Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Samson J. Koelle"'
Publikováno v:
Nature Computational Science. 1:280-289
Clonal tracking methods provide quantitative insights into the cellular output of genetically labeled progenitor cells across time and cellular compartments. In the context of gene and cell therapies, clonal tracking methods have enabled the tracking
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e691e46259ce3afc24ae7a3296d08b
https://doi.org/10.1038/s43588-021-00057-4
https://doi.org/10.1038/s43588-021-00057-4
Autor:
Samson J. Koelle, Idalia M. Yabe, Michael Ginsberg, Diego A. Espinoza, Chuanfeng Wu, Kyung-Rok Yu, Adam Glaser, So Gun Hong, Lauren L. Truitt, Mark E. Metzger, Allen E. Krouse, Sandhya R. Panch, Cynthia E. Dunbar, Stephanie Sellers, Pradeep K. Dagur, Sandeep Kumar Srivastava, Robert E. Donahue, Aylin C. Bonifacino, Daniel J. Nolan
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 703-715 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 703-715 (2021)
Ex vivo hematopoietic stem and progenitor cell (HSPC) expansion platforms are under active development, designed to increase HSPC numbers and thus engraftment ability of allogeneic cord blood grafts or autologous HSPCs for gene therapies. Murine and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759590d5a7af67044c39f4f1c32c3005
https://doi.org/10.1016/j.omtm.2021.02.009
https://doi.org/10.1016/j.omtm.2021.02.009
Clonal tracking methods provide quantitative insights into the cellular output of genetically labelled progenitor cells across time and cellular compartments. In the context of gene and cell therapies, clonal tracking methods have enabled the trackin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28b35d824c6c30f8550959100c9cf0c5
https://doi.org/10.1101/2020.07.23.212787
https://doi.org/10.1101/2020.07.23.212787
Autor:
Jayasri G. Iyer, Robert H. Pierce, Raphael Gottardo, Paul Nghiem, Natalie Vandeven, Aric Colunga, Valentin Voillet, Cassian Yee, Daniel Hunter, Phil Greenberg, Samson J. Koelle, Felecia Wagener, Holly N. Thomas, William J. Valente, Candice D. Church, Jason H. Bielas, Kelly G. Paulson, Megan S. McAfee, Shailender Bhatia, M. Perdicchio, Rima M. Kulikauskas, Aude G. Chapuis, David M. Koelle
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Understanding mechanisms of late/acquired cancer immunotherapy resistance is critical to improve outcomes; cellular immunotherapy trials offer a means to probe complex tumor–immune interfaces through defined T cell/antigen interactions. We treated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d89f08d5980d04456c2aecdd5cdcdebe
https://doaj.org/article/473d7b036b4c408a879dd4df2f3e7eb3
https://doaj.org/article/473d7b036b4c408a879dd4df2f3e7eb3
Autor:
Robert E. Donahue, So Gun Hong, Allen E. Krouse, Lauren L. Truitt, Idalia M. Yabe, Sandhya R. Panch, Kyung-Rok Yu, Chuanfeng Wu, Samson J. Koelle, Rong Lu, Aylin C. Bonifacino, Cynthia E. Dunbar, Xing Fan, Diego A. Espinoza, Tae-Hoon Shin, Mark E. Metzger, Shirley Chen
Publikováno v:
Blood. 131:1195-1205
Age-associated changes in hematopoietic stem and progenitor cells (HSPCs) have been carefully documented in mouse models but poorly characterized in primates and humans. To investigate clinically relevant aspects of hematopoietic aging, we compared t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46229a27e8f208bb3ec0677cc94b217d
https://doi.org/10.1182/blood-2017-08-802033
https://doi.org/10.1182/blood-2017-08-802033
Autor:
Rong Lu, Samson J. Koelle, Mario Roederer, E. Lake Potter, Xing Fan, Di Yang, Diego A. Espinoza, Chuanfeng Wu, Brian Li, Cynthia E. Dunbar, Robert E. Donahue
Publikováno v:
The Journal of Experimental Medicine
In this issue of JEM, Wu et al. use genetic barcoding of macaque hematopoietic stem cells to demonstrate that, after transplantation, HSCs are very asymmetrically distributed and uncover a thymus-independent pathway for mature T cell production in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfdbbe67b7533e7c270c4770d7880971
https://doi.org/10.1084/jem.20171341
https://doi.org/10.1084/jem.20171341
Autor:
Chuanfeng Wu, Robert E. Donahue, Samson J. Koelle, Brian Li, Rong Lu, Jason Xu, Cynthia E. Dunbar, Diego A. Espinoza
Publikováno v:
Blood. 129:1448-1457
Autologous transplantation of hematopoietic stem and progenitor cells lentivirally labeled with unique oligonucleotide barcodes flanked by sequencing primer targets enables quantitative assessment of the self-renewal and differentiation patterns of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cda7c52f792740368d9dcbadda99926
https://doi.org/10.1182/blood-2016-07-728691
https://doi.org/10.1182/blood-2016-07-728691
Autor:
Samson J. Koelle, Chuanfeng Wu, Peter Guttorp, Jason Xu, Vladimir N. Minin, Janis L. Abkowitz, Cynthia E. Dunbar
Publikováno v:
Ann. Appl. Stat. 13, no. 4 (2019), 2091-2119
Single-cell lineage tracking strategies enabled by recent experimental technologies have produced significant insights into cell fate decisions, but lack the quantitative framework necessary for rigorous statistical analysis of mechanistic models des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc9d7b7d16098c35bc9f04e2377118e
https://projecteuclid.org/euclid.aoas/1574910037
https://projecteuclid.org/euclid.aoas/1574910037
Autor:
Jan K Davidson-Moncada, Amitinder Kaur, Chuanfeng Wu, Yenan T. Bryceson, Robert E. Donahue, Samson J. Koelle, Rong Lu, Chiara Romagnani, Cynthia E. Dunbar, Heinrich Schlums, David A. Allan, Diego A. Espinoza, Di Yang, Richard W. Childs, Bernard A. P. Lafont, Quirin Hammer, Sandhya R. Panch, Brian Li, Lauren L. Truitt
Publikováno v:
Sci Immunol
Natural killer (NK) cells recognize and eliminate infected and malignant cells. Their life histories are poorly understood, particularly in humans, due to lack of informative models and endogenous clonal markers. Here we apply transplantation of barc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e56c823fa506fe9e581ef6cefd4aa6d
https://doi.org/10.1126/sciimmunol.aat9781
https://doi.org/10.1126/sciimmunol.aat9781
Autor:
Samson J. Koelle, Irvin S. Y. Chen, Rong Lu, Alan E. Krouse, Mark E. Metzger, Karin Loré, Robert E. Donahue, Brian Li, Cynthia E. Dunbar, Irving L. Weissman, Alexander Jares, Frank Liang, Yanqin Yang, Colin O. Wu, Chuanfeng Wu
Publikováno v:
Cell stem cell, vol 14, iss 4
SummaryAnalysis of hematopoietic stem cell function in nonhuman primates provides insights that are relevant for human biology and therapeutic strategies. In this study, we applied quantitative genetic barcoding to track the clonal output of transpla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452f41be9a7dbb0b934c6346ecfa3498
https://europepmc.org/articles/PMC3979461/
https://europepmc.org/articles/PMC3979461/