Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Samir N P Kelada"'
Autor:
Eric Van Buren, Giorgia Radicioni, Sarah Lester, Wanda K O'Neal, Hong Dang, Silva Kasela, Suresh Garudadri, Jeffrey L Curtis, MeiLan K Han, Jerry A Krishnan, Emily S Wan, Edwin K Silverman, Annette Hastie, Victor E Ortega, Tuuli Lappalainen, Martijn C Nawijn, Maarten van den Berge, Stephanie A Christenson, Yun Li, Michael H Cho, Mehmet Kesimer, Samir N P Kelada
Publikováno v:
PLoS Genetics, Vol 19, Iss 6, p e1010445 (2023)
Hyper-secretion and/or hyper-concentration of mucus is a defining feature of multiple obstructive lung diseases, including chronic obstructive pulmonary disease (COPD). Mucus itself is composed of a mixture of water, ions, salt and proteins, of which
Externí odkaz:
https://doaj.org/article/15ff002556a14a7bb60b42d94e480aed
Autor:
Troy D. Rogers, Brian Button, Samir N. P. Kelada, Lawrence E. Ostrowski, Alessandra Livraghi-Butrico, Mark I. Gutay, Charles R. Esther, Barbara R. Grubb
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
As the nasal cavity is the portal of entry for inspired air in mammals, this region is exposed to the highest concentration of inhaled particulate matter and pathogens, which must be removed to keep the lower airways sterile. Thus, one might expect v
Externí odkaz:
https://doaj.org/article/8f11df437d0b4e6cbc966594a58fd2c5
Autor:
Gregory J. Smith, Adelaide Tovar, Matt Kanke, Yong Wang, Jessy S. Deshane, Praveen Sethupathy, Samir N. P. Kelada
Publikováno v:
Physiological Reports, Vol 9, Iss 18, Pp n/a-n/a (2021)
Abstract Inhalation exposure to ozone (O3) causes adverse respiratory health effects that result from airway inflammation, a complex response mediated in part by changes to airway cellular transcriptional programs. These programs may be regulated by
Externí odkaz:
https://doaj.org/article/591db62d95fa4201a077f19059949e37
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 9, Iss 5, Pp 1707-1727 (2019)
The Collaborative Cross (CC) is a mouse genetic reference population whose range of applications includes quantitative trait loci (QTL) mapping. The design of a CC QTL mapping study involves multiple decisions, including which and how many strains to
Externí odkaz:
https://doaj.org/article/a704cc196011406abb39484717513a6d
Autor:
Adelaide Tovar, Gregory J. Smith, Morgan B. Nalesnik, Joseph M. Thomas, Kathryn M. McFadden, Jack R. Harkema, Samir N. P. Kelada
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 67:528-538
Ozone (O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6047f50a08f4af806c819b616f01448
https://doi.org/10.1165/rcmb.2021-0326oc
https://doi.org/10.1165/rcmb.2021-0326oc
Autor:
Samir N. P. Kelada
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 9, Pp 2857-2865 (2016)
Allergic asthma is common airway disease that is characterized in part by enhanced airway constriction in response to nonspecific stimuli. Genome-wide association studies have identified multiple loci associated with asthma risk in humans, but these
Externí odkaz:
https://doaj.org/article/558030a7173747e8ac42d7f1a162ed7d
Autor:
Eric Van Buren, Giorgia Radicioni, Sarah Lester, Wanda K. O’Neal, Hong Dang, Silva Kasela, Suresh Garudadri, Jeffrey L. Curtis, Meilan Han, Jerry A. Krishnan, Emily S. Wan, Edwin K. Silverman, Annette Hastie, Victor E. Ortega, Tuuli Lappalainen, Stephanie A. Christenson, Yun Li, Michael H. Cho, Mehmet Kesimer, Samir N. P. Kelada
Hyper-secretion and/or hyper-concentration of mucus is a defining feature of multiple obstructive lung diseases, including chronic obstructive pulmonary disease (COPD). Mucus itself is composed of a mixture of water, ions, salt and proteins, of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969f0638ea89f00bc6e741114a8c12e0
https://doi.org/10.1101/2022.09.28.509838
https://doi.org/10.1101/2022.09.28.509838
Publikováno v:
Genetics
Multiparent populations are experimental populations generated by breeding together a genetically diverse set of inbred founder strains to produce individuals whose genomes are random mosaics of the founder haplotypes.....
Multiparental populati
Multiparental populati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d73c111812717f14cc490baae4d87bd
https://doi.org/10.1534/genetics.120.303393
https://doi.org/10.1534/genetics.120.303393
Autor:
Adelaide Tovar, Dale O. Cowley, Samir N. P. Kelada, Miriya K. Tune, Lucas T. Laudermilk, Alison K. Homstad, Kathryn M. McFadden, Jason R. Mock, Joseph M. Thomas, Folami Y. Ideraabdullah
Publikováno v:
Mamm Genome
Airway neutrophilia is correlated with disease severity in a number of chronic and acute pulmonary diseases, and dysregulation of neutrophil chemotaxis can lead to host tissue damage. The gene Zfp30 was previously identified as a candidate regulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a2c81fc0b87158b4654cccb36b1e46b
https://doi.org/10.1007/s00335-020-09847-z
https://doi.org/10.1007/s00335-020-09847-z
Autor:
Terrence S. Furey, Joseph M. Thomas, Gregory J. Smith, Wesley L. Crouse, Kathryn M. McFadden, Adelaide Tovar, Samir N. P. Kelada, Benjamin P Keith, Timothy P. Moran
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Acute ozone (O3) exposure is associated with multiple adverse cardiorespiratory outcomes, the severity of which varies across individuals in human populations and inbred mouse strains. However, molecular determinants of response, including susceptibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b378cff043ccb0d1ffe26a0b2e112819
https://pubmed.ncbi.nlm.nih.gov/34755540
https://pubmed.ncbi.nlm.nih.gov/34755540