Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sampurna Chakrabarti"'
Publikováno v:
Neurobiology of Pain, Vol 8, Iss , Pp 100051- (2020)
Pain arising from musculoskeletal disorders such as arthritis is one of the leading causes of disability. Whereas the past 20-years has seen an increase in targeted therapies for rheumatoid arthritis (RA), other arthritis conditions, especially osteo
Externí odkaz:
https://doaj.org/article/fd58f78d76e64ef58ec281f821c97668
Autor:
Aurore Latragna, Alba Sabaté San José, Panagiotis Tsimpos, Simon Vermeiren, Roberta Gualdani, Sampurna Chakrabarti, Gerard Callejo, Simon Desiderio, Orr Shomroni, Maren Sitte, Sadia Kricha, Maëlle Luypaert, Benoit Vanhollebeke, Geoffroy Laumet, Gabriela Salinas, Ewan St. John Smith, Laurence Ris, Eric J. Bellefroid
Publikováno v:
Pain. 163:e927-e941
Prdm12 is a conserved epigenetic transcriptional regulator that displays restricted expression in nociceptors of the developing peripheral nervous system. In mice, Prdm12 is required for the development of the entire nociceptive lineage. In humans, P
Autor:
Oscar Sánchez Carranza, Sampurna Chakrabarti, Johannes Kühnemund, Fred Schwaller, Valérie Bégay, Gary R. Lewin
PIEZO2 mechanosensitive channels are required for normal touch sensation. However, PIEZO2 channels are almost completely blocked at negative resting membrane potentials. We show that PIEZO2 voltage-block can be relieved by mutations at a conserved Ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::290744275402d2613586288ac517b973
https://doi.org/10.1101/2022.10.04.510762
https://doi.org/10.1101/2022.10.04.510762
Autor:
Sampurna Chakrabarti, Minji Ai, Wai Ying Katherine Wong, Frances Henson, Ewan St. John Smith, Karin Newell
Publikováno v:
eNeuro
Knee joint trauma can cause an osteochondral defect (OD), a risk factor for osteoarthritis and cause of debilitating pain in patients. Rodent OD models are less translatable due to their smaller joint size and open growth plate. This study proposes s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d7094af547178f6896754968c62a82
http://edoc.mdc-berlin.de/21010/7/21010suppl.tif
http://edoc.mdc-berlin.de/21010/7/21010suppl.tif
Autor:
Zhen Du, Yavuz Kulaberoglu, Laura S. Itzhaki, Christopher M. Dobson, Ewan St. John Smith, Sampurna Chakrabarti, Janet R. Kumita
Publikováno v:
Biochemical and Biophysical Research Communications
The long-living naked mole-rat (NMR) shows negligible senescence and resistance to age-associated diseases. Recent evidence, based on protein-level assays, suggests that enhanced protein homeostasis machinery contributes to NMR stress-resistance and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dda9bdff854e0eaf02e114030ccd53cd
https://www.repository.cam.ac.uk/handle/1810/307289
https://www.repository.cam.ac.uk/handle/1810/307289
Autor:
Zoe Hore, David C. Bulmer, Ewan St. John Smith, Sylvine Lalnunhlimi, Leonie S. Taams, Charity N. Bhebhe, Franziska Denk, Sampurna Chakrabarti, Luke A. Pattison, Gerard Callejo
Publikováno v:
Pain
Supplemental Digital Content is Available in the Text. Fibroblast-like synoviocytes (FLS) interact with articular sensory nerve endings. Coculture of tumor necrosis factor (TNF-α)-stimulated FLS and knee-innervating sensory neurons reveals FLS-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf08cd7733632e2a8dfd160ca7b0f24a
Autor:
Gerard Callejo, Rebecca H. Rickman, Luke A. Pattison, Helen Blake, Ewan St. John Smith, Balint Doleschall, Sampurna Chakrabarti, Paul A. Heppenstall
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)References. 72(10)
Objective Joint pain is the major clinical symptom of arthritis that affects millions of people. Controlling the excitability of knee-innervating dorsal root ganglion (DRG) neurons (knee neurons) could potentially provide pain relief. We undertook th
Autor:
Sampurna Chakrabarti, Luke A. Pattison, Balint Doleschall, Rebecca H. Rickman, Helen Blake, Gerard Callejo, Paul A. Heppenstall, Ewan St. John Smith
ObjectiveJoint pain is the major clinical symptom of arthritis that affects millions of people. Controlling the excitability of knee-innervating dorsal root ganglion (DRG) neurons (knee neurons) could potentially provide pain relief. Therefore, our o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11a06662720b78775bbb7d9fda547cd
https://doi.org/10.1101/2020.02.08.939066
https://doi.org/10.1101/2020.02.08.939066
Autor:
Zoe Hore, Franziska Denk, Gerard Callejo, Sylvine Lalnunhlimi, Sampurna Chakrabarti, Leonie S. Taams, David C. Bulmer, Luke A. Pattison, Ewan St. John Smith, Charity N. Bhebhe
Background Pain is a principle contributor to the global burden of arthritis with peripheral sensitization being a major cause of arthritis-related pain. Within the knee joint, distal endings of dorsal root ganglion neurons (knee neurons) interact wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b12620839b293043504caef4490899
https://doi.org/10.1101/791251
https://doi.org/10.1101/791251
Publikováno v:
Rheumatology.
Objectives Knee OA is a leading global cause of morbidity. This study investigates the effects of knee SF from patients with OA on the activity of dorsal root ganglion sensory neurons that innervate the knee (knee neurons) as a novel translational mo