Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Samir M. El Moghazy"'
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 32, Iss 1, Pp 176-188 (2017)
New target compounds were designed as inhibitors of tubulin polymerization relying on using two types of ring B models (cyclohexenone and indazole) to replace the central ring in colchicine. Different functional groups (R1) were attached to manipulat
Externí odkaz:
https://doaj.org/article/c2d6dbbe02d64e02b6baa7b47f4a60f3
Autor:
Walaa Hamada Abd-Allah, Mostafa Abd El-Mohsen Anwar, Eman R. Mohammed, Marawan A. Elbaset, Samir M. El Moghazy
Publikováno v:
Bioorganic Chemistry. 136:106561
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de3a21b901f2c5c2b400c6ad6b95cf8e
https://doi.org/10.1016/j.bioorg.2023.106561
https://doi.org/10.1016/j.bioorg.2023.106561
Publikováno v:
Journal of the Iranian Chemical Society. 18:1825-1837
Introduction of novel statistical technique for computing the interaction of lomefloxacin (LOME) and lanthanum (Ln) was the main purpose of this research. Moreover, using lanthanum as example of lanthanides for such interaction had not been exploited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7fce6e3a0cf1a8a4b1047d671ccdb99f
https://doi.org/10.1007/s13738-021-02162-7
https://doi.org/10.1007/s13738-021-02162-7
Publikováno v:
Journal of AOAC INTERNATIONAL. 104:355-367
Background According to literature reports, none of the previous methods of analysis had touched the multivariate approach for the quantification of significant factors affecting the interaction of dobutamine or hexoprenaline with Terbium. Objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d32cf09441e8bbd2669fe9f0897896
https://doi.org/10.1093/jaoacint/qsaa131
https://doi.org/10.1093/jaoacint/qsaa131
Publikováno v:
Bioorganic Chemistry. 87:655-666
Various pyridopyridazinone derivatives were designed as Poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors. The pyridopyridazinone scaffold was used as an isostere of the phthalazine nucleus of the lead compound Olaparib in addition to some modificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c5292013d81c11c4ecd964173886cd
https://doi.org/10.1016/j.bioorg.2019.03.068
https://doi.org/10.1016/j.bioorg.2019.03.068
Publikováno v:
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 208:114-123
A chemometrically optimized procedure has been developed for the determination of isoprenaline (ISO) in the parent substance as well as in its respective pharmaceutical preparation. It is worth mentioning that although spectroscopic determination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd5393a1f1e9d77f68a07c0b9d6c532
https://doi.org/10.1016/j.saa.2018.09.061
https://doi.org/10.1016/j.saa.2018.09.061
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 6, Pp o936-o937 (2013)
In the title compound, C20H18ClN5S, the toluene and triazole rings are oriented almost perpendicular to each other, making a dihedral angle of 89.97 (9)°, whereas the dihedral angle between cholorophenyl and pyrazole rings is 54.57 (11)°. In the cr
Externí odkaz:
https://doaj.org/article/28d834a87a2a421c974e3ee3a2286899
Publikováno v:
Acta Crystallographica Section E, Vol 69, Iss 2, Pp o295-o296 (2013)
In the title compound, C16H14ClN3O2S, the dihedral angle between the benzene and pyrazole rings is 52.75 (2)°, while that between the pyrazole and 4-chlorophenyl rings is 54.0 (3)°. The terminal sulfonamide group adopts an approximately tetrahedral
Externí odkaz:
https://doaj.org/article/2e29b63e6d76429b858ccb77789ef63e
Publikováno v:
Bioorganic chemistry. 104
Six series based on barbituric acid 5a-e, 10a-d; thiobarbituric acid 6a-e, 11a-d and 1,3-dimethylbarbituric acid 7a-e, 12a-d were prepared and screened for their in vitro PARP1 inhibition. They revealed promising inhibition at nanomolar level especia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233e11f2d75aab4e9f153d7a6477e29f
https://pubmed.ncbi.nlm.nih.gov/32920355
https://pubmed.ncbi.nlm.nih.gov/32920355
Autor:
Samir M. El-Moghazy, Hany H. Arab, Noha H. Amin, Asmaa G. Safi El-Din, Mohammed T. El-Saadi, Ahmed H. Abdelazeem
Publikováno v:
Journal of Molecular Structure. 1240:130565
Herein, two novel series of diaryl-1,2,4-triazole hybrid to amide conjugates (5a-e) or urea conjugates (10a-f) have been synthesized followed by in vitro evaluation against cyclooxygenase-2/soluble epoxide hydrolase (COX-2/sEH) enzymes using ELISA en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c253ce3288b70d6c83bdec8246284d86
https://doi.org/10.1016/j.molstruc.2021.130565
https://doi.org/10.1016/j.molstruc.2021.130565