Výsledky vyhledávání - "Samir K. Nath"

Monomeric human soluble CD4 dimerizes at physiological temperature: VTSAXS data based modeling and screening of retardant molecules

Autor: Ashish, Samir K. Nath, Kanika Dhiman

Publikováno v: Journal of biomolecular structuredynamics. 39(11)

Earlier, solution small angle X-ray scattering (SAXS) data at 10 °C showed that soluble CD4 (sCD4; 1 mg/ml) is monomer with shape similar to single chain in crystal structures of its dimer. Query remained whether the dimeric state of CD4 can form in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54bf92391a5e016b7563786c7baf8cca
https://pubmed.ncbi.nlm.nih.gov/32425101

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Low pH Overrides the Need of Calcium Ions for the Shape–Function Relationship of Calmodulin: Resolving Prevailing Debates

Autor: Simranjot Bawa, Samir K. Nath, Yogendra S. Rathore, Ashish, Neha Verma, Reema R. Dhoke, Kalpana Pandey

Publikováno v: The Journal of Physical Chemistry B. 118:5059-5074

Calmodulin (CaM) regulates numerous cellular functions by sensing Ca(2+) levels inside cells. Although its structure as a function of the Ca(2+)-bound state remains hotly debated, no report is available on how pH independently or in interaction with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77760d4127545c84ea116c20e6c3d9ee
https://doi.org/10.1021/jp501641r

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Topical Delivery of Protein and Peptide Using Novel Cell Penetrating Peptide IMT-P8

Autor: Ankur Gautam, Samir K. Nath, Priyanka Priyanka, Garima Mittal, Manisha Kumari, Gursimran Bedi, Jesse S. Samuel, Jagpreet S. Nanda, Neeraj Khatri, Gajendra P. S. Raghava

Publikováno v: Scientific Reports

Skin, being the largest organ of the body, is an important site for drug administration. However, most of the drugs have poor permeability and thus drug delivery through the skin is very challenging. In this study, we examined the transdermal deliver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c584e249df96695e5d33c71ab7b234b3

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Structural Analysis of the Myo1c and Neph1 Complex Provides Insight into the Intracellular Movement of Neph1

Autor: Pankaj Sharma, Deepak Nihalani, Waleed O. Twal, E. Michael Ostap, Ehtesham Arif, Yogendra S. Rathore, Leena Mallik, Lawrence B. Holzman, Ashish K. Solanki, Darpan Gandhi, Samir K. Nath, Ashish

The Myo1c motor functions as a cargo transporter supporting various cellular events, including vesicular trafficking, cell migration, and stereociliary movements of hair cells. Although its partial crystal structures were recently described, the stru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::629620381c96f72fb362034a6f45b0b9
https://europepmc.org/articles/PMC4959310/

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Global shape and ligand binding efficiency of the HIV-1-neutralizing antibodies differ from those of antibodies that cannot neutralize HIV-1

Autor: Deepak Nihalani, Yogendra S. Rathore, Ashish, Samir K. Nath, Reema R. Dhoke, Maulik D. Badmalia, Ashish K. Solanki

Publikováno v: The Journal of biological chemistry. 289(50)

Asymmetric disposition of Fab arms in the structures solved for the broadly neutralizing monoclonal antibody (nmAb) IgG1 b12 raised the question of whether the unusual shape observed for b12 is common for all IgG1 mAbs or if there is a difference in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527d3bd612c8ce67a84f8ad83e6e2b45
https://pubmed.ncbi.nlm.nih.gov/25331945

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Identification and characterization of novel protein-derived arginine-rich cell-penetrating peptides

Autor: Pooja Vir, Rajesh Kumar, Ankur Gautam, Samir K. Nath, Minakshi Sharma, Gajendra P. S. Raghava, Kumardeep Chaudhary, Pallavi Kapoor

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 89

Cell-penetrating peptides (CPPs) have proven their potential as an efficient delivery system due to their intrinsic ability to traverse biological membranes and transport various cargoes into the cells. In the present study, we have identified novel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39db05b190c210f1ce6e1554c8095801
https://pubmed.ncbi.nlm.nih.gov/25459448

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Squalamine, a novel cationic steroid, specifically inhibits the brush-border Na+/H+exchanger isoform NHE3

Autor: Chung-Ming Tse, M. Zasloff, Samir K. Nath, Shafinaz Akhter, Mark Donowitz, J. Williams

Publikováno v: American Journal of Physiology-Cell Physiology. 276:C136-C144

Squalamine, an endogenous molecule found in the liver and other tissues of Squalus acanthias, has antibiotic properties and causes changes in endothelial cell shape. The latter suggested that its potential targets might include transport proteins tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031c2f5dbe517f96b5affab39646b715
https://doi.org/10.1152/ajpcell.1999.276.1.c136

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Towards strain-independent anti-influenza peptides: a SAXS- and modeling-based study

Autor: Kalpana Pandey, Yogendra S. Rathore, Ashish, Samir K. Nath

Publikováno v: Journal of biomolecular structuredynamics. 32(11)

Using small angle X-ray scattering (SAXS) data, we reconstructed the scattering shape of the Hemagglutinin (HA) trimer protein from five different influenza strains. Comparison with the known crystal structures-based information aided in identifying

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcf9b13dac962c55effaae4a5d87817f
https://pubmed.ncbi.nlm.nih.gov/23998328

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