Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Sammy Weiser, Novak"'
Autor:
Manasi Iyer, Husniye Kantarci, Madeline H. Cooper, Nicholas Ambiel, Sammy Weiser Novak, Leonardo R. Andrade, Mable Lam, Graham Jones, Alexandra E. Münch, Xinzhu Yu, Baljit S. Khakh, Uri Manor, J. Bradley Zuchero
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Myelin is essential for rapid nerve signaling and is increasingly found to play important roles in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as sheath length are thought to precisely tune conduction
Externí odkaz:
https://doaj.org/article/edb4db5ca7254451a2a567b2d539c96f
Autor:
Sheng Miao, Lawrence Fourgeaud, Patrick G. Burrola, Shani Stern, Yuhan Zhang, Kaisa E. Happonen, Sammy Weiser Novak, Fred H. Gage, Greg Lemke
Publikováno v:
Frontiers in Neuroscience, Vol 18 (2024)
The receptor tyrosine kinase Tyro3 is abundantly expressed in neurons of the neocortex, hippocampus, and striatum, but its role in these cells is unknown. We found that neuronal expression of this receptor was markedly up-regulated in the postnatal m
Externí odkaz:
https://doaj.org/article/9dfa132aca1f49d292b45beb70f65c78
Autor:
Courtney Glavis-Bloom, Casey R. Vanderlip, Sammy Weiser Novak, Masaaki Kuwajima, Lyndsey Kirk, Kristen M. Harris, Uri Manor, John H. Reynolds
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Morphology and function of the dorsolateral prefrontal cortex (dlPFC), and corresponding working memory performance, are affected early in the aging process, but nearly half of aged individuals are spared of working memory deficits. Translationally r
Externí odkaz:
https://doaj.org/article/4fc7a61de3ca4030a6d5f7025f7fc38f
Autor:
Julie C. Savage, Marie-Kim St-Pierre, Micaël Carrier, Hassan El Hajj, Sammy Weiser Novak, Maria Gabriela Sanchez, Francesca Cicchetti, Marie-Ève Tremblay
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-18 (2020)
Abstract Background Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder that affects cognitive and motor abilities by primarily targeting the striatum and cerebral cortex. HD is caused by a mutation elongating the CAG rep
Externí odkaz:
https://doaj.org/article/d4c9d594d21444658d6b9092d1971a10
Autor:
Qian Chu, Thomas F. Martinez, Sammy Weiser Novak, Cynthia J. Donaldson, Dan Tan, Joan M. Vaughan, Tina Chang, Jolene K. Diedrich, Leo Andrade, Andrew Kim, Tong Zhang, Uri Manor, Alan Saghatelian
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Cells trigger an unfolded protein response (UPR) in the endoplasmic reticulum, but its regulation by mitochondria is unclear. Here, the authors report a 54-residue microprotein PIGBOS that participates in inter-organelle contact between the endoplasm
Externí odkaz:
https://doaj.org/article/88ad530f1b6144599a5346421f1a1e1d
Autor:
Nazma Malik, Bibiana I. Ferreira, Pablo E. Hollstein, Stephanie D. Curtis, Elijah Trefts, Sammy Weiser Novak, Jingting Yu, Rebecca Gilson, Kristina Hellberg, Lingjing Fang, Arlo Sheridan, Nasun Hah, Gerald S. Shadel, Uri Manor, Reuben J. Shaw
Publikováno v:
Science. 380
Cells respond to mitochondrial poisons with rapid activation of the adenosine monophosphate–activated protein kinase (AMPK), causing acute metabolic changes through phosphorylation and prolonged adaptation of metabolism through transcriptional effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c60372c6d0433474cdd1b48556a27a96
https://doi.org/10.1126/science.abj5559
https://doi.org/10.1126/science.abj5559
Autor:
Tai Chaiamarit, Adriaan Verhelle, Romain Chassefeyre, Nandini Shukla, Sammy Weiser Novak, Leonardo R. Andrade, Uri Manor, Sandra E. Encalada
Publikováno v:
bioRxiv
Dystrophic axons comprising misfolded mutant prion protein (PrP) aggregates are a characteristic pathological feature in the prionopathies. These aggregates form inside endolysosomes -called endoggresomes-, within swellings that line up the length of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebb4414756a708c4cc4a835bf1e2ebd7
https://europepmc.org/articles/PMC10055262/
https://europepmc.org/articles/PMC10055262/
Autor:
Laura E. Newman, Nimesha Tadepalle, Sammy Weiser Novak, Cara R. Schiavon, Gladys R. Rojas, Joshua A. Chevez, Ian Lemersal, Michaela Medina, Sienna Rocha, Christina G. Towers, Danielle A. Grotjahn, Uri Manor, Gerald S. Shadel
Maternally inherited mitochondrial DNA (mtDNA) encodes essential subunits of the mitochondrial oxidative phosphorylation system, but is also a major damage-associated molecular pattern (DAMP) that engages innate immune sensors when released into the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6e32605153d15cac987f11c1bf0c106
https://doi.org/10.1101/2022.10.12.511955
https://doi.org/10.1101/2022.10.12.511955
Autor:
Kathleen DelGiorno, Zhibo Ma, Nikki Lytle, Bob Chen, Nidhi Jyotsana, Sammy Weiser Novak, Charles Cho, Leah Caplan, Olivia Ben‐Levy, Abigail Neininger, Dylan Burnette, Vincent Trinh, Marcus Tan, Uri Manor, Jason Mills, James Goldenring, Ken Lau, Geoffrey Wahl
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72db756de53a60a3b741d55f054c5d2d
https://doi.org/10.1096/fasebj.2022.36.s1.0i661
https://doi.org/10.1096/fasebj.2022.36.s1.0i661
Publikováno v:
Curr Opin Cell Biol
Tuft cells are sentinel chemosensory cells that monitor the lumen of hollow organs for noxious or infectious stimuli and respond with disease- and tissue-specific effectors. The discovery of critical tuft cell functions in intestinal type 2 immune re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c9b35f9ef7084c0f970075bb609c55
https://europepmc.org/articles/PMC9187611/
https://europepmc.org/articles/PMC9187611/