Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Samuel, Egieyeh"'
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Tuberculosis remains one of the causes of death from a single infectious bacterium. The inappropriate use of antibiotics and patients’ non-compliance among other factors drive the emergence of drug-resistant tuberculosis. Multidrug-resistant and ex
Externí odkaz:
https://doaj.org/article/80456377bf34440ca70adfdd67035f7c
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245258 (2021)
Drug repurposing for COVID-19 has several potential benefits including shorter development time, reduced costs and regulatory support for faster time to market for treatment that can alleviate the current pandemic. The current study used molecular do
Externí odkaz:
https://doaj.org/article/357738ac9a5143d18b927a011a06f025
Autor:
Ninon G. E. R. Etsassala, Jelili A. Badmus, Jeanine L. Marnewick, Samuel Egieyeh, Emmanuel. I. Iwuoha, Felix Nchu, Ahmed A. Hussein
Publikováno v:
Antioxidants, Vol 11, Iss 2, p 378 (2022)
Shortage in insulin secretion or degradation of produced insulin is the principal characteristic of the metabolic disorder of diabetes mellitus (DM). However, because the current medications for the treatment of DM have many detrimental side effects,
Externí odkaz:
https://doaj.org/article/f9a4f8dca706465f99195e3f55b7a68d
Publikováno v:
Viruses, Vol 13, Iss 10, p 2095 (2021)
Advances in nanotechnology have enabled the development of a new generation of vaccines, which are playing a critical role in the global control of the COVID-19 pandemic and the return to normalcy. Vaccine development has been conducted, by and large
Externí odkaz:
https://doaj.org/article/80fb038ac2d54793bcbdc3fcf2b1d0ae
Alzheimer’s disease (AD), a progressive neurodegenerative health condition symptomized by dementia is characterized majorly by the accumulation of Aβ peptides and Tau hyperphosphorylation. AD also progresses as a result of oxidative stress caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2434e8b7a509ce34211ab9fb4558ddb
https://doi.org/10.22541/au.168422444.44744526/v1
https://doi.org/10.22541/au.168422444.44744526/v1
Autor:
Admire Dube, Retsepile E. Maphasa, RB Bekale, Samuel Egieyeh, AF Irabin, SM Du Plessis, Sarah D’Souza, Samantha L. Sampson
Publikováno v:
Journal of pharmaceutical sciences
Nanoparticles (NPs) that can activate macrophages infected with the tuberculosis causative pathogen Mycobacterium tuberculosis, could be an effective host directed therapy for the disease. In this study, curdlan was conjugated to poly(lactic-co-glyco
Publikováno v:
Chemical Biology & Drug Design. 99:674-687
Identifying novel lead compounds in drug discovery has been challenging because of the rapid rise of drug resistance to the existing chemotherapeutics and a lack of understanding of complex metabolic pathways in the parasite. Integrating computationa
Publikováno v:
PLoS ONE, Vol 13, Iss 9, p e0204644 (2018)
In view of the vast number of natural products with potential antiplasmodial bioactivity and cost of conducting antiplasmodial bioactivity assays, it may be judicious to learn from previous antiplasmodial bioassays and predict bioactivity of these na
Externí odkaz:
https://doaj.org/article/310ed2d4de3641429be47091a8bc8069
Autor:
Erika Kapp, Hanri Calitz, Elizabeth M. Streicher, Anzaan Dippenaar, Samuel Egieyeh, Audrey Jordaan, Digby F. Warner, Jacques Joubert, Sarel F. Malan, Samantha L. Sampson
Publikováno v:
Tuberculosis. 141:102350
Autor:
Moses Ikegbunam, InnocentMary Ejiofor, Vincent Duru, Amarachi Akachukwu, Emmanual Oranu, Jude Nnaemeka Okoyeh, Samuel Egieyeh
Resistance to Pyrimethamine, an antimalarial medicine has been reported to be due to mutations in Dihydrofolate reductase-thymidylate synthase (DHFR-TS). Phytochemicals, particularly from plants that been used in ethnomedicine, have been reported to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9866e8c2d17fecc2c31d0b3c0d9e396
https://doi.org/10.20944/preprints202202.0107.v1
https://doi.org/10.20944/preprints202202.0107.v1