Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Samira Benzaria"'
Autor:
Jean-Pierre Sommadossi, Michel Liuzzi, Samira Benzaria-Prad, Anna Giulia Loi, Jerome Peyronnet, Claire Pierra, Dominique Louis Nestor Ghislain Surleraux, Gwenaëlle Sizun, Gilles Gosselin, Maria Seifer, Chiara Musiu, Eric Badaroux, Céline Rabeson, David Standring
Publikováno v:
Future Medicinal Chemistry. 7:1675-1700
Background: Ribonucleoside analogs possessing a β-methyl substituent at the 2′-position of the d-ribose moiety have been previously discovered to be potent and selective inhibitors of hepatitis C virus (HCV) replication, their triphosphates acting
Autor:
Victor E. Marquez, Peter M. Blumberg, Ji-Hye Kang, Samira Benzaria, Dina M. Sigano, Nancy E. Lewin, Megan L. Peach, Yongmei Pu
Publikováno v:
Journal of Medicinal Chemistry. 49:3185-3203
Diacylglycerol lactones (DAG-lactones) are known to operate as effective agonists of protein kinase C (PKC), surpassing in potency the activity of natural diacylglycerol (DAG). Localization of activated PKC isozymes in the cell is determined in part
Autor:
Agnès Amador, A. Moussa, Richard Storer, Gilles Gosselin, Séverine Mathieu, Claire Pierra, Samira Benzaria
Publikováno v:
Nucleosides, Nucleotides and Nucleic Acids
Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2005, 24, pp.767-770
Nucleosides, Nucleotides and Nucleic Acids, Taylor & Francis, 2005, 24, pp.767-770
In order to improve the oral bioavailability of 2′-C-methylcytidine, a potent anti-HCV agent, the corresponding 3′-O-L-valinyl ester derivative (NM 283) has been synthesized. Based on its ease of synthesis and its physicochemical properties, NM 2
Autor:
Jean-Pierre Sommadossi, Anna Giulia Loi, Samira Benzaria, John Mao, Paolo La Colla, Claire Pierra, Gilles Gosselin, David Dukhan, Edward G. Bridges, D.N. Standring
Publikováno v:
Antiviral Chemistry and Chemotherapy. 15:269-279
β-L-2′-Deoxycytidine (β-L-dC) is a potent, selective and specific anti-hepatitis B virus (HBV) agent. To improve its oral bioavailability, several derivatives involving sugar or base acylation, as well as N4-derivatization with an N,N-(dimethyl-a
Autor:
Larry L. Pearce, Kee-Chung Han, Jeewoo Lee, Shunqi Yan, Ji-Hye Kang, Marc C. Nicklaus, Samira Benzaria, Peter M. Blumberg, Victor E. Marquez, Nancy E. Lewin
Publikováno v:
Journal of Medicinal Chemistry. 44:4309-4312
An approach to reduce the log P in a series of diacylglycerol (DAG)-lactones known for their high binding affinity for protein kinase C (PK-C) is presented. Branched alkyl groups with reduced lipophilicity were selected and combined with the replacem
Autor:
Victor E. Marquez, Peter M. Blumberg, Jeewoo Lee, Samira Benzaria, George W. A. Milne, Bruno Bienfait, Ravij Sharma, Shaomeng Wang, Kassoum Nacro, Kelly Teng, Nancy E. Lewin
Publikováno v:
Pharmacology & Therapeutics. 82:251-261
The pharmacophore-guided approach used in the first phase of the design of novel protein kinase C (PKC) ligands was based on the study of the geometry of bioequivalent pharmacophores present in diacylglycerol (DAG) and in the more potent phorbol este
Autor:
Shaomeng Wang, Peter M. Blumberg, Maryam Beheshti, Victor E. Marquez, Nancy E. Lewin, Samira Benzaria, Bruno Bienfait, Kassoum Nacro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:3403-3408
The binding mode of DAG-lactones to PK-C was investigated using the C1b domain from the X-ray structure of the phorbol ester/C1b complex of PK-Cδ as a template. Modeling experiments revealed two binding alternatives in which one of the carbonyls of
Autor:
G. Valette, Pieter Annaert, P. Augustijns, Jean Louis Imbach, Alain Pompon, Gilles Gosselin, Renaat Kinget, Samira Benzaria, Lieve Naesens, Sigrid Hatse, E. De Clercq, G. Van den Mooter
Publikováno v:
Pharmaceutical Research. 15:239-245
Purpose. To evaluate the potential of several bis-ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA, adefovir) to enhance the oral absorption of PMEA.
Autor:
Jean-Noël Volle, Bénédicte Dayde, David Virieux, Samira Benzaria, Dominique Surleraux, Jean-Luc Pirat, Gilles Gosselin, Claire Pierra
Publikováno v:
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10, pp.3448-3454. ⟨10.1039/c2ob25131k⟩
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2012, 10, pp.3448-3454. ⟨10.1039/c2ob25131k⟩
International audience; A 6-step procedure was developed for the synthesis of a new family of acyclic nucleoside phosphonates (ANPs), "PHEEPA" [(2-pyrimidinyl-2-(2-hydroxyethoxy)ethyl)phosphonic acids] in overall yields ranging from 4.5% to 32%. Thes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::609a80c0e49518b4bb9e00ff10a5a1ac
https://hal.archives-ouvertes.fr/hal-00993912
https://hal.archives-ouvertes.fr/hal-00993912
Autor:
André Kirn, Gilles Gosselin, Christian Pericaud, Samira Benzaria, Jean Louis Imbach, Helene Pelicano, Jean Luc Girardet, Anne Marie Aubertin, Georges Maury
Publikováno v:
Biochemical Pharmacology. 48:11-14
It is shown that ddA bis(SATE)phosphotriester is one of the most potent anti-HIV agents in cell culture. Compared with the parent nucleoside, ddA, an increase of 3 orders of magnitude was observed in the EC50, which makes this compound as active as A