Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda

Autor: Samira Joussef-Piña, Immaculate Nankya, Sophie Nalukwago, Joy Baseke, Sandra Rwambuya, Dane Winner, Fred Kyeyune, Keith Chervenak, Bonnie Thiel, Robert Asaad, Curtis Dobrowolski, Benjamin Luttge, Blair Lawley, Cissy M. Kityo, W. Henry Boom, Jonathan Karn, Miguel E. Quiñones-Mateu

Publikováno v: Retrovirology, Vol 19, Iss 1, Pp 1-20 (2022)

Abstract Background Our understanding of the peripheral human immunodeficiency virus type 1 (HIV-1) reservoir is strongly biased towards subtype B HIV-1 strains, with only limited information available from patients infected with non-B HIV-1 subtypes

Externí odkaz: https://doaj.org/article/8163d2795d46469d98e497b22a223b34

Nanoscale flow cytometry reveals interpatient variability in HIV protease activity that correlates with viral infectivity and identifies drug-resistant viruses

Autor: Miguel E. Quiñones-Mateu, Lauren E Lapointe, Samira Joussef-Piña, Michał M. Bonar, John C. Tilton, Jake A Galiatsos, Aiman A. Haqqani, Caroline O. Tabler

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports

HIV encodes an aspartyl protease that is activated during, or shortly after, budding of viral particles from the surface of infected cells. Protease-mediated cleavage of viral polyproteins is essential to generating infectious viruses, a process know

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5f47d77af301ab8888162315591f9a5
http://link.springer.com/article/10.1038/s41598-020-75118-1

Tapering Courses of Oral Vancomycin Induce Persistent Disruption of the Microbiota That Provide Colonization Resistance to Clostridium difficile and Vancomycin-Resistant Enterococci in Mice

Autor: Michelle M. Nerandzic, Curtis J. Donskey, Brigid Wilson, Myreen E. Tomas, Thriveen S.C. Mana, Miguel E. Quiñones-Mateu, Samira Joussef-Piña

Vancomycin taper regimens are commonly used for the treatment of recurrent Clostridium difficile infections. One rationale for tapering and pulsing of the dose at the end of therapy is to reduce the selective pressure of vancomycin on the indigenous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49100f822937e087519d1cb7db5778fb
https://europepmc.org/articles/PMC5923165/

Reduced and highly diverse peripheral HIV-1 reservoir in virally suppressed patients infected with non-B HIV-1 strains in Uganda.

Autor: Joussef-Piña, Samira¹ (AUTHOR), Nankya, Immaculate² (AUTHOR), Nalukwago, Sophie² (AUTHOR), Baseke, Joy² (AUTHOR), Rwambuya, Sandra² (AUTHOR), Winner, Dane¹ (AUTHOR), Kyeyune, Fred² (AUTHOR), Chervenak, Keith³ (AUTHOR), Thiel, Bonnie³ (AUTHOR), Asaad, Robert³ (AUTHOR), Dobrowolski, Curtis¹ (AUTHOR), Luttge, Benjamin¹ (AUTHOR), Lawley, Blair⁴ (AUTHOR), Kityo, Cissy M.² (AUTHOR), Boom, W. Henry^2,3 (AUTHOR), Karn, Jonathan^1,2 (AUTHOR), Quiñones-Mateu, Miguel E.^2,4,5 (AUTHOR) miguel.quinones-mateu@otago.ac.nz

Publikováno v: Retrovirology. 1/15/2022, Vol. 19 Issue 1, p1-20. 20p.