Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Samuel, Chacko"'
Autor:
Michael R. Ruggieri, Samuel Chacko, Chellappagounder Thangavel, Deepak A. Deshpande, Jagmohan Singh, Ettickan Boopathi, Joseph A. Hypolite, Stephen A. Zderic, Elham Javed, Ruth Birbe, Nagat Frara, Ipsita Mohanty, Robert B. Den, Alan S. Braverman, Satish Rattan, Raymond B. Penn
Publikováno v:
FASEB J
Bladder dysfunction is associated with the overexpression of the intermediate filament (IF) proteins desmin and vimentin in obstructed bladder smooth muscle (BSM). However, the mechanisms by which these proteins contribute to BSM dysfunction are not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b157b8c223b1b089188f3d02ca3246da
https://europepmc.org/articles/PMC7018560/
https://europepmc.org/articles/PMC7018560/
Autor:
Stephen A. Zderic, Cristiano Mendes Gomes, Samuel Chacko, Deepak A. Deshpande, Chellappagounder Thangavel, Sankar Addya, Elham Javed, Raymond B. Penn, Ruth Birbe, Sreya Das, Robert B. Den, Ettickan Boopathi, Satish Rattan, Jagmohan Singh
Caveolins (CAVs) are structural proteins of caveolae that function as signaling platforms to regulate smooth muscle contraction. Loss of CAV protein expression is associated with impaired contraction in obstruction-induced bladder smooth muscle (BSM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e70cf18672d2996784bc4663dafc3560
https://europepmc.org/articles/PMC6458544/
https://europepmc.org/articles/PMC6458544/
Autor:
Alan J. Wein, Darshan P. Patel, Bruce Malkowicz, Samuel Chacko, Stephen A. Zderic, Ettickan Boopathi, Ranjita Chakrabarti, Cristiano Cristiano Gomes
Publikováno v:
American Journal of Physiology-Cell Physiology. 307:C542-C553
Partial bladder outlet obstruction (pBOO)-induced remodeling of bladder detrusor smooth muscle (DSM) is associated with the modulation of cell signals regulating contraction. We analyzed the DSM from obstructed murine urinary bladders for the tempora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d3618c6a309a9effabbcf4b6f0d14a3
https://doi.org/10.1152/ajpcell.00033.2014
https://doi.org/10.1152/ajpcell.00033.2014
Autor:
Maoxian Deng, Ettickan Boopathi, Alan J. Wein, Samuel Chacko, Shaohua Chang, Stephen A. Zderic, Tobias Raabe, Joseph A. Hypolite
Publikováno v:
American Journal of Physiology-Renal Physiology. 305:F1455-F1465
Caldesmon (CaD), a component of smooth muscle thin filaments, binds actin, tropomyosin, calmodulin, and myosin and inhibits actin-activated ATP hydrolysis by smooth muscle myosin. Internal deletions of the chicken CaD functional domain that spans fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913cb8d36be0f487ecd199fb7429ced9
https://doi.org/10.1152/ajprenal.00174.2013
https://doi.org/10.1152/ajprenal.00174.2013
Autor:
Maureen Basha, Sunish Mohanan, Joseph A. Hypolite, Samuel Chacko, Nicholas J. Laping, James O. Marx, Shaohua Chang, Stephen A. Zderic, Alan J. Wein
Publikováno v:
International Journal of Urology. 21:319-324
Objectives To study the relationship between myosin light chain phosphorylation of the detrusor muscle and spontaneous smooth muscle contractions in a rabbit model of partial outlet obstruction. Methods New Zealand white rabbit urinary bladders were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f8fbeb75acae10abbc7a78f4b7fcc44
https://doi.org/10.1111/iju.12247
https://doi.org/10.1111/iju.12247
Publikováno v:
Journal of Urology. 195
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf98b4f6a3cc883b40deebf58e1e0001
https://doi.org/10.1016/j.juro.2016.02.1713
https://doi.org/10.1016/j.juro.2016.02.1713
Autor:
Ettickan Boopathi, Shankar Addya, Elham Javed, Alan J. Wein, Stephen A. Zderic, Paolo Fortina, Samuel Chacko
Publikováno v:
Translational Andrology and Urology
Objective Urinary bladder smooth muscle (UBSM) displays spontaneous action potentials and this potential is related to the phasic nature of spontaneous contractions in this tissue. The amplitude of a phasic contraction depends on the increase in Ca2+
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77877b4af1a8ab5d69ae9a061cdb3dc4
http://europepmc.org/articles/PMC5143274
http://europepmc.org/articles/PMC5143274
Autor:
Samuel Chacko, Matthias Oelke, Ruth Kirschner-Hermanns, Firouz Daneshgari, Lori A. Birder, Bahareh Vahabi
Publikováno v:
Neurourology and Urodynamics. 31:359-364
Aims Due to an increase in aging population and changing eating habits diabetes mellitus (DM) type II is a rapidly increasing condition worldwide. Although not so detrimental as other co-morbidities, uropathy contributes to a significantly reduced qu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eea0ea875cf52351c87b3743e4a5ce9e
https://doi.org/10.1002/nau.22228
https://doi.org/10.1002/nau.22228
Autor:
Samuel Chacko, Stephen A. Zderic
Publikováno v:
Journal of Cellular and Molecular Medicine
The contractile properties of the urinary bladder are changed by the conditions of normal development and partial bladder outlet obstruction. This change in the contractile phenotype is accompanied by changes in the regulatory cascades and filaments
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fec673a74a892f4e4e07a770bdc27b2
https://doi.org/10.1111/j.1582-4934.2011.01368.x
https://doi.org/10.1111/j.1582-4934.2011.01368.x
Autor:
S. Bruce Malkowicz, Sandra Burkett, Ettickan Boopathi, Shaohua Chang, Samuel Chacko, Yongmu Zheng, Mary John
Publikováno v:
In Vitro Cellular & Developmental Biology - Animal. 48:84-96
We report a cell line (hBSM) established from human urinary bladder wall smooth muscle that maintains most of the phenotypic characteristics of smooth muscle cells. Cells were dissociated from the muscular layer with collagenase (1 mg/ml) and collect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760e207534e9d0f96baa312aa0c18ae5
https://doi.org/10.1007/s11626-011-9473-9
https://doi.org/10.1007/s11626-011-9473-9