Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Samuel A Santoro"'
Autor:
Robin J Marjoram, Zhengzhi Li, Li He, Douglas M Tollefsen, Thomas J Kunicki, S Kent Dickeson, Samuel A Santoro, Mary M Zutter
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e114035 (2014)
Platelets express the α2β1 integrin and the glycoprotein VI (GPVI)/FcRγ complex, both collagen receptors. Understanding platelet-collagen receptor function has been enhanced through use of genetically modified mouse models. Previous studies of GPV
Externí odkaz:
https://doaj.org/article/a0186060a2c64848bb49810c27afac21
Autor:
Ambra Pozzi, José Carlos Pastor-Pareja, Gautam Bhave, Roy Zent, Billy G. Hudson, Celestial Jones-Paris, Selene Colon, A. Scott McCall, Kyle L. Brown, Elena Pokydeshava, Timothy S. Blackwell, Min Liu, Isi Ero-Tolliver, Vadim Pedchenko, Christopher F. Cummings, Samuel A. Santoro, Cody L. Stothers, Roberto M. Vanacore, Mohamed Rafi
Publikováno v:
The Journal of Cell Biology
Chloride is ubiquitous in physiology but understood to provide ionic strength for tissue function. The authors discover a molecular function of chloride whereby the ion signals the assembly of collagen IV, establishing a microenvironment on the outsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8b3f3be5476d4cf32b7d3fd570440d8
https://doi.org/10.1083/jcb.201510065
https://doi.org/10.1083/jcb.201510065
Optimizing Personalized Bone Marrow Testing Using an Evidence-Based, Interdisciplinary Team Approach
Autor:
Madan Jagasia, Edward R. Marx, Robert S. Dittus, William D. Dupont, Stephen A. Strickland, Mia A. Levy, Megan K. Kressin, Samuel A. Santoro, Adam C. Seegmiller, Mary M. Zutter, Nishitha Reddy, Kristy J. Sinkfield, Edward K. Shultz, W. Dale Plummer, Herschel N. Pollard, Mary Ann Thompson, Annette S. Kim, Claudio A. Mosse, William W. Stead
Publikováno v:
American Journal of Clinical Pathology. 140:643-650
Personalized medicine requires physicians to employ complex and expensive diagnostic analyses. However, without evidence-based standards, there is over-utilization of testing that complicates patient care, diminishes quality, and increases costs. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa506ba4da25e8db8f2e241125c92e87
https://doi.org/10.1309/ajcp8cke9neinqfl
https://doi.org/10.1309/ajcp8cke9neinqfl
Autor:
Samuel A. Santoro, Wade D. Van Horn, Roy Zent, Brandt F. Eichman, Mingjian Shi, Ambra Pozzi, Billy G. Hudson, Vadim Pedchenko, Briana H. Greer, Charles R. Sanders
Publikováno v:
Journal of Biological Chemistry. 287:35139-35152
Integrin α1β1 binding to collagen IV, which is mediated by the α1-inserted (I) domain, down-regulates collagen synthesis. When unligated, a salt bridge between Arg(287) and Glu(317) is thought to keep this domain in a low affinity conformation. Li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a0773d3f0eb9f35ec518260b92dc03
https://doi.org/10.1074/jbc.m112.358648
https://doi.org/10.1074/jbc.m112.358648
Autor:
Thomas Stricker, Lan Cheng, S. Kent Dickeson, Alec A. Schmaier, Mark L. Kahn, Samuel A. Santoro, Zhiying Zou, Patricia Mericko
Publikováno v:
Blood. 113:6428-6439
Circulating platelets exhibit rapid signaling and adhesive responses to collagen that facilitate hemostasis at sites of vessel injury. Because platelets are anuclear, their collagen receptors must be expressed by megakaryocytes, platelet precursors t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a19ef804592e0a2c0be248be37f322
https://doi.org/10.1182/blood-2008-08-175356
https://doi.org/10.1182/blood-2008-08-175356
Autor:
Zhengzhi Li, Thomas Stricker, S. Kent Dickeson, Virginia L. Shepherd, Samuel A. Santoro, Mary M. Zutter, Brian T. Edelson
Publikováno v:
Blood. 107:143-150
Mast cells play a critical role in innate immunity, allergy, and autoimmune diseases. The receptor/ligand interactions that mediate mast cell activation are poorly defined. The α2β1 integrin, a receptor for collagens, laminins, decorin, E-cadherin,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d65b3038ed8ca675f8aef5b77c737a
https://doi.org/10.1182/blood-2005-06-2218
https://doi.org/10.1182/blood-2005-06-2218
Autor:
Daniel A. Hammer, Mark L. Kahn, Samuel A. Santoro, Hong Chen, Mary M. Zutter, Kendra L. Sarratt
Publikováno v:
Blood. 106:1268-1277
The roles of the 2 major platelet-collagen receptors, glycoprotein VI (GPVI) and integrin α2β1, have been intensely investigated using a variety of methods over the past decade. In the present study, we have used pharmacologic and genetic approache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436fd3255e5534a57996dc94c5cebb38
https://doi.org/10.1182/blood-2004-11-4434
https://doi.org/10.1182/blood-2004-11-4434
Autor:
Renato V. Iozzo, Jian Fu, Magnus Höök, Jiyeun Kate Kim, Laura Macro, E González, Charles C. Reed, Mary M. Zutter, Shelly Campbell, Gregory J. Bix, Samuel A. Santoro, Amy Barker
Publikováno v:
The Journal of Cell Biology
Endorepellin, the COOH-terminal domain of the heparan sulfate proteoglycan perlecan, inhibits several aspects of angiogenesis. We provide evidence for a novel biological axis that links a soluble fragment of perlecan protein core to the major cell su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9b787dbb354ebef9047a098612190f
https://doi.org/10.1083/jcb.200401150
https://doi.org/10.1083/jcb.200401150
Autor:
Zengyi Zhou, Vito Quaranta, Jae Hong Im, Samuel A. Santoro, Vandana Iyer, Qian-Chun Yu, Hui Wang, C. Mike DiPersio, Weili Fu, Abu B. Al-Mehdi, Ruth J. Muschel
Publikováno v:
The Journal of Cell Biology
Arrest of circulating tumor cells in distant organs is required for hematogenous metastasis, but the tumor cell surface molecules responsible have not been identified. Here, we show that the tumor cell alpha3beta1 integrin makes an important contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d21d2ffd7176fa85ff30c8fb1e99f8f
https://doi.org/10.1083/jcb.200309112
https://doi.org/10.1083/jcb.200309112
Publikováno v:
The American Journal of Pathology. 161:337-344
The α2β1 integrin is a collagen/laminin receptor expressed on platelets, endothelial cells, fibroblasts, and epithelial cells. To define the role of the α2β1 integrin in vivo, we created a genetically engineered mouse in which expression of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c9dc88e216614b7ea20d42ba86d1392
https://doi.org/10.1016/s0002-9440(10)64185-5
https://doi.org/10.1016/s0002-9440(10)64185-5