Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sammy Metobo"'
Autor:
Catherine E. Gleason, Pablo D. Garcia, Ranya Odeh, Frances Hamkins-Indik, Daphne He, Meisam Nosrati, Gavin Situ, Roberta Sala, Bernard Levin, Li-Fen Liu, Evelyn W. Wang, Siegfried Leung, Breena Fraga, Andrew T. Bockus, Justin Shapiro, Nathan Dupper, Chinmay Bhatt, Kai Yang, Megan DeMart, Sammy Metobo, James Aggen, Peadar Cremin, Ramesh Bambal, Constantine Kreatsoulas, David J. Earp, Rajinder Singh
Publikováno v:
Cancer Research. 83:1560-1560
RB and E2F genes are frequently altered in cancer. Cyclin/Cdk (cyclin-dependent kinase) complexes regulate the activity of RB and E2F to drive cell cycle progression and ensure fidelity of DNA replication. A critical subset of their substrates (Rb, E
Autor:
Wanchi Fung, Kobayashi Tetsuya, Anita Niedziela-Majka, Bob Jiang, Kim Jordan, Saritha Kusam, David G. Breckenridge, Hai Yang, Britton Kenneth Corkey, Kristyna Elbel, Chin Tay, Elaine Kan, Sammy Metobo, David Sperandio, Du Jinfa, Richard M. Neve, Sophia L. Shevick, Eric B. Lansdon, Kerim Babaoglu, Gregory Chin, Heather Webb, Debi Jin, Annapurna Sapre, Vangelis Aktoudianakis, Latesh Lad, Jamie Bates, Xiaowu Chen, Jeff Zablocki, Gene Eisenberg, Nate Larson, Richard L. Mackman, Martinez Ruben, Magdeleine Hung, Zachary Newby, Mish Michael R
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:457-469
The bromodomain and extra-terminal (BET) family of proteins, consisting of the bromodomains containing protein 2 (BRD2), BRD3, BRD4, and the testis-specific BRDT, are key epigenetic regulators of gene transcription and has emerged as an attractive ta
Autor:
Todd Appleby, Martijn Fenaux, Thomas Butler, Mark Charles Whitcomb, Gregory Chin, Rick Lee, Gabriel Birkus, Aesop Cho, Michael O'neil Hanrahan Clarke, Thorsten A. Kirschberg, Darius Babusis, Vangelis Aktoudianakis, Lijun Zhang, Thomas E. Edwards, Eisuke Murakami, Jie Xu, Choung U. Kim, Daniel Byun, Neil H. Squires, Edward Doerffler, Willard Lew, Adrian S. Ray, Joy Y. Feng, Ona Barauskas, Sammy Metobo, Ting Wang, Huiling Yang, Yeojin Park, Mish Michael R, Neeraj Tirunagari, Hong Ye
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:1840-1847
A series of 2′-fluorinated C -nucleosides were prepared and tested for anti-HCV activity. Among them, the triphosphate of 2′-fluoro-2′- C -methyl adenosine C -nucleoside ( 15 ) was a potent and selective inhibitor of the NS5B polymerase and mai
Autor:
Choung U. Kim, Sammy Metobo, Haolun Jin, Salman Y. Jabri, Jared W. Evans, Evangelos Aktoudianakis
Publikováno v:
Tetrahedron Letters. 54:6782-6784
We report a study of the influence of Lewis acids upon the regioselectivity of ring opening of quinolinic[2,3]anhydrides to provide 2-(isopropoxycarbonyl)-nicotinic acids. In the presence of stoichiometric amounts of indium trifluoromethanesulfonate
Autor:
Manuel Tsiang, Matthew R. Wright, Choung U. Kim, Salman Y. Jabri, Sammy Metobo, Haolun Jin, Xiaowu Chen, Mish Michael R, Rachael A. Lansdown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1187-1190
A series of C3 halobenzyl-substituted tricyclic HIV integrase inhibitors was prepared. Improvement in cell-based inhibitor potency was observed in comparison to previously disclosed tricyclic pyrroloquinolines carrying the ‘halobenzyl tail’ at th
Autor:
Choung U. Kim, Richard W. Pastor, Matthew R. Wright, Haolun Jin, Salman Y. Jabri, Peter Pyun, Sammy Metobo, Rachael A. Lansdown, Manuel Tsiang, Ruby Cai, Xiaowu Chen, Mish Michael R
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1388-1391
A series of C5-aza tricyclic HIV integrase inhibitors was prepared. A highly potent and orally bioavailable compound (compound 9) was identified and selected for development.
Autor:
Evangelos Aktoudianakis, Choung U. Kim, Oliver L. Saunders, Jie Xu, Sammy Metobo, Thomas Butler, Aesop Cho
Publikováno v:
Tetrahedron Letters. 53:484-486
Several 1′-substituted analogs of Tubercidin C-nucleosides were prepared using a highly convergent synthesis. Good to high diastereoselectivity was achieved using a variety of nucleophiles targeting the 1′-position. The source for this stereosele
Autor:
S. Pflanz, Dhivya Ramakrishnan, Jim Zheng, Simon P. Fletcher, G. Lee, Stephane Daffis, Richard L. Mackman, Sammy Metobo, William E. Delaney, Christian R. Frey, Vangelis Aktoudianakis, G. Chin, H. Yu, Mish Michael R, H.-J. Pyun, Adam Palazzo, Rita Santos, Congrong Niu
Publikováno v:
Journal of Hepatology. 66:S694
Autor:
Jared W. Evans, Choung U. Kim, Evangelos Aktoudianakis, Haolun Jin, Salman Y. Jabri, Sammy Metobo
Publikováno v:
ChemInform. 45
We report a study of the influence of Lewis acids upon the regioselectivity of ring opening of quinolinic[2,3]anhydrides to provide 2-(isopropoxycarbonyl)-nicotinic acids. In the presence of stoichiometric amounts of indium trifluoromethanesulfonate
Publikováno v:
Phosphorus, Sulfur, and Silicon and the Related Elements. 176:29-47
The preparation of the chiral uinylsulfonium salts 4, 5, and 6 is described. Their use in an annulation with 2-indolecarboxaldehyde and sodium azide proceeds to form the azido alcohol 2 with low asymmetic induction. These results represent an initial