Zobrazeno 1 - 10 of 97 pro vyhledávání: '"Samuel, Deutsch"'
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Akademický článek
A plant host, Nicotiana benthamiana, enables the production and study of fungal lignin-degrading enzymes
Autor: Nikita A. Khlystov, Yasuo Yoshikuni, Samuel Deutsch, Elizabeth S. Sattely
Publikováno v: Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Khlystov et al. introduce a new plant-based system (N. benthamiana) as a platform to rapidly produce a diverse array of recombinant fungal lignin-degrading enzymes. This study provides an initial framework to better understand the coordinated efforts
Externí odkaz: https://doaj.org/article/9d76764fd297425ca0a8c47f8f58a487
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A Synthetic Gene Library Yields a Previously Unknown Glycoside Phosphorylase That Degrades and Assembles Poly-β-1,3-GlcNAc, Completing the Suite of β-Linked GlcNAc Polysaccharides
Autor: Spencer S. Macdonald, Jose H. Pereira, Feng Liu, Gregor Tegl, Andy DeGiovanni, Jacob F. Wardman, Samuel Deutsch, Yasuo Yoshikuni, Paul D. Adams, Stephen G. Withers
Publikováno v: ACS central science, vol 8, iss 4
The considerable utility of glycoside phosphorylases (GPs) has led to substantial efforts over the past two decades to expand the breadth of known GP activities. Driven largely by the increase of available genomic DNA sequence data, the gap between t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55a371980bbe30d65b13f87de086838c
https://doi.org/10.1021/acscentsci.1c01570
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Intersubunit Coupling Enables Fast CO2-Fixation by Reductive Carboxylases
Autor: Hasan DeMirci, Yashas Rao, Gabriele M. Stoffel, Bastian Vögeli, Kristina Schell, Aharon Gomez, Alexander Batyuk, Cornelius Gati, Raymond G. Sierra, Mark S. Hunter, E. Han Dao, Halil I. Ciftci, Brandon Hayes, Fredric Poitevin, Po-Nan Li, Manat Kaur, Kensuke Tono, David Adrian Saez, Samuel Deutsch, Yasuo Yoshikuni, Helmut Grubmüller, Tobias J. Erb, Esteban Vöhringer-Martinez, Soichi Wakatsuki
Publikováno v: ACS central science, vol 8, iss 8
ACS Central Science
Enoyl-CoA carboxylases/reductases (ECRs) are some of the most efficient CO2-fixing enzymes described to date. However, the molecular mechanisms underlying the extraordinary catalytic activity of ECRs on the level of the protein assembly remain elusiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05fa966255720bcfdf2395cc9e451cb7
https://escholarship.org/uc/item/9064b000
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Abstract LB346: Mapping of shared tumor antigen reactivity with nanoparticle encapsulated mRNA in prostate cancer patients
Autor: Elena Montauti, Ole Haabeth, Chris Rae, Samuel Deutsch, Lawrence Fong, David Oh
Publikováno v: Cancer Research. 83:LB346-LB346
Background: Prostate cancer (PC) remains refractory immune checkpoint therapies (CPT) despite having an FDA-approved cancer vaccine. PC is known to have a low mutation burden resulting in low level of neoantigens, so shared tumor associated antigens
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e137d60ff883e703e199d42929bacc5f
https://doi.org/10.1158/1538-7445.am2023-lb346
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Abstract 5163: Local delivery of mRNA immunotherapy encoding HPV16 antigen, IL-12, and LIGHT/TNFSF14 results in superior immunogenicity and tumor clearance in a murine model of HPV16-driven cancer
Autor: Weiqun Liu, Diane M. Da Silva, Edward E. Lemmens, Colin J. McKinlay, Sangeeta Nath, Meredith L. Leong, Samuel Deutsch, W. Martin Kast, Ole Audun W. Haabeth
Publikováno v: Cancer Research. 83:5163-5163
While intramuscular vaccination with HPV16 antigens has been shown to induce robust tumor-specific immune responses in the periphery, this has led to limited efficacy in the clinic. One potential explanation is the lack of sufficient infiltration of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ec1be87a217be94483affc94feca5020
https://doi.org/10.1158/1538-7445.am2023-5163
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Abstract 690: Modification of mRNA-encoded HPV16 antigens to include endolysosomal trafficking domains drives cross-presentation and results in superior in vivo and ex vivo antigen-specific responses
Autor: Weiqun Liu, Daniel Fernandez, Colin J. McKinlay, Daniel O. Frimannsson, Meredith L. Leong, W. Martin Kast, Samuel Deutsch, Ole Audun W. Haabeth
Publikováno v: Cancer Research. 83:690-690
Many cancer immunotherapies require the strong activation of the T-cell mediated adaptive immune response to elicit their full anti-tumor potential. Antigen processing and presentation is a complex, multistep process that can be significantly enhance
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf4c32526736b7eb9cdba5e7cd6dd96f
https://doi.org/10.1158/1538-7445.am2023-690
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Manipulating the 3D organization of the largest synthetic yeast chromosome
Autor: Weimin Zhang, Luciana Lazar-Stefanita, Hitoyoshi Yamashita, Michael J. Shen, Leslie A. Mitchell, Hikaru Kurasawa, Max A. B. Haase, Xiaoji Sun, Qingwen Jiang, Stephanie L. Lauer, Laura H. McCulloch, Yu Zhao, David Ichikawa, Nicole Easo, S. Jiaming Lin, Viola Fanfani, Brendan R. Camellato, Yinan Zhu, Jitong Cai, Zhuwei Xu, Maya Sacasa, Ryan Accardo, Ju Young Ahn, Surekha Annadanam, Leighanne A. Brammer Basta, Nicholas R. Bello, Lousanna Cai, Stephanie Cerritos, MacIntosh Cornwell, Anthony D’Amato, Maria Hacker, Kenneth Hersey, Emma Kennedy, Ardeshir Kianercy, Dohee Kim, Hong Seo Lim, Griffin McCutcheon, Kimiko McGirr, Nora Meaney, Lauren Meyer, Ally Moyer, Maisa Nimer, Carla Sabbatini, Lisa Scheifele, Lucas S. Shores, Cassandra Silvestrone, Arden Snee, Antonio Spina, Anthony Staiti, Matt Stuver, Elli Tian, Danielle Whearty, Calvin Zhao, Tony Zheng, Vivian Zhou, Karen Zeller, Joel S. Bader, Giovanni Stracquadanio, Samuel Deutsch, Junbiao Dai, Yasunori Aizawa, Jef D. Boeke
SummaryWhether synthetic genomes can power life has attracted broad interest in the synthetic biology field, especially when the synthetic genomes are extensively modified with thousands of designer features. Here we report de novo synthesis of the l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f6dbba20f40851fd5c93f58596588a
https://doi.org/10.1101/2022.04.09.487066
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