Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Sampsa Matikainen"'
Autor:
Martina B. Lorey, Amer Youssef, Lauri Äikäs, Matthew Borrelli, Martin Hermansson, Julia M. Assini, Aapeli Kemppainen, Hanna Ruhanen, Maija Ruuth, Sampsa Matikainen, Petri T. Kovanen, Reijo Käkelä, Michael B. Boffa, Marlys L. Koschinsky, Katariina Öörni
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 10 (2023)
IntroductionLipoprotein(a) (Lp(a)) is an LDL-like particle with an additional apolipoprotein (apo)(a) covalently attached. Elevated levels of circulating Lp(a) are a risk factor for atherosclerosis. A proinflammatory role for Lp(a) has been proposed,
Externí odkaz:
https://doaj.org/article/e718ebe0203e44b68e68438c5b4d9562
Autor:
Katariina Nurmi, Katri Niemi, Ilona Kareinen, Kristiina Silventoinen, Martina B Lorey, Yan Chen, Vesa‐Petteri Kouri, Jukka Parantainen, Timo Juutilainen, Katariina Öörni, Petri T Kovanen, Dan Nordström, Sampsa Matikainen, Kari K Eklund
Publikováno v:
Clinical & Translational Immunology, Vol 10, Iss 8, Pp n/a-n/a (2021)
Abstract Objectives The NLRP3 inflammasome plays a key role in arterial wall inflammation. In this study, we elucidated the role of serum lipoproteins in the regulation of NLRP3 inflammasome activation by serum amyloid A (SAA) and other inflammasome
Externí odkaz:
https://doaj.org/article/758af8f4859648f6b84a88fa15cc16c5
Publikováno v:
Viruses, Vol 13, Iss 12, p 2513 (2021)
SARS-CoV-2 is a new type of coronavirus that has caused worldwide pandemic. The disease induced by SARS-CoV-2 is called COVID-19. A majority of people with COVID-19 have relatively mild respiratory symptoms. However, a small percentage of COVID-19 pa
Externí odkaz:
https://doaj.org/article/9a8e2292898c489195d50fc938b2973c
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Inflammasomes are intracellular protein complexes of pattern recognition receptors and caspase-1, with essential functions in regulating inflammatory responses of macrophages and dendritic cells. The primary role of inflammasomes is to catalyze proce
Externí odkaz:
https://doaj.org/article/b6ae569f5d3a4b0685eda973e546068d
Publikováno v:
Viruses, Vol 1, Iss 3, Pp 737-759 (2009)
Herpes simplex virus (HSV), a human pathogenic virus, has evolved several strategies to evade the production and function of interferons (IFNs) and cytokines generated by the innate immune system to restrict the virus. Equilibrium exists between the
Externí odkaz:
https://doaj.org/article/52cd534c820c436488e0b69f8766a820
Autor:
Daria Bulanova, Aleksandr Ianevski, Andrii Bugai, Yevhen Akimov, Suvi Kuivanen, Henrik Paavilainen, Laura Kakkola, Jatin Nandania, Laura Turunen, Tiina Ohman, Hanna Ala-Hongisto, Hanna M. Pesonen, Marika S. Kuisma, Anni Honkimaa, Emma L. Walton, Valentyn Oksenych, Martina B. Lorey, Dmitry Guschin, Jungmin Shim, Jinhee Kim, Thoa T. Than, So Young Chang, Veijo Hukkanen, Evgeny Kulesskiy, Varpu S. Marjomaki, Ilkka Julkunen, Tuula A. Nyman, Sampsa Matikainen, Jani S. Saarela, Famara Sane, Didier Hober, Gülsah Gabriel, Jef K. De Brabander, Miika Martikainen, Marc P. Windisch, Ji-Young Min, Roberto Bruzzone, Tero Aittokallio, Markus Vähä-Koskela, Olli Vapalahti, Arto Pulk, Vidya Velagapudi, Denis E. Kainov
Publikováno v:
Viruses, Vol 9, Iss 10, p 271 (2017)
Viral diseases remain serious threats to public health because of the shortage of effective means of control. To combat the surge of viral diseases, new treatments are urgently needed. Here we show that small-molecules, which inhibit cellular anti-ap
Externí odkaz:
https://doaj.org/article/a2efcfb6a1b5438e8d4582f4bed8125b
Autor:
Markus Vähä-Koskela, Siri Tähtinen, Susanna Grönberg-Vähä-Koskela, Kristian Taipale, Dipongkor Saha, Maiju Merisalo-Soikkeli, Marko Ahonen, Noora Rouvinen-Lagerström, Mari Hirvinen, Ville Veckman, Sampsa Matikainen, Fang Zhao, Päivi Pakarinen, Jarmo Salo, Anna Kanerva, Vincenzo Cerullo, Akseli Hemminki
Publikováno v:
Molecular Therapy: Oncolytics, Vol 1, Iss C (2014)
Successful cancer control relies on overcoming resistance to cell death and on activation of host antitumor immunity. Oncolytic viruses are particularly attractive in this regard, as they lyse infected tumor cells and trigger robust immune responses
Externí odkaz:
https://doaj.org/article/9b01b1c35c2c4311bda6e7bc3f0a87b4
Autor:
Sandra Söderholm, Yu Fu, Lana Gaelings, Sergey Belanov, Laxman Yetukuri, Mikhail Berlinkov, Anton V. Cheltsov, Simon Anders, Tero Aittokallio, Tuula A. Nyman, Sampsa Matikainen, Denis E. Kainov
Publikováno v:
Viruses, Vol 8, Iss 10, p 269 (2016)
Human influenza A viruses (IAVs) cause global pandemics and epidemics. These viruses evolve rapidly, making current treatment options ineffective. To identify novel modulators of IAV–host interactions, we re-analyzed our recent transcriptomics, met
Externí odkaz:
https://doaj.org/article/4643799c8aa444e596e0e2e1cf80eccc
Autor:
Vilma Aho, Hanna M Ollila, Ville Rantanen, Erkki Kronholm, Ida Surakka, Wessel M A van Leeuwen, Maili Lehto, Sampsa Matikainen, Samuli Ripatti, Mikko Härmä, Mikael Sallinen, Veikko Salomaa, Matti Jauhiainen, Harri Alenius, Tiina Paunio, Tarja Porkka-Heiskanen
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77184 (2013)
Epidemiological studies have shown that short or insufficient sleep is associated with increased risk for metabolic diseases and mortality. To elucidate mechanisms behind this connection, we aimed to identify genes and pathways affected by experiment
Externí odkaz:
https://doaj.org/article/625d9771d6214b2a8ee224d4b019e562
Autor:
Randi K Berg, Jesper Melchjorsen, Johanna Rintahaka, Elisabeth Diget, Stine Søby, Kristy A Horan, Robert J Gorelick, Sampsa Matikainen, Carsten S Larsen, Lars Ostergaard, Søren R Paludan, Trine H Mogensen
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29291 (2012)
Innate immune responses have recently been appreciated to play an important role in the pathogenesis of HIV infection. Whereas inadequate innate immune sensing of HIV during acute infection may contribute to failure to control and eradicate infection
Externí odkaz:
https://doaj.org/article/d8c736f6b6944260bc7eb870be830708