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pro vyhledávání: '"Samson A. Souza"'
Autor:
Brendan Drouhard, Ho Leung Ng, Abby Held, Michelle Hu, Bryant Avila, Wenjie Lu, Bill R. Miller, Raul Leyva-Montes, Samson A. Souza
Publikováno v:
RSC Chemical Biology
Aromatase (CYP19) catalyzes the last biosynthetic step of estrogens in mammals and is a primary drug target for hormone-related breast cancer. However, treatment with aromatase inhibitors is often associated with adverse effects and drug resistance.
G Protein–Coupled Estrogen Receptor Production Using an Escherichia coli Cell‐Free Expression System
Publikováno v:
Current Protocols in Protein Science. 97
Heterologous expression of the G protein-coupled estrogen receptor (GPER) comes with a suite of challenges intrinsic to membrane proteins. This receptor's low expression levels and tendency to form insoluble aggregates in Escherichia coli and yeast m