Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Samuel, Virtue"'
Autor:
Vanessa Pellegrinelli, Elizabeth Figueroa-Juárez, Isabella Samuelson, Mueez U-Din, Sonia Rodriguez-Fdez, Samuel Virtue, Jennifer Leggat, Cankut Çubuk, Vivian J. Peirce, Tarja Niemi, Mark Campbell, Sergio Rodriguez-Cuenca, Joaquin Dopazo Blázquez, Stefania Carobbio, Kirsi A. Virtanen, Antonio Vidal-Puig
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112640- (2023)
Summary: The relevance of extracellular matrix (ECM) remodeling is reported in white adipose tissue (AT) and obesity-related dysfunctions, but little is known about the importance of ECM remodeling in brown AT (BAT) function. Here, we show that a tim
Externí odkaz:
https://doaj.org/article/abc6d1bed4df4ab1bb326033123fcdff
Autor:
Satish Patel, Afreen Haider, Anna Alvarez-Guaita, Guillaume Bidault, Julia Sarah El-Sayed Moustafa, Esther Guiu-Jurado, John A. Tadross, James Warner, James Harrison, Samuel Virtue, Fabio Scurria, Ilona Zvetkova, Matthias Blüher, Kerrin S. Small, Stephen O’Rahilly, David B. Savage
Publikováno v:
Molecular Metabolism, Vol 65, Iss , Pp 101589- (2022)
Objectives: Obesity in humans and mice is associated with elevated levels of two hormones responsive to cellular stress, namely GDF15 and FGF21. Over-expression of each of these is associated with weight loss and beneficial metabolic changes but wher
Externí odkaz:
https://doaj.org/article/86d575de029d49f1be5d61f2c525a70f
Autor:
Irene Cimino, Debra Rimmington, Y. C. Loraine Tung, Katherine Lawler, Pierre Larraufie, Richard G. Kay, Samuel Virtue, Brian Y. H. Lam, Luca Fagnocchi, Marcella K. L. Ma, Vladimir Saudek, Ilona Zvetkova, Antonio Vidal-Puig, Giles S. H. Yeo, I. Sadaf Farooqi, J. Andrew Pospisilik, Fiona M. Gribble, Frank Reimann, Stephen O’Rahilly, Anthony P. Coll
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract Neuronatin (Nnat) has previously been reported to be part of a network of imprinted genes downstream of the chromatin regulator Trim28. Disruption of Trim28 or of members of this network, including neuronatin, results in an unusual phenotype
Externí odkaz:
https://doaj.org/article/e7d5a888c2a540aeac4077803967b5d5
Autor:
Anna Whitehead, Fynn N. Krause, Amy Moran, Amanda D. V. MacCannell, Jason L. Scragg, Ben D. McNally, Edward Boateng, Steven A. Murfitt, Samuel Virtue, John Wright, Jack Garnham, Graeme R. Davies, James Dodgson, Jurgen E. Schneider, Andrew J. Murray, Christopher Church, Antonio Vidal-Puig, Klaus K. Witte, Julian L. Griffin, Lee D. Roberts
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)
Beige and brown fat may influence systemic metabolism through secreted signals. Here the authors identify a panel of metabolites secreted from beige and brown fat cells, which signal to influence fat tissue and skeletal muscle metabolism and have ant
Externí odkaz:
https://doaj.org/article/d473c1c97b044c2fb72f34ce9316e47f
Autor:
Samuel Furse, Samuel Virtue, Stuart G. Snowden, Antonio Vidal-Puig, Philip C. Stevenson, Davide Chiarugi, Albert Koulman
Publikováno v:
Molecular Metabolism, Vol 59, Iss , Pp 101457- (2022)
Objective: Polyunsaturated fatty acid (PUFA) supplements have been trialled as a treatment for a number of conditions and produced a variety of results. This variety is ascribed to the supplements, that often comprise a mixture of fatty acids, and to
Externí odkaz:
https://doaj.org/article/07370932cfd04abbb2b26d8fc678dc0e
Autor:
Marie-Therese Rached, Steven J. Millership, Silvia M.A. Pedroni, Agharul I. Choudhury, Ana S.H. Costa, Darran G. Hardy, Justyna A. Glegola, Elaine E. Irvine, Colin Selman, Megan C. Woodberry, Vijay K. Yadav, Sanjay Khadayate, Antonio Vidal-Puig, Samuel Virtue, Christian Frezza, Dominic J. Withers
Publikováno v:
Molecular Metabolism, Vol 20, Iss , Pp 38-50 (2019)
Objective: Sympathetic nervous system and immune cell interactions play key roles in the regulation of metabolism. For example, recent convergent studies have shown that macrophages regulate obesity through brown adipose tissue (BAT) activation and b
Externí odkaz:
https://doaj.org/article/5803aa224a3943529081e8fdb36d8b37
Autor:
Vian Azzu, Michele Vacca, Ioannis Kamzolas, Zoe Hall, Jack Leslie, Stefania Carobbio, Samuel Virtue, Susan E. Davies, Agnes Lukasik, Martin Dale, Mohammad Bohlooly-Y, Animesh Acharjee, Daniel Lindén, Guillaume Bidault, Evangelia Petsalaki, Julian L. Griffin, Fiona Oakley, Michael E.D. Allison, Antonio Vidal-Puig
Publikováno v:
Molecular Metabolism, Vol 48, Iss , Pp 101210- (2021)
Objective: Non-alcoholic fatty liver disease (NAFLD) is a silent pandemic associated with obesity and the metabolic syndrome, and also increases cardiovascular- and cirrhosis-related morbidity and mortality. A complete understanding of adaptive compe
Externí odkaz:
https://doaj.org/article/e22a0520a7ea4213a3c9346e79e25390
Autor:
Vanessa Pellegrinelli, Vivian J. Peirce, Laura Howard, Samuel Virtue, Dénes Türei, Martina Senzacqua, Andrea Frontini, Jeffrey W. Dalley, Antony R. Horton, Guillaume Bidault, Ilenia Severi, Andrew Whittle, Kamal Rahmouni, Julio Saez-Rodriguez, Saverio Cinti, Alun M. Davies, Antonio Vidal-Puig
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Enhancing thermogenesis is a promising therapeutic strategy for promoting metabolic health. Here the authors show that adipocyte-secreted BMP8b contributes to optimizing the thermogenic response by remodeling of the neuro-vascular networks in brown a
Externí odkaz:
https://doaj.org/article/5c42b2a14fae4857a4e5850a489dadfe
Autor:
Amandine Girousse, Samuel Virtue, Dan Hart, Antonio Vidal-Puig, Peter R. Murgatroyd, Etienne Mouisel, Coralie Sengenès, David B. Savage
Publikováno v:
Molecular Metabolism, Vol 13, Iss , Pp 24-29 (2018)
Objective: Surplus dietary fat cannot be converted into other macronutrient forms or excreted, so has to be stored or oxidized. Healthy mammals store excess energy in the form of triacylgycerol (TAG) in lipid droplets within adipocytes rather than ox
Externí odkaz:
https://doaj.org/article/f41570d6e49643ebad6dce0ceea8f84d
Autor:
Francis W. B. Sanders, Animesh Acharjee, Celia Walker, Luke Marney, Lee D. Roberts, Fumiaki Imamura, Benjamin Jenkins, Jack Case, Sumantra Ray, Samuel Virtue, Antonio Vidal-Puig, Diana Kuh, Rebecca Hardy, Michael Allison, Nita Forouhi, Andrew J. Murray, Nick Wareham, Michele Vacca, Albert Koulman, Julian L. Griffin
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background Diet is a major contributor to metabolic disease risk, but there is controversy as to whether increased incidences of diseases such as non-alcoholic fatty liver disease arise from consumption of saturated fats or free sugars. Here
Externí odkaz:
https://doaj.org/article/5db6aaf176ce4f6e80bbbd5ee0692bd0