Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Sampath K. Loganathan"'
Autor:
Dzana Dervovic, Ahmad A. Malik, Edward L. Y. Chen, Masahiro Narimatsu, Nina Adler, Somaieh Afiuni-Zadeh, Dagmar Krenbek, Sebastien Martinez, Ricky Tsai, Jonathan Boucher, Jacob M. Berman, Katie Teng, Arshad Ayyaz, YiQing Lü, Geraldine Mbamalu, Sampath K. Loganathan, Jongbok Lee, Li Zhang, Cynthia Guidos, Jeffrey Wrana, Arschang Valipour, Philippe P. Roux, Jüri Reimand, Hartland W. Jackson, Daniel Schramek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract How the genetic landscape governs a tumor’s response to immunotherapy remains poorly understood. To assess the immune-modulatory capabilities of 573 genes associated with altered cytotoxicity in human cancers, here we perform CRISPR/Cas9 s
Externí odkaz:
https://doaj.org/article/e4b4d4a5470d43e0817e0d24ed7429c7
Autor:
Dzana Dervovic, Ahmad A. Malik, Edward L. Y. Chen, Masahiro Narimatsu, Nina Adler, Somaieh Afiuni-Zadeh, Dagmar Krenbek, Sebastien Martinez, Ricky Tsai, Jonathan Boucher, Jacob M. Berman, Katie Teng, Arshad Ayyaz, YiQing Lü, Geraldine Mbamalu, Sampath K. Loganathan, Jongbok Lee, Li Zhang, Cynthia Guidos, Jeffrey Wrana, Arschang Valipour, Philippe P. Roux, Jüri Reimand, Hartland W. Jackson, Daniel Schramek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/2c37d159f9ad4586ac8c4e1cbb1c41af
Autor:
Ana Vujovic, Laura de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian A. Yee, Sampath K. Loganathan, Lina Liu, Derek C.H. Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Zaldy Balde, Soheil Jahangiri, Sasan Zandi, Stefan Aigner, John E. Dick, Mark D. Minden, Daniel Schramek, Gene W. Yeo, Kristin J. Hope
Publikováno v:
Blood Cancer Discovery. 4:180-207
Acute myeloid leukemia (AML) is fueled by leukemic stem cells (LSC) whose determinants are challenging to discern from hematopoietic stem cells (HSC) or uncover by approaches focused on general cell properties. We have identified a set of RNA-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55d13c8425215d000309cd12391bf1f8
https://doi.org/10.1158/2643-3230.bcd-22-0086
https://doi.org/10.1158/2643-3230.bcd-22-0086
Autor:
Kristin J. Hope, Gene W. Yeo, Daniel Schramek, Mark D. Minden, John E. Dick, Stefan Aigner, Sasan Zandi, Soheil Jahangiri, Zaldy Balde, Nicholas Wong, Joshua Xu, Pratik Joshi, Steven Moreira, Emily Tsao, Amanda Tajik, Derek C.H. Chan, Lina Liu, Sampath K. Loganathan, Brian A. Yee, He Tian Chen, Ava Keyvani Chahi, Laura de Rooij, Ana Vujovic
Table S5 shows the log2 fold change of differentially expressed transcripts from the ELAVL1 knockout RN2c RNA-sequencing data set.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238801bda66a9156f6af773fa36da1b5
https://doi.org/10.1158/2643-3230.22725570
https://doi.org/10.1158/2643-3230.22725570
Autor:
Kristin J. Hope, Gene W. Yeo, Daniel Schramek, Mark D. Minden, John E. Dick, Stefan Aigner, Sasan Zandi, Soheil Jahangiri, Zaldy Balde, Nicholas Wong, Joshua Xu, Pratik Joshi, Steven Moreira, Emily Tsao, Amanda Tajik, Derek C.H. Chan, Lina Liu, Sampath K. Loganathan, Brian A. Yee, He Tian Chen, Ava Keyvani Chahi, Laura de Rooij, Ana Vujovic
Supplemental Figure S4 shows the validation of ELAVL1 knockdown by western blot and effects of ELAVL1 loss on human primary AML cells in vitro and in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75cb536bc316f972180d6869ba2df29c
https://doi.org/10.1158/2643-3230.22725594
https://doi.org/10.1158/2643-3230.22725594
Autor:
Kristin J. Hope, Gene W. Yeo, Daniel Schramek, Mark D. Minden, John E. Dick, Stefan Aigner, Sasan Zandi, Soheil Jahangiri, Zaldy Balde, Nicholas Wong, Joshua Xu, Pratik Joshi, Steven Moreira, Emily Tsao, Amanda Tajik, Derek C.H. Chan, Lina Liu, Sampath K. Loganathan, Brian A. Yee, He Tian Chen, Ava Keyvani Chahi, Laura de Rooij, Ana Vujovic
Acute myeloid leukemia (AML) is fueled by leukemic stem cells (LSC) whose determinants are challenging to discern from hematopoietic stem cells (HSC) or uncover by approaches focused on general cell properties. We have identified a set of RNA-binding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c408b73a88713bd19863989035bb281
https://doi.org/10.1158/2643-3230.c.6572000
https://doi.org/10.1158/2643-3230.c.6572000
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Systematically investigating the scores of genes mutated in cancer and discerning disease drivers from inconsequential bystanders is a prerequisite for precision medicine but remains challenging. Here, we developed a somatic CRISPR/Cas9 mutagenesis s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3e88720028d1c1acd19d4e081944a9
https://doi.org/10.1158/2159-8290.c.6549708.v1
https://doi.org/10.1158/2159-8290.c.6549708.v1
Autor:
Daniel Schramek, Geoffrey M. Wahl, Miguel Angel Pujana, Erik S. Knudsen, Agnieszka K. Witkiewicz, Michael D. Wilson, Hartland W. Jackson, Jeffrey L. Wrana, Therese Sørlie, David W. Cescon, Sean E. Egan, Gary D. Bader, Rod Bremner, Sampath K. Loganathan, Seda Barutcu, Thomas Nguyen, Jeff C. Liu, Masahiro Narimatsu, Daniel Trcka, Katelyn J. Kozma, Robin H. Oh, YiQing Lü, Andrew Elia, Sana Alvi, Ricky Tsai, Somaieh Afiuni-Zadeh, Samah El Ghamrasni, Helga Bergholtz, Ahmad Malik, Katie Teng, Roderic Espin, Liis Uuskula-Reimand, Minggao Liang, Zhibo Ma, Khalid N. Al-Zahrani, Ellen Langille
Supplementary Data from Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0b4da81cbb00416f796f44e9fdd2b9
https://doi.org/10.1158/2159-8290.22541622.v1
https://doi.org/10.1158/2159-8290.22541622.v1
Autor:
Ana Vujovic, Laura P.M.H. de Rooij, Ava Keyvani Chahi, He Tian Chen, Brian Yee, Sampath K Loganathan, Lina Liu, Derek C.H. Chan, Amanda Tajik, Emily Tsao, Steven Moreira, Pratik Joshi, Joshua Xu, Nicholas Wong, Sasan Zandi, Stefan Aigner, John E. Dick, Mark D. Minden, Daniel Schramek, Gene W. Yeo, Kristin J. Hope
SUMMARYAcute myeloid leukemia (AML) progression and relapse is fueled by self-renewing leukemic stem cells (LSCs) whose molecular determinants have been difficult to discern from normal hematopoietic stem cells (HSCs) or to uncover in screening appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::661491ba6391e52016995ed0d18dbb29
https://doi.org/10.1101/2022.06.11.494613
https://doi.org/10.1101/2022.06.11.494613
Autor:
Nicole L. Michmerhuizen, Caitlin Heenan, Jiayu Wang, Elizabeth Leonard, Emily Bellile, Sampath K. Loganathan, Sunny Y. Wong, Yu L. Lei, J. Chad Brenner
Publikováno v:
Oral oncology. 126
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae35cf6d022af553edfe763b1b4bfc18
https://pubmed.ncbi.nlm.nih.gov/35172244
https://pubmed.ncbi.nlm.nih.gov/35172244