Gut Pathobiont-Derived Outer Membrane Vesicles Drive Liver Inflammation and Fibrosis in Primary Sclerosing Cholangitis-Associated Inflammatory Bowel Disease.

Autor: Dorner H; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Stolzer I; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Mattner J; Institute of Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Friedrich-Alexander-Universität Erlangen-Nürnberg Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Kaminski S; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Leistl S; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Edrich LM; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Schwendner R; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Hobauer J; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Sebald A; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Leikam S; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Gonzalez Acera M; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Düll M; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Lang R; Institute of Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Friedrich-Alexander-Universität Erlangen-Nürnberg Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Seidel G; Microbiology, Department of Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Seitz T; Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Hellerbrand C; Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Fuhrmann G; Department of Biology, Pharmaceutical Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Distler U; Institute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany., Tenzer S; Institute of Immunology, University Medical Center of the Johannes-Gutenberg University, Mainz, Germany., Eichhorn P; Institute of Pathology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Vieth M; Institute of Pathology, Klinikum Bayreuth, Friedrich-Alexander-Universität Erlangen-Nürnberg, Bayreuth, Germany., Schramm C; Department of Medicine, Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Arnold P; Institute of Functional and Clinical Anatomy, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Becker C; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Friedrich-Alexander-Universität Erlangen-Nürnberg Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Deutsches Zentrum Immuntherapie, Universitätsklinikum Erlangen, Erlangen, Germany., Weidinger C; Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Siegmund B; Division of Gastroenterology, Infectiology and Rheumatology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Atreya R; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Friedrich-Alexander-Universität Erlangen-Nürnberg Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Deutsches Zentrum Immuntherapie, Universitätsklinikum Erlangen, Erlangen, Germany., Leppkes M; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Deutsches Zentrum Immuntherapie, Universitätsklinikum Erlangen, Erlangen, Germany., Naschberger E; Division of Molecular and Experimental Surgery, Department of Surgery, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Sampaziotis F; Wellcome-Medical Research Council Cambridge Stem Cell Institute, Cambridge, United Kingdom; Cambridge Liver Unit, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Dietrich P; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Institute of Biochemistry, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Rauh M; Research Laboratory, Division of Pediatrics, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Wirtz S; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Friedrich-Alexander-Universität Erlangen-Nürnberg Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Deutsches Zentrum Immuntherapie, Universitätsklinikum Erlangen, Erlangen, Germany., Kremer AE; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Deutsches Zentrum Immuntherapie, Universitätsklinikum Erlangen, Erlangen, Germany; Department of Gastroenterology and Hepatology, University Hospital Zürich, University of Zürich, Zürich, Switzerland., Neurath MF; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Friedrich-Alexander-Universität Erlangen-Nürnberg Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Deutsches Zentrum Immuntherapie, Universitätsklinikum Erlangen, Erlangen, Germany., Günther C; Department of Medicine 1, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Friedrich-Alexander-Universität Erlangen-Nürnberg Profile Center Immunomedicine, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany; Deutsches Zentrum Immuntherapie, Universitätsklinikum Erlangen, Erlangen, Germany. Electronic address: c.guenther@uk-erlangen.de.

Publikováno v: Gastroenterology [Gastroenterology] 2024 Nov; Vol. 167 (6), pp. 1183-1197.e16. Date of Electronic Publication: 2024 Jul 09.

Time will tell: Employing long-term normothermic machine perfusion to gain new insight into bile duct regeneration.

Autor: Brevini T; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK., Sampaziotis F; Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; National Institute of Health Research (NIHR) Blood and Transplant Research Unit (BTRU) at the University of Cambridge in collaboration with Newcastle University and in partnership with NHS Blood and Transplant (NHSBT), Cambridge, UK; Centre for Translational Stem Cell Biology, Hong Kong. Electronic address: fs347@cam.ac.uk.

Publikováno v: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [Am J Transplant] 2024 Sep 24. Date of Electronic Publication: 2024 Sep 24.

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.

Autor: Brevini T; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. tb647@cam.ac.uk., Maes M; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Webb GJ; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., John BV; Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA., Fuchs CD; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Buescher G; Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Wang L; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Griffiths C; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Brown ML; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Scott WE 3rd; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Pereyra-Gerber P; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Gelson WTH; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Brown S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Dillon S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Muraro D; Wellcome Sanger Institute, Hinxton, UK., Sharp J; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Neary M; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Box H; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Tatham L; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Stewart J; Department of Infection Biology and Microbiomes, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK., Curley P; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Pertinez H; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Forrest S; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Mlcochova P; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA., Varankar SS; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Darvish-Damavandi M; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Mulcahy VL; Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK., Kuc RE; Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Williams TL; Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Heslop JA; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Rossetti D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Tysoe OC; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Galanakis V; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Vila-Gonzalez M; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Crozier TWM; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Bargehr J; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Sinha S; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Division of Cardiovascular Medicine, University of Cambridge, Cambridge, UK., Upponi SS; Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Fear C; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Swift L; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Davies SE; Department of Histopathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Wester A; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden., Hagström H; Department of Medicine, Huddinge, Karolinska Institutet, Stockholm, Sweden., Melum E; Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.; Section of Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo University Hospital, Rikshospitalet, Oslo, Norway.; Hybrid Technology Hub Centre of Excellence, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway., Clements D; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Humphreys P; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK., Herriott J; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Kijak E; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Cox H; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Bramwell C; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Valentijn A; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Illingworth CJR; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.; Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK., Dahman B; Department of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA., Bastaich DR; Department of Health Behavior and Policy, Virginia Commonwealth University, Richmond, VA, USA., Ferreira RD; Division of Gastroenterology and Hepatology, University of Miami and Miami VA Health System, Miami, FL, USA., Marjot T; Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK., Barnes E; Oxford Liver Unit, Translational Gastroenterology Unit, Oxford University Hospitals NHS Foundation Trust, University of Oxford, Oxford, UK., Moon AM; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA., Barritt AS 4th; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA., Gupta RK; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK., Baker S; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Davenport AP; Experimental Medicine and Immunotherapeutics, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK., Corbett G; Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Gorgoulis VG; Department of Histology and Embryology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.; Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.; Biomedical Research Foundation, Academy of Athens, Athens, Greece., Buczacki SJA; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK., Lee JH; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Matheson NJ; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK.; Department of Medicine, University of Cambridge, Cambridge, UK.; Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, NC, USA.; NHS Blood and Transplant, Cambridge, UK., Trauner M; Hans Popper Laboratory of Molecular Hepatology, Division of Gastroenterology and Hepatology, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria., Fisher AJ; Transplant and Regenerative Medicine Laboratory, Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Gibbs P; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Butler AJ; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Watson CJE; Department of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.; Roy Calne Transplant Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; National Institute of Health Research (NIHR) Cambridge Biomedical Research Centre, and the NIHR Blood and Transplant Research Unit (BTRU) at the University of Cambridge in collaboration with Newcastle University and in partnership with NHS Blood and Transplant (NHSBT), Cambridge, UK., Mells GF; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.; Academic Department of Medical Genetics, University of Cambridge, Cambridge, UK., Dougan G; Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, University of Cambridge, Cambridge, UK., Owen A; Centre of Excellence in Long-acting Therapeutics (CELT), Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK., Lohse AW; Department of Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Vallier L; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. ludovic.vallier@bih-charite.de.; Wellcome Sanger Institute, Hinxton, UK. ludovic.vallier@bih-charite.de.; Berlin Institute of Health (BIH), BIH Centre for Regenerative Therapies (BCRT), Charité-Universitätsmedizin Berlin, Berlin, Germany. ludovic.vallier@bih-charite.de.; Max Planck Institute for Molecular Genetics, Berlin, Germany. ludovic.vallier@bih-charite.de., Sampaziotis F; Wellcome-MRC Cambridge Stem Cell Institute, Cambridge, UK. fs347@cam.ac.uk.; Cambridge Liver Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK. fs347@cam.ac.uk.; Department of Medicine, University of Cambridge, Cambridge, UK. fs347@cam.ac.uk.

Publikováno v: Nature [Nature] 2023 Mar; Vol. 615 (7950), pp. 134-142. Date of Electronic Publication: 2022 Dec 05.

Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts tropism and fusogenicity

Autor: Meng, B., Abdullahi, A., Ferreira, I., Goonawardane, N., Saito, A., Kimura, I., Yamasoba, D., Gerber, P., Fatihi, S., Rathore, S., Zepeda, S., Papa, G., Kemp, S., Ikeda, T., Toyoda, M., Tan, T., Kuramochi, J., Mitsunaga, S., Ueno, T., Shirakawa, K., Takaori-Kondo, A., Brevini, T., Mallery, D., Charles, O., Collaboration, C., Japan, G., Consortium, E., Bowen, J., Joshi, A., Walls, A., Jackson, L., Martin, D., Smith, K., Bradley, J., Briggs, J., Choi, J., Madissoon, E., Meyer, K., Mlcochova, P., Ceron-Gutierrez, L., Doffinger, R., Teichmann, S., Fisher, A., Pizzuto, M., de Marco, A., Corti, D., Hosmillo, M., Lee, J., James, L., Thukral, L., Veesler, D., Sigal, A., Sampaziotis, F., Goodfellow, I., Matheson, N., Sato, K., Gupta, R.

Publikováno v: Nature

The SARS-CoV-2 Omicron BA.1 variant emerged in 20211 and bears multiple spike mutations2. Here we show that Omicron spike has higher affinity for ACE2 compared to Delta as well as a marked change of antigenicity conferring significant evasion of ther

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::66e41b100793b79b637db48a99a5038c
http://hdl.handle.net/2433/275415

Single-cell atlas of human liver development reveals pathways directing hepatic cell fates.

Autor: Wesley BT; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Ross ADB; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Muraro D; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK.; Wellcome Sanger Institute, Hinxton, UK., Miao Z; Wellcome Sanger Institute, Hinxton, UK.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, UK., Saxton S; Departments of Bioengineering and Pathology, University of Washington, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Tomaz RA; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Morell CM; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Ridley K; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Zacharis ED; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Petrus-Reurer S; Department of Surgery, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Kraiczy J; Department of Paediatrics, University of Cambridge, Cambridge, UK., Mahbubani KT; Department of Surgery, University of Cambridge, Cambridge, UK., Brown S; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Garcia-Bernardo J; Wellcome Sanger Institute, Hinxton, UK., Alsinet C; Wellcome Sanger Institute, Hinxton, UK., Gaffney D; Wellcome Sanger Institute, Hinxton, UK., Horsfall D; Digital Institute, Newcastle University, Newcastle upon Tyne, UK., Tysoe OC; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Botting RA; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Stephenson E; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., Popescu DM; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK., MacParland S; University of Toronto, Toronto, Ontario, Canada., Bader G; University of Toronto, Toronto, Ontario, Canada., McGilvray ID; Multi-Organ Transplant Program, Toronto General Hospital Research Institute, Toronto, Ontario, Canada., Ortmann D; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Sampaziotis F; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Surgery, University of Cambridge, Cambridge, UK., Saeb-Parsy K; Department of Surgery, University of Cambridge, Cambridge, UK.; NIHR Cambridge Biomedical Research Centre, Cambridge, UK., Haniffa M; Wellcome Sanger Institute, Hinxton, UK.; Biosciences Institute, Newcastle University, Newcastle upon Tyne, UK.; Department of Dermatology and NIHR Newcastle Biomedical Research Centre, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Stevens KR; Departments of Bioengineering and Pathology, University of Washington, Seattle, WA, USA.; Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA., Zilbauer M; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.; Department of Paediatrics, University of Cambridge, Cambridge, UK., Teichmann SA; Wellcome Sanger Institute, Hinxton, UK.; Theory of Condensed Matter Group, Cavendish Laboratory, University of Cambridge, Cambridge, UK., Vallier L; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK. lv225@cam.ac.uk.; Department of Surgery, University of Cambridge, Cambridge, UK. lv225@cam.ac.uk.

Publikováno v: Nature cell biology [Nat Cell Biol] 2022 Oct; Vol. 24 (10), pp. 1487-1498. Date of Electronic Publication: 2022 Sep 15.