Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sammy Yuan"'
Autor:
Joseph Ficek, Eleftheria Kalaitzaki, Shuai Sammy Yuan, Alessandra Tosolini, Ling Du, Brandon E Kremer, Katherine Davy, Helen Zhou, Tai-Tsang Chen
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 23:e213-e221
Autor:
Linchen He, Yuru Ren, Han Chen, Daphne Guinn, Deepak Parashar, Cong Chen, Shuai Sammy Yuan, Valeriy Korostyshevskiy, Robert A. Beckman
Basket trials pool histologic indications sharing molecular pathophysiology, improving development efficiency. Currently, basket trials have been confirmatory only for exceptional therapies. Our previous randomized basket design may be generally suit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bb4f4c6bd74c2046444dd6c1bf27a2
http://wrap.warwick.ac.uk/163406/7/WRAP-Efficiency-randomized-confirmatory-basket-trial-design-family-wise-error-rate-2022.pdf
http://wrap.warwick.ac.uk/163406/7/WRAP-Efficiency-randomized-confirmatory-basket-trial-design-family-wise-error-rate-2022.pdf
Publikováno v:
Cancer Research. 83:1041-1041
Background: Previous studies have shown that ctDNA MR defined by 50% reduction of ctDNA levels after immune checkpoint inhibitor (ICI) treatment is significantly associated with improved survival. However, discordance between MR and radiologic respon
Autor:
Josh Chen, Soo Peter Ouyang, William Wang, Paul Gallo, Weining Z. Robieson, Yoko Tanaka, Bruce Binkowitz, Lanju Zhang, Sammy Yuan, Hui Quan, Gang Li, Gordon Lan
Publikováno v:
Simultaneous Global New Drug Development ISBN: 9781003109785
Simultaneous Global New Drug Development
Simultaneous Global New Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b393b38b957fcf0b7fef84aa9df2572
https://doi.org/10.1201/9781003109785-9
https://doi.org/10.1201/9781003109785-9
Autor:
Linchen He, Daphne Guinn, Robert A. Beckman, Yuru Ren, Shuai Sammy Yuan, Han Chen, Cong Chen, Valeriy R. Korostyshevskiy, Deepak Parashar
PURPOSEMolecular oncology determines biomarker-defined niche indications. Basket trials pool histologic indications sharing molecular pathophysiology, potentially improving development efficiency. Currently basket trials have been confirmatory only f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61ed56254650eaa641cba5a78a91ef83
https://doi.org/10.1101/2020.07.22.216127
https://doi.org/10.1101/2020.07.22.216127
Publikováno v:
Contemporary clinical trials. 95
During the course of clinical development, ongoing aggregate safety monitoring and evaluation are needed to understand the evolving safety profile and to ensure effective risk-management strategies for medicinal products. CIOMS reports and global reg
Publikováno v:
Platform Trial Designs in Drug Development ISBN: 9781315167756
Platform Trial Designs in Drug Development
Platform Trial Designs in Drug Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dfecfa81fb2c4cd1995cb0832b81d20
https://doi.org/10.1201/9781315167756-17
https://doi.org/10.1201/9781315167756-17
Publikováno v:
Contemporary Clinical Trials. 99:106183
Clinical safety signal detection is of great importance in establishing the safety profile of new drugs and biologics during drug development. Bayesian hierarchical meta-analysis has proven to be a very effective method of identifying potential safet
Publikováno v:
Statistics in medicine. 38(16)
In existing benefit-risk assessment (BRA) methods, benefit and risk criteria are usually identified and defined separately based on aggregated clinical data and therefore ignore the individual-level differences as well as the association among the cr
Autor:
Li, Gang, Quan, Hui, Lan, Gordon, Ouyang, Soo Peter, Chen, Fei, Weining Robieson, Wang, William, Binkowitz, Bruce, Shuai Sammy Yuan, Tanaka, Yoko, Chen, Josh, Nobushige Matsuoka, Lanju Zhang, Yang, Song, Gallo, Paul
Supplement_Inconsistency_Examples_26Jun for Lessons Learned From Multi-regional Trials With Signals of Treatment Effect Heterogeneity by Gang Li, Hui Quan, Gordon Lan, Soo Peter Ouyang, Fei Chen, Weining Robieson, William Wang, Bruce Binkowitz, Shuai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a1cd781b9c0c7a451e6238aa941779