Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Samuel A. Killackey"'
Autor:
Paul Y. Bi, Samuel A. Killackey, Linus Schweizer, Damien Arnoult, Dana J. Philpott, Stephen E. Girardin
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract Mitochondrial stress inducers such as carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and oligomycin trigger the DELE1-HRI branch of the integrated stress response (ISR) pathway. Previous studies performed using epitope-tagged DELE1 showed
Externí odkaz:
https://doaj.org/article/2c938dc33b884251b8cbcb518cef007c
Publikováno v:
Biomedical Journal, Vol 47, Iss 1, Pp 100635- (2024)
NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting conditions. Over the past fifteen years, NLRX1 has been proposed to r
Externí odkaz:
https://doaj.org/article/7b83b3daae22408cb5c490b114c21e9a
Autor:
Ivan Tattoli, Samuel A. Killackey, Elisabeth G. Foerster, Raphael Molinaro, Charles Maisonneuve, Muhammed A. Rahman, Shawn Winer, Daniel A. Winer, Catherine J. Streutker, Dana J. Philpott, Stephen E. Girardin
Publikováno v:
Cell Reports, Vol 14, Iss 11, Pp 2576-2586 (2016)
The mitochondrial Nod-like receptor protein NLRX1 protects against colorectal tumorigenesis through mechanisms that remain unclear. Using mice with an intestinal epithelial cells (IEC)-specific deletion of Nlrx1, we find that NLRX1 provides an IEC-in
Externí odkaz:
https://doaj.org/article/0516d2ca8656408cab832e57131bf2ae
Publikováno v:
BioTechniques, Vol 69, Iss 4, Pp 249-256 (2020)
Mitophagy is the process by which mitochondria are selectively targeted and removed via autophagic machinery to maintain mitochondrial homeostasis in the cell. Recently, flow cytometry-based assays that utilize the fluorescent mtKeima reporter system
Externí odkaz:
https://doaj.org/article/e22e909199ca4fd4a0f1d086eeefbedc
Autor:
Paul Y. Bi, Samuel A. Killackey, Linus Schweizer, Damien Arnoult, Dana J. Philpott, Stephen E. Girardin
Mitochondrial stress inducers, such as the proton ionophore carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and the ATPase pump inhibitor oligomycin, trigger the DELE1-HRI branch of the integrated stress response (ISR) pathway. Previous studies perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d330a45b51a1167530b122397ef742f1
https://doi.org/10.1101/2023.02.26.530105
https://doi.org/10.1101/2023.02.26.530105
Publikováno v:
Autophagy.
Mitochondria rely on efficient protein import across their membranes for optimal function. We have shown that numerous mitochondrial stressors all converge on a common pathway disrupting this import efficiency. We identified a novel pathway involving
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16665d620a1bc97fffe38610d5cde5d8
https://pubmed.ncbi.nlm.nih.gov/36170592
https://pubmed.ncbi.nlm.nih.gov/36170592
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 6 (2016)
Shigella is a Gram-negative bacterium that is responsible for shigellosis. Over the years, the study of Shigella has provided a greater understanding of how the host responds to bacterial infection, and how bacteria have evolved to effectively counte
Externí odkaz:
https://doaj.org/article/3c7fdf9c3d824a3b9218bdd09e0f3a82
Autor:
Samuel A, Killackey, Yuntian, Bi, Fraser, Soares, Ikram, Hammi, Nathaniel J, Winsor, Ali A, Abdul-Sater, Dana J, Philpott, Damien, Arnoult, Stephen E, Girardin
Publikováno v:
Molecular Cell. 82:2815-2831.e5
Protein import into mitochondria is a highly regulated process, yet how cells clear mitochondria undergoing dysfunctional protein import remains poorly characterized. Here we showed that mitochondrial protein import stress (MPIS) triggers localized L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5aeaac88f18f9cc6a2254770f8078494
https://doi.org/10.1016/j.molcel.2022.06.004
https://doi.org/10.1016/j.molcel.2022.06.004
Publikováno v:
The Journal of Cell Biology
Killackey et al. review recent advances and major questions in the field of mitophagy, as well as implications for mitophagy in disease.
Mitophagy is an evolutionarily conserved process involving the autophagic targeting and clearance of mitocho
Mitophagy is an evolutionarily conserved process involving the autophagic targeting and clearance of mitocho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606579c309321aa656a191712b3fbb04
http://europepmc.org/articles/PMC7594502
http://europepmc.org/articles/PMC7594502
Publikováno v:
BioTechniques. 69(4)
Mitophagy is the process by which mitochondria are selectively targeted and removed via autophagic machinery to maintain mitochondrial homeostasis in the cell. Recently, flow cytometry-based assays that utilize the fluorescent mtKeima reporter system
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90d1ab33737e141359f311815d7493ed
https://pubmed.ncbi.nlm.nih.gov/32806949
https://pubmed.ncbi.nlm.nih.gov/32806949