Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Samit K. Bhattacharya"'
Autor:
Rachel J. Roth Flach, Eliza Bollinger, Allan R. Reyes, Brigitte Laforest, Bethany L. Kormos, Shenping Liu, Matthew R. Reese, Luis A. Martinez Alsina, Leanne Buzon, Yuan Zhang, Bruce Bechle, Amy Rosado, Parag V. Sahasrabudhe, John Knafels, Samit K. Bhattacharya, Kiyoyuki Omoto, John C. Stansfield, Liam D. Hurley, LouJin Song, Lina Luo, Susanne B. Breitkopf, Mara Monetti, Teresa Cunio, Brendan Tierney, Frank J. Geoly, Jake Delmore, C. Parker Siddall, Liang Xue, Ka N. Yip, Amit S. Kalgutkar, Russell A. Miller, Bei B. Zhang, Kevin J. Filipski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Branched chain amino acid (BCAA) catabolic impairments have been implicated in several diseases. Branched chain ketoacid dehydrogenase (BCKDH) controls the rate limiting step in BCAA degradation, the activity of which is inhibited by BCKDH k
Externí odkaz:
https://doaj.org/article/f9d9823491ce46a3808353f3a122b4ab
Autor:
John L. Jakubczak, Kwansik Yoon, Donn Wishka, Konstantinos Tsaparikos, Chunyan Su, Stefan J. Steyn, Ann Marie Rossi, Leslie Pustilnik, Ingrid Pruimboom-Brees, James D. Moyer, Gerrit Los, Kenneth Hook, Amy Jakowski, Erling O. Emerson, James G. Christensen, Kevin Coleman, Bruce D. Cohen, David Briere, Samit K. Bhattacharya, Vincent Bernardo, Joel Arcari, Jitesh P. Jani
The Aurora family of highly related serine/threonine kinases plays a key role in the regulation of mitosis. Aurora1 and Aurora2 play important but distinct roles in the G2 and M phases of the cell cycle and are essential for proper chromosome segrega
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12678228327716bf4df25c5faa96e884
https://doi.org/10.1158/1535-7163.c.6531558.v1
https://doi.org/10.1158/1535-7163.c.6531558.v1
Autor:
Shenping Liu, Bethany L. Kormos, John D. Knafels, Parag V. Sahasrabudhe, Amy Rosado, Ruth F. Sommese, Allan R. Reyes, Jessica Ward, Rachel J. Roth Flach, Xiaochun Wang, Leanne M. Buzon, Matthew R. Reese, Samit K. Bhattacharya, Kiyoyuki Omoto, Kevin J. Filipski
Publikováno v:
Journal of Biological Chemistry. 299:102959
Autor:
Brian, Raymer, Samit K, Bhattacharya
Publikováno v:
Journal of medicinal chemistry. 61(23)
Lead-like drugs, or drugs below molecular weight 300, are an important and sometimes overlooked component of the current pharmacopeia and contemporary medicinal chemistry practice. To examine the recent state-of-the-art in lead-like drug discovery, w
Autor:
Samuel J. Danishefsky, Xiao-Tao Chen, Bishan Zhou, Clare E. Gutteridge, and Thomas R. R. Pettus, Samit K. Bhattacharya
Publikováno v:
Journal of the American Chemical Society. 121:6563-6579
The total synthesis of the title compound (1), starting with (R)-(−)-α-phellandrene (6), has been accomplished. The synthesis rigorously proves the relative stereochemical relationship of the diterpenoid and carbohydrate domains of eleutherobin. K
Publikováno v:
Tetrahedron Letters. 40:3313-3316
The conversion of3 to6 is accomplished in high yields in three steps. The sequence greatly simplifies access to eleutherobin1. The conversion of7 to6 is accomplished in high yields in two steps. The sequence greatly simplifies access to eleutherobin.
Autor:
Samit K. Bhattacharya, Clare E. Gutteridge, Thomas R. R. Pettus, Samuel J. Danishefsky, Xiao Tao Chen, Bishan Zhou
Publikováno v:
Angewandte Chemie International Edition. 37:789-792
An "sp2 -sp3 Stille coupling" of the vinyl triflate 1 and the stannyl compound 2 is a key step toward the completion of the total synthesis of eleutherobin, a natural product exhibiting taxol-like cytotoxic activity.
Autor:
Thomas R. R. Pettus, Samuel J. Danishefsky, Clare E. Gutteridge, Bishan Zhou, Samit K. Bhattacharya, Xiao-Tao Chen
Publikováno v:
Angewandte Chemie. 110:835-838
Publikováno v:
Tetrahedron Letters. 37:8069-8072
The synthesis of the tricyclic ring system of the taxane diterpenes via an A→ABC intramolecular Diels-Alder construction, and the elaboration of the cycloadduct 13 to taxinine analog 17 are described.
Autor:
Jeffrey D. Winkler, Fina. Liotta, Samit K. Bhattacharya, Cladingboel David, Gavin D. Heffernan, Kelly Robert C, Robert A. Batey
Publikováno v:
Tetrahedron Letters. 36:2211-2214
The efficient conversion of R-(+)-verbenone to bicyclic lactone 6 , a potentially useful intermediate for the synthesis of taxanes, is described. The introduction of C-1 (taxane numbering) oxygen functionality is also reported, thereby completing the