Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Samir P. Patel"'
Autor:
Meagan S. Kingren, Alexander R. Keeble, Alyson M. Galvan-Lara, Jodi M. Ogle, Zoltán Ungvári, Daret K. St Clair, Timothy A. Butterfield, Allison M. Owen, Christopher S. Fry, Samir P. Patel, Hiroshi Saito
Publikováno v:
Molecular Medicine, Vol 30, Iss 1, Pp 1-17 (2024)
Abstract Background Sepsis, mainly caused by bacterial infections, is the leading cause of in-patient hospitalizations. After discharge, most sepsis survivors suffer from long-term medical complications, particularly chronic skeletal muscle weakness.
Externí odkaz:
https://doaj.org/article/2a5851bddea14470973d44fc590c574b
Autor:
Samantha N. Hart, Samir P. Patel, Felicia M. Michael, Peter Stoilov, Chi Jing Leow, Alvaro G. Hernandez, Ariane Jolly, Pierre de la Grange, Alexander G. Rabchevsky, Stefan Stamm
Publikováno v:
Neurotrauma Reports, Vol 3, Iss 1, Pp 105-121 (2022)
To determine molecular changes that correlate with long-term physiological changes after spinal cord injury associated with spasticity, we used a complete transection model with an injury at sacral spinal level S2, wherein tail spasms develop in rats
Externí odkaz:
https://doaj.org/article/9ae7ede5771b4a24aea0585cbbb1b15a
Autor:
Gopal V. Velmurugan, W. Brad Hubbard, Paresh Prajapati, Hemendra J. Vekaria, Samir P. Patel, Alexander G. Rabchevsky, Patrick G. Sullivan
Publikováno v:
Cells, Vol 12, Iss 10, p 1445 (2023)
The brain undergoes oxidative stress and mitochondrial dysfunction following physiological insults such as Traumatic brain injury (TBI), ischemia-reperfusion, and stroke. Pharmacotherapeutics targeting mitochondria (mitoceuticals) against oxidative s
Externí odkaz:
https://doaj.org/article/9f94aa251cc2430e9f7a742e04917022
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Traumatic spinal cord injury (SCI) leads to disruption of sensory, motor and autonomic function, and triggers structural, physiological and biochemical changes that cause reorganization of existing circuits that affect functional recovery. Propriospi
Externí odkaz:
https://doaj.org/article/6e0133b980d24590977f57ec23ef0f7a
Autor:
Nishant P. Visavadiya, Samir P. Patel, Jenna L. VanRooyen, Patrick G. Sullivan, Alexander G. Rabchevsky
Publikováno v:
Redox Biology, Vol 8, Iss C, Pp 59-67 (2016)
The present study undertook a comprehensive assessment of the acute biochemical oxidative stress parameters in both cellular and, notably, mitochondrial isolates following severe upper lumbar contusion spinal cord injury (SCI) in adult female Sprague
Externí odkaz:
https://doaj.org/article/b05368ba3a7b43f68a4e8b2c1c62f00e
Autor:
Alexander G. Rabchevsky, Samir P. Patel, Travis S. Lyttle, Khalid C. Eldahan, Christopher R. O'Dell, Yi eZhang, Phillip G. Popovich, Patrick H. Kitzman, Kevin D. Donohue
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
We recently reported that the neuropathic pain medication, gabapentin (GBP; Neurontin), significantly attenuated both noxious colorectal distension (CRD)-induced autonomic dysreflexia (AD) and tail pinch-induced spasticity compared to saline-treated
Externí odkaz:
https://doaj.org/article/fe3adb5098324e25aa4219b03caa2331
Autor:
Samir P. Patel, Felicia M. Michael, M. Arif Khan, Brian Duggan, Sam Wyse, Daniel R. Darby, Krishnaroop Chaudhuri, Jonathan T. Pham, Jenna Gollihue, Jason E. DeRouchey, Patrick G. Sullivan, Tom D. Dziubla, Alexander G. Rabchevsky
Publikováno v:
Mitochondrion
We developed a thermal-gelling, erodible hydrogel system for localized delivery of viable mitochondria in vivo, as well as labeled transplanted mitochondria with specific dyes and/or genetically modified mitochondria tagged with red fluorescence prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86f3fcbdff8a319461949621480018f
https://doi.org/10.1016/j.mito.2022.04.002
https://doi.org/10.1016/j.mito.2022.04.002
Autor:
Samir P. Patel, Felicia M. Michael, Jenna L. Gollihue, W. Brad Hubbard, Patrick G. Sullivan, Alexander G. Rabchevsky
Publikováno v:
Mitochondrion. 68
Herein, we review evidence that targeting mitochondrial dysfunction with 'mitoceuticals' is an effective neuroprotective strategy following neurotrauma, and that isolated exogenous mitochondria can be effectively transplanted into host spinal cord pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6576998dc636704ec2a07b3756471db6
https://pubmed.ncbi.nlm.nih.gov/36371072
https://pubmed.ncbi.nlm.nih.gov/36371072
Autor:
Andrew N. Stewart, Ethan P. Glaser, Caitlin A. Mott, William M. Bailey, Patrick G. Sullivan, Samir P. Patel, John C. Gensel
Publikováno v:
Journal of neurotrauma. 39(15-16)
Advanced age at the time of spinal cord injury (SCI) exacerbates damage from reactive oxygen species (ROS). Mechanisms underlying this age-dependent response are not well understood and may arise from decreased antioxidant defense. We investigated ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59194a6fa0515873b3b33b4b659e18df
https://pubmed.ncbi.nlm.nih.gov/35373589
https://pubmed.ncbi.nlm.nih.gov/35373589
Autor:
Bradley K. Taylor, Jenna L. Gollihue, Patrick G. Sullivan, Alexander G. Rabchevsky, Samir P. Patel, David H. Cox, Khalid C. Eldahan, Renee R. Donahue
Publikováno v:
Journal of Neurotrauma. 35:1800-1818
Our previous studies reported that pharmacological maintenance of mitochondrial bioenergetics after experimental spinal cord injury (SCI) provided functional neuroprotection. Recent evidence indicates that endogenous mitochondrial transfer is neuropr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4ae5c77d5653a597894afcc8da2fc8
https://doi.org/10.1089/neu.2017.5605
https://doi.org/10.1089/neu.2017.5605