PHLDA2-mediated phosphatidic acid peroxidation triggers a distinct ferroptotic response during tumor suppression.

Autor: Yang X; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Wang Z; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Samovich SN; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA., Kapralov AA; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Amoscato AA; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Tyurin VA; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Dar HH; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Li Z; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Duan S; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Kon N; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Chen D; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Tycko B; Hackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ 07110, USA., Zhang Z; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA; Department of Pediatrics and Department of Genetics and Development, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA., Jiang X; Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA., Bayir H; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA; Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh, Pittsburgh, PA 15224, USA., Stockwell BR; Department of Chemistry, Columbia University, New York, NY 10027, USA; Department of Biological Sciences, Columbia University, New York, NY 10027, USA., Kagan VE; Center for Free Radical and Antioxidant Health and Departments of Environmental Health, Chemistry, Pharmacology and Chemical Biology, Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15261, USA., Gu W; Institute for Cancer Genetics and Herbert Irving Comprehensive Cancer Center, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Vagelos College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA. Electronic address: wg8@cumc.columbia.edu.

Publikováno v: Cell metabolism [Cell Metab] 2024 Apr 02; Vol. 36 (4), pp. 762-777.e9. Date of Electronic Publication: 2024 Feb 02.

Anomalous peroxidase activity of cytochrome c is the primary pathogenic target in Barth syndrome.

Autor: Kagan VE; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, School of Public Health, Children's Neuroscience Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. kagan@pitt.edu., Tyurina YY; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, School of Public Health, Children's Neuroscience Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Mikulska-Ruminska K; Institute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, Toruń, Poland., Damschroder D; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA., Vieira Neto E; Department of Pediatrics, Genetic and Genomic Medicine Division, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA., Lasorsa A; Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands., Kapralov AA; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, School of Public Health, Children's Neuroscience Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Tyurin VA; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, School of Public Health, Children's Neuroscience Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Amoscato AA; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, School of Public Health, Children's Neuroscience Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Samovich SN; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, School of Public Health, Children's Neuroscience Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Souryavong AB; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, School of Public Health, Children's Neuroscience Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Dar HH; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, School of Public Health, Children's Neuroscience Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Ramim A; Department of Biological Sciences, Wayne State University, Detroit, MI, USA., Liang Z; Department of Biological Sciences, Wayne State University, Detroit, MI, USA., Lazcano P; Department of Biological Sciences, Wayne State University, Detroit, MI, USA., Ji J; Department of Biological Sciences, Wayne State University, Detroit, MI, USA., Schmidtke MW; Department of Biological Sciences, Wayne State University, Detroit, MI, USA., Kiselyov K; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA., Korkmaz A; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA., Vladimirov GK; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, School of Public Health, Children's Neuroscience Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Artyukhova MA; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, School of Public Health, Children's Neuroscience Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Rampratap P; Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands., Cole LK; Department of Pharmacology and Therapeutics, University of Manitoba, Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada., Niyatie A; Department of Pediatrics, Pediatric Institute for Heart Regeneration and Therapeutics, University of Pittsburgh, Pittsburgh, PA, USA., Baker EK; Department of Chemistry & Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada., Peterson J; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, School of Public Health, Children's Neuroscience Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Hatch GM; Department of Pharmacology and Therapeutics, University of Manitoba, Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada., Atkinson J; Department of Chemistry & Centre for Biotechnology, Brock University, St Catharines, Ontario, Canada., Vockley J; Department of Pediatrics, Genetic and Genomic Medicine Division, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA., Kühn B; Department of Pediatrics, Pediatric Institute for Heart Regeneration and Therapeutics, University of Pittsburgh, Pittsburgh, PA, USA., Wessells R; Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA., van der Wel PCA; Zernike Institute for Advanced Materials, University of Groningen, Groningen, The Netherlands., Bahar I; Laufer Center for Physical Quantitative Biology and Department of Biochemistry and Cell Biology, School of Medicine, Stony Brook University, New York, NY, USA., Bayir H; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA. hb2753@cumc.columbia.edu., Greenberg ML; Department of Biological Sciences, Wayne State University, Detroit, MI, USA. mgreenberg@wayne.edu.

Publikováno v: Nature metabolism [Nat Metab] 2023 Dec; Vol. 5 (12), pp. 2184-2205. Date of Electronic Publication: 2023 Nov 23.

Discovering selective antiferroptotic inhibitors of the 15LOX/PEBP1 complex noninterfering with biosynthesis of lipid mediators.

Autor: Dar HH; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260., Mikulska-Ruminska K; Department of Biophysics, Faculty of Physics Astronomy and Informatics, Institute of Physics, Nicolaus Copernicus University in Toruń, Toruń, Poland., Tyurina YY; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260., Luci DK; National Center for Advancing Translational Sciences, Rockville, MD 20892., Yasgar A; National Center for Advancing Translational Sciences, Rockville, MD 20892., Samovich SN; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260., Kapralov AA; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260., Souryavong AB; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260., Tyurin VA; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260., Amoscato AA; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260., Epperly MW; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15260., Shurin GV; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260., Standley M; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064., Holman TR; Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064., St Croix CM; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15260., Watkins SC; Department of Cell Biology, University of Pittsburgh, Pittsburgh, PA 15260., VanDemark AP; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260., Rana S; National Center for Advancing Translational Sciences, Rockville, MD 20892., Zakharov AV; National Center for Advancing Translational Sciences, Rockville, MD 20892., Simeonov A; National Center for Advancing Translational Sciences, Rockville, MD 20892., Marugan J; National Center for Advancing Translational Sciences, Rockville, MD 20892., Mallampalli RK; Department of Internal Medicine, The Ohio State University, Columbus, OH 43210., Wenzel SE; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260., Greenberger JS; Department of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA 15260., Rai G; National Center for Advancing Translational Sciences, Rockville, MD 20892., Bayir H; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260.; Department of Pediatrics, Division of Critical Care and Hospital Medicine, Redox Health Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032., Bahar I; Laufer Center for Physical Quantitative Biology and Department of Biochemistry and Cell Biology, School of Medicine, Stony Brook University, NY 11794., Kagan VE; Department of Environmental and Occupational Health, Center for Free Radical and Antioxidant Health, University of Pittsburgh, Pittsburgh, PA 15260.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Jun 20; Vol. 120 (25), pp. e2218896120. Date of Electronic Publication: 2023 Jun 16.

Syrian hamsters as a model of lung injury with SARS-CoV-2 infection: Pathologic, physiologic, and detailed molecular profiling.

Autor: Bednash JS; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio. Electronic address: joseph.bednash@osumc.edu., Kagan VE; Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania., Englert JA; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio., Farkas D; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio., Tyurina YY; Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania., Tyurin VA; Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania., Samovich SN; Center for Free Radical and Antioxidant Health, Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania., Farkas L; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio., Elhance A; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio., Johns F; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio., Lee H; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio., Cheng L; Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio., Majumdar A; Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio., Jones D; The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio., Mejia OR; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio., Ruane-Foster M; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio., Londino JD; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio., Mallampalli RK; Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University, Columbus, Ohio., Robinson RT; Department of Microbial Infection and Immunity, The Ohio State University, Columbus, Ohio. Electronic address: richard.robinson@osumc.edu.

Publikováno v: Translational research : the journal of laboratory and clinical medicine [Transl Res] 2022 Feb; Vol. 240, pp. 1-16. Date of Electronic Publication: 2021 Nov 02.

Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure.

Autor: Vats K; Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Kruglov O; Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Mizes A; School of Medicine, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Samovich SN; Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Amoscato AA; Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Tyurin VA; Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Tyurina YY; Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Kagan VE; Center for Free Radical and Antioxidant Health, Department of Environmental Health and Occupational Health, University of Pittsburgh, Pittsburgh, PA, 15213, USA., Bunimovich YL; Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, 15213, USA; Hillman Cancer Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, 15213, USA. Electronic address: bunimovichyl@upmc.edu.

Publikováno v: Redox biology [Redox Biol] 2021 Nov; Vol. 47, pp. 102143. Date of Electronic Publication: 2021 Sep 25.