Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sampada B. Upadhye"'
Autor:
Sampada B. Upadhye, Ron S. Vladyka, Xingyou Ye, Hemlata Patil, Venkata Raman Kallakunta, Roshan V. Tiwari, Dong Wuk Kim, Michael A. Repka
Publikováno v:
J Pharm Sci
Dry granulation is an indispensable process used to improve the flow property of moisture-sensitive materials. Considering the limitations of currently available dry granulation techniques, it is necessary to develop a novel technique. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbe83aa4146183dd160013e572f88295
https://europepmc.org/articles/PMC6708445/
https://europepmc.org/articles/PMC6708445/
Autor:
Xingyou Ye, Roshan V. Tiwari, Michael A. Repka, Sandeep Sarabu, Suresh Bandari, Ronald S. Vladyka, Dong Wuk Kim, Venkata Raman Kallakunta, Hemlata Patil, Sampada B. Upadhye
Publikováno v:
International journal of pharmaceutics. 555
Dry granulation is the preferred technique for solvent-sensitive products, especially drugs with stability problems such as hydrolysis. Twin-screw granulation is a continuous granulation technique, offering a potential alternative to conventional dry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e83f747e398547002d8c0946bc55c8
https://pubmed.ncbi.nlm.nih.gov/30458256
https://pubmed.ncbi.nlm.nih.gov/30458256
Publikováno v:
International Journal of Pharmaceutics. 496:33-41
The objective of the present study was to develop pH-independent/dependent sustained release (SR) tablets of ondansetron HCl dihydrate (OND), a selective 5-HT3 receptor antagonist that is used for prevention of nausea and vomiting caused by chemother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e02bb2c9c4d859bd100462af9a32377e
https://doi.org/10.1016/j.ijpharm.2015.04.009
https://doi.org/10.1016/j.ijpharm.2015.04.009
Autor:
Sunil Kumar Battu, Soumyajit Majumdar, Sampada B. Upadhye, Michael A. Repka, Ramesh Srirangam
Publikováno v:
Expert Opinion on Drug Delivery. 5:1357-1376
In today’s pharmaceutical arena, it is estimated that more than 40% of new chemical entities produced during drug discovery efforts exhibit poor solubility characteristics. However, over the last decade hot-melt extrusion (HME) has emerged as a pow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d559512d70c448c0455dbff5ce41f97b
https://doi.org/10.1517/17425240802583421
https://doi.org/10.1517/17425240802583421
Autor:
Michael A. Repka, Michael M. Crowley, Charles R. Martin, Sridhar Thumma, Sampada B. Upadhye, James W. McGinity, Feng Zhang, Sunil Kumar Battu
Publikováno v:
Drug Development and Industrial Pharmacy. 33:909-926
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years. Hot-melt extrusion (HME) has been a widely applied tech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b77de3c114e62cc1fd1b02d08b93b77
https://doi.org/10.1080/03639040701498759
https://doi.org/10.1080/03639040701498759
Autor:
Michael A, Repka, Sunil Kumar, Battu, Sampada B, Upadhye, Sridhar, Thumma, Michael M, Crowley, Feng, Zhang, Charles, Martin, James W, McGinity
Publikováno v:
Drug Development and Industrial Pharmacy. 33:1043-1057
The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various appro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c7c901681bf3c06b32041ef54b278c
https://doi.org/10.1080/03639040701525627
https://doi.org/10.1080/03639040701525627
Publikováno v:
Excipient Applications in Formulation Design and Drug Delivery ISBN: 9783319202051
Moisture sensitivity of active pharmaceutical ingredients (APIs) presents a formidable challenge in the formulation of oral dosage forms. The interaction of moisture with APIs is crucial to an understanding of water-based processes, e.g. manufacturin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15b45d341acf61b073e8ce56a528a398
https://doi.org/10.1007/978-3-319-20206-8_13
https://doi.org/10.1007/978-3-319-20206-8_13
Preparation of amorphous solid dispersions using polymers is a commonly used formulation strategy for enhancing the solubility of poorly water-soluble drugs. However, often a single polymer may not bring about a significant enhancement in solubility
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12b0feb270a33bd12185895d78579c8
https://europepmc.org/articles/PMC4070256/
https://europepmc.org/articles/PMC4070256/
Publikováno v:
AAPS Advances in the Pharmaceutical Sciences Series ISBN: 9781461484318
Polyethylene oxide, by virtue of its thermoplastic behavior, may be a suitable polymer for pharmaceutical dosage form using hot-melt extrusion technology. Applications of high molecular weight POLYOX allows formulation of extended-release melt-extrud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::139ada152b59d6b243ab27572cebf0e9
https://doi.org/10.1007/978-1-4614-8432-5_6
https://doi.org/10.1007/978-1-4614-8432-5_6
Autor:
Swapnil J. Kulkarni, Mahmoud A. ElSohly, Waseem Gul, Michael A. Repka, Mitchell A. Avery, Soumyajit Majumdar, Sampada B. Upadhye
Delta(9)-Tetrahydrocannabinol hemisuccinate (THC-HS), an ester prodrug of Delta(9)-tetrahydrocannabinol (THC) has been investigated for its potential to form inclusion complexes with modified synthetic beta-cyclodextrins (CDs). Phase solubility studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aea24e09bb41d35989a5d83e7d69390
https://europepmc.org/articles/PMC2902337/
https://europepmc.org/articles/PMC2902337/