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pro vyhledávání: '"Samira Yitiz"'
Autor:
J. Matthew Ragle, Christine Guthrie, Megan Mayerle, Sol Katzman, Samira Yitiz, Lucero E Rogel, Alan M. Zahler, Cameron M. Soulette, Andrea Ramirez
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 6
Pre-mRNA splicing must occur with extremely high fidelity. Spliceosomes assemble onto pre-mRNA guided by specific sequences (5′ splice site, 3′ splice site, and branchpoint). When splice sites are mutated, as in many hereditary diseases, the spli
Autor:
Marissa L Glover, Sol Katzman, James Matthew Ragle, Samira Yitiz, Lucero E Rogel, Alan M. Zahler
Publikováno v:
RNA. 24:1314-1325
The tri-snRNP 27K protein is a component of the human U4/U6-U5 tri-snRNP and contains an N-terminal phosphorylated RS domain. In a forward genetic screen in C. elegans, we previously identified a dominant mutation, M141T, in the highly-conserved C-te