neuroscience experts shared recent research advances on and inspiring insights into the various roles that both the apolipoprotein E ge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d9ff92093ab0b6d772041ff569c18f
https://research.vumc.nl/en/publications/823b40ac-c075-4456-8a2d-bdf139906d29

Effects of the 5-HT2A receptor antagonist volinanserin on head-twitch response and intracranial self-stimulation depression induced by different structural classes of psychedelics in rodents

Autor: Alaina M. Jaster, Harrison Elder, Samuel A. Marsh, Mario de la Fuente Revenga, S. Stevens Negus, Javier González-Maeso

Publikováno v: Psychopharmacology. 239:1665-1677

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3a3e1c0e171e8352ac23b394c404640
https://doi.org/10.1007/s00213-022-06092-x

Opioid Withdrawal Produces Sex-Specific Effects on Fentanyl-Versus-Food Choice and Mesolimbic Transcription

Autor: R. Kijoon Kim, Peter J. Hamilton, E. Andrew Townsend, Samuel A. Marsh, Hannah L. Robinson, Matthew L. Banks

Publikováno v: Biological Psychiatry Global Open Science, Vol 1, Iss 2, Pp 112-122 (2021)
Biol Psychiatry Glob Open Sci

Background Opioid withdrawal is a key driver of opioid addiction and an obstacle to recovery. However, withdrawal effects on opioid reinforcement and mesolimbic neuroadaptation are understudied, and the role of sex is largely unknown. Methods Male (n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf081d8c4598fba8f76ef3b2654c1ffb
http://www.sciencedirect.com/science/article/pii/S266717432100015X