Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Samuel, Génier"'
Autor:
Christine Lavoie, Jade Degrandmaison, Véronique Blais, Jim Boulter, Jean-Luc Parent, Samuel Génier, Khaled Abdallah, Louis Gendron, Catherine M. Cahill, Francis Bergeron, Marie-Pier Lalumière
Publikováno v:
Proc Natl Acad Sci U S A
With over 30% of current medications targeting this family of proteins, G-protein–coupled receptors (GPCRs) remain invaluable therapeutic targets. However, due to their unique physicochemical properties, their low abundance, and the lack of highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e552663e1b33fafd3197dc42e973a4a1
https://doi.org/10.1073/pnas.1917906117
https://doi.org/10.1073/pnas.1917906117
Autor:
Jade Degrandmaison, Samuel Picard, Louis Fréchette, Samuel Génier, Jean-Luc Parent, Chantal Binda, Steve Jean, Eric Marsault
Publikováno v:
J Biol Chem
Accumulating evidence indicates that G protein–coupled receptors (GPCRs) interact with Rab GTPases during their intracellular trafficking. How GPCRs recruit and activate the Rabs is unclear. Here, we report that depletion of endogenous L-type prost
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ddf0adca4608ae8d0287405f29be38
https://doi.org/10.1074/jbc.ra119.008233
https://doi.org/10.1074/jbc.ra119.008233
Autor:
Louis, Fréchette, Chantal, Binda, Samuel, Génier, Jade, Degrandmaison, Marilou, Boisvert, Jean-Luc, Parent
Publikováno v:
Cellular signalling. 72
Mechanisms controlling the recycling of G protein-coupled receptors (GPCRs) remain largely unclear. We report that GGA3 (Golgi-associated, γ adaptin ear containing, ADP-ribosylation factor-binding protein 3) regulates the recycling and signaling of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bbfce2ad6cffd94831cc4bd80b89fb62
https://pubmed.ncbi.nlm.nih.gov/32334026
https://pubmed.ncbi.nlm.nih.gov/32334026
Autor:
Jean-Luc Parent, Véronique Blais, Christine Lavoie, Samuel Génier, Louis Gendron, Jade Degrandmaison, Sébastien Grastilleur, Étienne St-Louis
Publikováno v:
Molecular and Cellular Neuroscience. 79:53-63
The delta opioid receptor (DOPr) is known to be mainly expressed in intracellular compartments. It remains unknown why DOPr is barely exported to the cell surface, but it seems that a substantial proportion of the immature receptor is trapped within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3465d08205d2817491b39b739395f97d
https://doi.org/10.1016/j.mcn.2016.12.005
https://doi.org/10.1016/j.mcn.2016.12.005
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1947
G protein-coupled receptors (GPCRs) contain highly hydrophobic domains that are subject to aggregation when exposed to the crowded environment of the cytoplasm. Many events can lead to protein aggregation such as mutations, endoplasmic reticulum (ER)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ddc90606ee38184c2368276e0086b013
https://pubmed.ncbi.nlm.nih.gov/30969423
https://pubmed.ncbi.nlm.nih.gov/30969423
Publikováno v:
Methods in Molecular Biology ISBN: 9781493991204
G protein-coupled receptors (GPCRs) contain highly hydrophobic domains that are subject to aggregation when exposed to the crowded environment of the cytoplasm. Many events can lead to protein aggregation such as mutations, endoplasmic reticulum (ER)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ba0435c47070e011b76bfd8a2edff77
https://doi.org/10.1007/978-1-4939-9121-1_16
https://doi.org/10.1007/978-1-4939-9121-1_16
Autor:
Pascale Labrecque, Jean-Luc Parent, Terence E. Hébert, Samuel Génier, Pierrick Moreau, Jade Degrandmaison
Publikováno v:
Molecular Biology of the Cell
A direct and functional interaction between a subunit of the CCT/TCP-1 ring complex (TRiC) chaperonin complex and G protein–coupled receptor (GPCRs) is shown. Evidence is provided that distinct nascent GPCRs can undergo alternative folding pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d714d647291e0fc4239b35a6d687ddd
http://europepmc.org/articles/PMC5170604
http://europepmc.org/articles/PMC5170604
Autor:
Pierre Lavigne, Samuel Génier, Esther Gauthier, Samuel Picard, Jean-Luc Parent, Danny Létourneau, Marilou Boisvert
Publikováno v:
Journal of Structural Biology. 212:107582
Rab4a is a small GTPase associated with endocytic compartments and a key regulator of early endosomes recycling. Gathering evidence indicates that its expression and activation are required for the development of metastases. Rab4a-intrinsic GTPase pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbb98d34cc4516c03b0e3cbf1657bcfc
https://doi.org/10.1016/j.jsb.2020.107582
https://doi.org/10.1016/j.jsb.2020.107582
Autor:
Samuel Génier, Jean-Luc Parent, Louis Fréchette, Marilou Boisvert, Chantal Binda, Jade Degrandmaison
Publikováno v:
Cellular Signalling. 72:109641
Mechanisms controlling the recycling of G protein-coupled receptors (GPCRs) remain largely unclear. We report that GGA3 (Golgi-associated, γ adaptin ear containing, ADP-ribosylation factor-binding protein 3) regulates the recycling and signaling of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cedd097dec3826f93e7e2763a8b4b8e
https://doi.org/10.1016/j.cellsig.2020.109641
https://doi.org/10.1016/j.cellsig.2020.109641
Autor:
Jean-Luc Parent, Jason C. Young, Andréane Cartier, Jean-François Larrivée, Jana Stankova, Samuel Génier, Chantal Binda
Publikováno v:
The Journal of Cell Biology
The GPCR DP1 promotes the activity of L-PGDS, the enzyme that produces the DP1 agonist PGD2, while at the same time L-PGDS promotes the export and activity of DP1 in response to PGD2.
Export of newly synthesized G protein–coupled receptors (GP
Export of newly synthesized G protein–coupled receptors (GP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39d40a910b027c07f751f689cbbfb69
http://europepmc.org/articles/PMC3912537
http://europepmc.org/articles/PMC3912537