Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Samuel, Herberg"'
Autor:
Souvik Ghosh, Samuel Herberg
Publikováno v:
Biomaterials and Biosystems, Vol 13, Iss , Pp 100091- (2024)
This review highlights the importance of extracellular matrix (ECM) biomaterials in understanding the biology of human trabecular meshwork (TM) and Schlemm's canal (SC) cells under normal and simulated glaucoma-like conditions. We provide an overview
Externí odkaz:
https://doaj.org/article/884cabe066f6478890bb242ac998e5cc
Autor:
Samuel Herberg, Daniel Varghai, Daniel S. Alt, Phuong N. Dang, Honghyun Park, Yuxuan Cheng, Jung-Youn Shin, Anna D. Dikina, Joel D. Boerckel, Marsha W. Rolle, Eben Alsberg
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Herberg et al. previously showed functional healing of femoral defects using scaffold-free human mesenchymal stem cell (hMSC) condensates with localized morphogen presentation. In this study, they report the importance of the tubular geometry of MSC
Externí odkaz:
https://doaj.org/article/ca034ebc68764f5a85b780ac8aa721e4
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Primary open-angle glaucoma progression is associated with increased human trabecular meshwork (HTM) stiffness and elevated transforming growth factor beta 2 (TGFβ2) levels in the aqueous humor. Increased transcriptional activity of Yes-associated p
Externí odkaz:
https://doaj.org/article/bc79149058f74ffa90eb3bfd0b89518f
Autor:
Haiyan, Li, Jessica L, Henty-Ridilla, Audrey M, Bernstein, Preethi S, Ganapathy, Samuel, Herberg
Publikováno v:
Current eye research. 47(8)
Transforming growth factor-beta 2 (TGFβ2) is a major contributor to the pathologic changes occurring in human trabecular meshwork (HTM) cells in primary open-angle glaucoma (POAG). TGFβ2 activates extracellular-signal-regulated kinase (ERK) and Rho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ab06adcac958f2c054d5604a32528162
https://pubmed.ncbi.nlm.nih.gov/35481448
https://pubmed.ncbi.nlm.nih.gov/35481448
Autor:
Haiyan Li, Jessica L. Henty-Ridilla, Audrey M. Bernstein, Preethi S. Ganapathy, Samuel Herberg
Publikováno v:
Current Eye Research. 47:1165-1178
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89dc9912f66aa9153de4a594cb5f8e7c
https://doi.org/10.1080/02713683.2022.2071943
https://doi.org/10.1080/02713683.2022.2071943
Autor:
Hannah Yoo, Ayushi Singh, Haiyan Li, Ana N. Strat, Tyler Bagué, Preethi S. Ganapathy, Samuel Herberg
PurposeImpairment of the trabecular meshwork (TM) is the principal cause of increased outflow resistance in the glaucomatous eye. Yes-associated protein (YAP) and transcriptional coactivator with PDZ binding motif (TAZ) are emerging as potential medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed82d54d673bb67b762d3ce2d9032c32
https://doi.org/10.1101/2022.09.27.509788
https://doi.org/10.1101/2022.09.27.509788
Autor:
Tyler Bagué, Ayushi Singh, Rajanya Ghosh, Hannah Yoo, Curtis Kelly, Mitchell A. deLong, Casey C. Kopczynski, Samuel Herberg
Publikováno v:
Frontiers in Ophthalmology. 2
Interactions between trabecular meshwork (TM) cells and their extracellular matrix (ECM) are critical for normal outflow function in the healthy eye. Multifactorial dysregulation of the TM is the principal cause of elevated intraocular pressure that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6bd9949087ee39bb040adf3bb33d75c
https://doi.org/10.3389/fopht.2022.948397
https://doi.org/10.3389/fopht.2022.948397
Autor:
Haiyan Li, Ayushi Singh, Kristin M. Perkumas, W. Daniel Stamer, Preethi S. Ganapathy, Samuel Herberg
PurposeElevated transforming growth factor beta2 (TGFβ2) levels in the aqueous humor have been linked to glaucomatous outflow tissue dysfunction. Potential mediators of dysfunction are the transcriptional co-activators, Yes-associated protein (YAP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a64599071edd1575f4ed62a66b0d2d74
https://doi.org/10.1101/2022.06.06.494681
https://doi.org/10.1101/2022.06.06.494681
Publikováno v:
Frontiers in cell and developmental biology. 10
Primary open-angle glaucoma progression is associated with increased human trabecular meshwork (HTM) stiffness and elevated transforming growth factor beta 2 (TGFβ2) levels in the aqueous humor. Increased transcriptional activity of Yes-associated p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a78ee94ad0bbf399868f2bf45daf694
https://pubmed.ncbi.nlm.nih.gov/35300422
https://pubmed.ncbi.nlm.nih.gov/35300422
Autor:
Haiyan Li, John Yablonski, Preethi S. Ganapathy, Tyler Bague, Alexander Kirschner, Samuel Herberg, Jing Zhao, Kathryn E. Bollinger, Hannah Yoo, Ana N. Strat
Publikováno v:
Exp Eye Res
Astrocytes within the optic nerve head undergo actin cytoskeletal rearrangement early in glaucoma, which coincides with astrocyte reactivity and extracellular matrix (ECM) deposition. Elevated transforming growth factor beta 2 (TGFβ2) levels within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad77ac87c2100dded2c8ae4fbca56a23
https://europepmc.org/articles/PMC9192100/
https://europepmc.org/articles/PMC9192100/