Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Samuel A. Mantey"'
Autor:
Terry W. Moody, Lingaku Lee, Irene Ramos-Alvarez, Tatiana Iordanskaia, Samuel A. Mantey, Robert T. Jensen
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
G-protein-coupled receptors (GPCRs) are increasingly being considered as possible therapeutic targets in cancers. Activation of GPCR on tumors can have prominent growth effects, and GPCRs are frequently over-/ectopically expressed on tumors and thus
Externí odkaz:
https://doaj.org/article/9dc83171ba4748c3a0890f861c85137d
Autor:
Terry W. Moody, Nicole Tashakkori, Samuel A. Mantey, Paola Moreno, Irene Ramos-Alvarez, Marcello Leopoldo, Robert T. Jensen
Publikováno v:
Frontiers in Endocrinology, Vol 8 (2017)
While peptide antagonists for the gastrin-releasing peptide receptor (BB2R), neuromedin B receptor (BB1R), and bombesin (BB) receptor subtype-3 (BRS-3) exist, there is a need to develop non-peptide small molecule inhibitors for all three BBR. The BB
Externí odkaz:
https://doaj.org/article/89b118da576445d1a02a4cc4cbcd7c38
Publikováno v:
J Pharmacol Exp Ther
Allosteric ligands of various G-protein–coupled receptors are being increasingly described and are providing important advances in the development of ligands with novel selectivity and efficacy. These unusual properties allow expanded opportunities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::755b92f03e7447d997d5c45388daefd9
https://europepmc.org/articles/PMC9341266/
https://europepmc.org/articles/PMC9341266/
Publikováno v:
Cancer Research. 82:2688-2688
Bombesin (BB) is an autocrine growth factor for non-small cell lung cancer (NSCLC) cells. BB stimulates whereas the BB2 receptor (R) antagonist PD176252 inhibits NSCLC growth (Moody et al., Eur. J. Pharmacol; 2003; 474:21). The BB2R regulates the tra
Autor:
Óscar Lorenzo, Jesús Egido, Antonio Martín-Duce, Robert T. Jensen, Samuel A. Mantey, Raúl Sanz, Zaida Moreno-Villegas, Nieves González, César Aparicio, Sergio Portal-Núñez
Publikováno v:
Molecular and Cellular Endocrinology. 474:10-19
BRS-3 has an important role in glucose homeostasis. Its expression was reduced in skeletal muscle from obese and/or diabetic patients, and BRS-3 KO-mice developed obesity. In this work, focused on rat/human adipose tissue, BRS-3 gene-expression was l
Autor:
Robert T. Jensen, Terry W. Moody, Samuel A. Mantey, Suk Hee Lee, Paola Moreno, Irene Ramos-Álvarez
Publikováno v:
Peptides. 101:213-226
Human bombesin receptors, GRPR and NMBR, are two of the most frequently overexpressed G-protein-coupled-receptors by lung-cancers. Recently, GRPR/NMBR are receiving considerable attention because they act as growth factor receptors often in an autocr
Autor:
Robert T. Jensen, Lisa A. Ridnour, Irene Ramos-Álvarez, Samuel A. Mantey, Paula Moreno, David A. Wink, Terry W. Moody
Publikováno v:
Peptides. 90:90-99
Endothelin (ET)-1 is an important peptide in cancer progression stimulating cellular proliferation, tumor angiogenesis and metastasis. ET-1 binds with high affinity to the ET A receptor (R) and ET B R on cancer cells. High levels of tumor ET-1 and ET
Publikováno v:
Gastroenterology. 158:S-508
Publikováno v:
Gastroenterology. 158:S-1014
Autor:
Marcello Leopoldo, Taichi Nakamura, Paola Moreno, Terry W. Moody, Robert T. Jensen, Samuel A. Mantey, Enza Lacivita
Publikováno v:
Peptides. 64:55-61
Bombesin receptor subtype (BRS)-3 is a G protein coupled receptor (GPCR) for the bombesin (BB)-family of peptides. BRS-3 is an orphan GPCR and little is known of its physiological role due to the lack of specific agonists and antagonists. PD168368 is