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Akademický článek

In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders.

Autor: Grupe M; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark. Electronic address: mogl@lundbeck.com., Bentzen BH; Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen, Denmark., Benned-Jensen T; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Nielsen V; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Frederiksen K; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Jensen HS; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Jacobsen AM; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Skibsbye L; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Sams AG; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Grunnet M; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Rottländer M; CMC Outsourcing, Novo Nordisk A/S, Smoermosevej 17-19, 2880 Bagsvaerd, Denmark., Bastlund JF; H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark.

Publikováno v: European journal of pharmacology [Eur J Pharmacol] 2020 Nov 15; Vol. 887, pp. 173440. Date of Electronic Publication: 2020 Aug 01.

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Akademický článek

Discovery and optimization of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration.

Autor: Eskildsen J; Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark. Electronic address: JORE@lundbeck.com., Redrobe JP; Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Sams AG; Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Dekermendjian K; Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Laursen M; Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Boll JB; Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Papke RL; Department of Pharmacology, University of Florida College of Medicine, Gainesville, FL, USA., Bundgaard C; Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Frederiksen K; Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark., Bastlund JF; Neuroscience Research DK, H. Lundbeck A/S, Ottiliavej 9, 2500 Valby, Denmark.

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2014 Jan 01; Vol. 24 (1), pp. 288-93. Date of Electronic Publication: 2013 Nov 20.

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Akademický článek

Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential.

Autor: Sams AG; Neuroscience Drug Discovery Denmark, H. Lundbeck A/S, Copenhagen-Valby, Denmark. anette.sams@leo-pharma.com, Larsen K, Mikkelsen GK, Hentzer M, Christoffersen CT, Jensen KG, Frederiksen K, Bang-Andersen B

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Aug 01; Vol. 22 (15), pp. 5134-40. Date of Electronic Publication: 2012 May 18.

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Akademický článek

The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade.

Autor: Collins LE; Dept. of Psychology, University of Connecticut, Storrs, CT 06269-1020, USA., Sager TN, Sams AG, Pennarola A, Port RG, Shahriari M, Salamone JD

Publikováno v: Pharmacology, biochemistry, and behavior [Pharmacol Biochem Behav] 2012 Jan; Vol. 100 (3), pp. 498-505. Date of Electronic Publication: 2011 Oct 20.

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Akademický článek

Efficacy switching SAR of mGluR5 allosteric modulators: highly potent positive and negative modulators from one chemotype.

Autor: Sams AG; Discovery Chemistry and DMPK, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark., Mikkelsen GK, Brodbeck RM, Pu X, Ritzén A

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Jun 01; Vol. 21 (11), pp. 3407-10. Date of Electronic Publication: 2011 Apr 05.

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Akademický článek

Discovery of phosphoric acid mono-{2-[(E/Z)-4-(3,3-dimethyl-butyrylamino)-3,5-difluoro-benzoylimino]-thiazol-3-ylmethyl} ester (Lu AA47070): a phosphonooxymethylene prodrug of a potent and selective hA(2A) receptor antagonist.

Autor: Sams AG; Medicinal Chemistry Research, Lundbeck Research Denmark, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Copenhagen Valby, Denmark. anette.sams@leo-pharma.com, Mikkelsen GK, Larsen M, Langgård M, Howells ME, Schrøder TJ, Brennum LT, Torup L, Jørgensen EB, Bundgaard C, Kreilgård M, Bang-Andersen B

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2011 Feb 10; Vol. 54 (3), pp. 751-64. Date of Electronic Publication: 2011 Jan 06.

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Akademický článek

Discovery of N-{1-[3-(3-oxo-2,3-dihydrobenzo[1,4]oxazin-4-yl)propyl]piperidin-4-yl}-2-phenylacetamide (Lu AE51090): an allosteric muscarinic M1 receptor agonist with unprecedented selectivity and procognitive potential.

Autor: Sams AG; Medicinal Chemistry Research, Lundbeck Research Denmark, H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark. anette.sams@leo-pharma.com, Hentzer M, Mikkelsen GK, Larsen K, Bundgaard C, Plath N, Christoffersen CT, Bang-Andersen B

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2010 Sep 09; Vol. 53 (17), pp. 6386-97.

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Akademický článek

Hit-to-lead optimization of a series of carboxamides of ethyl 2-amino-4-phenylthiazole-5-carboxylates as novel adenosine A2A receptor antagonists.

Autor: Sams AG; Medicinal Chemistry Research, H. Lundbeck A/S, Valby, Denmark. anette.sams@leo-pharma.com, Mikkelsen GK, Larsen M, Torup L, Brennum LT, Schrøder TJ, Bang-Andersen B

Publikováno v: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Sep 01; Vol. 20 (17), pp. 5241-4. Date of Electronic Publication: 2010 Jul 24.

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