Crowd sourcing a new paradigm for interactome driven drug target identification in Mycobacterium tuberculosis.

Autor: Rohit Vashisht, Anupam Kumar Mondal, Akanksha Jain, Anup Shah, Priti Vishnoi, Priyanka Priyadarshini, Kausik Bhattacharyya, Harsha Rohira, Ashwini G Bhat, Anurag Passi, Keya Mukherjee, Kumari Sonal Choudhary, Vikas Kumar, Anshula Arora, Prabhakaran Munusamy, Ahalyaa Subramanian, Aparna Venkatachalam, S Gayathri, Sweety Raj, Vijaya Chitra, Kaveri Verma, Salman Zaheer, J Balaganesh, Malarvizhi Gurusamy, Mohammed Razeeth, Ilamathi Raja, Madhumohan Thandapani, Vishal Mevada, Raviraj Soni, Shruti Rana, Girish Muthagadhalli Ramanna, Swetha Raghavan, Sunil N Subramanya, Trupti Kholia, Rajesh Patel, Varsha Bhavnani, Lakavath Chiranjeevi, Soumi Sengupta, Pankaj Kumar Singh, Naresh Atray, Swati Gandhi, Tiruvayipati Suma Avasthi, Shefin Nisthar, Meenakshi Anurag, Pratibha Sharma, Yasha Hasija, Debasis Dash, Arun Sharma, Vinod Scaria, Zakir Thomas, OSDD Consortium, Nagasuma Chandra, Samir K Brahmachari, Anshu Bhardwaj

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e39808 (2012)

A decade since the availability of Mycobacterium tuberculosis (Mtb) genome sequence, no promising drug has seen the light of the day. This not only indicates the challenges in discovering new drugs but also suggests a gap in our current understanding

Externí odkaz: https://doaj.org/article/7f5e30f92a504d5a9a73abbdd29ca345

A role for voltage-dependent anion channel Vdac1 in polyglutamine-mediated neuronal cell death.

Autor: Tanay Ghosh, Neeraj Pandey, Arindam Maitra, Samir K Brahmachari, Beena Pillai

Publikováno v: PLoS ONE, Vol 2, Iss 11, p e1170 (2007)

Expansion of trinucleotide repeats in coding and non-coding regions of genes is associated with sixteen neurodegenerative disorders. However, the molecular effects that lead to neurodegeneration have remained elusive. We have explored the role of tra

Externí odkaz: https://doaj.org/article/6fb53803ca864467b7f24cfe9392629a

Author Correction: Parkinson’s disease and schizophrenia interactomes contain temporally distinct gene clusters underlying comorbid mechanisms and unique disease processes

Autor: Kalyani B. Karunakaran, Sanjeev Jain, Samir K. Brahmachari, N. Balakrishnan, Madhavi K. Ganapathiraju

Publikováno v: Schizophrenia, Vol 10, Iss 1, Pp 1-1 (2024)

Externí odkaz: https://doaj.org/article/0a0a34dc072946bfafc930f3f849f81b

COVID-19 and beyond: a call for action and audacious solidarity to all the citizens and nations, it is humanity’s fight

Autor: Sai-Juan Chen, Mehmet Ozturk, Michel Goldman, Denis Noble, Hiroaki Kitano, J. T. Paweska, James R. Heath, Doron Lancet, Karine Clément, Marcelo B. Soares, Mathias Uhlén, Damjana Rozman, Emiel F.M. Wouters, Christian Bréchot, Josep Roca, Ulrike Protzer, Ferran Sanz, Peter J. M. Openshaw, Olaf Wolkenhauer, Martine Laville, Antoine Magnan, Tolu Oni, Bartha Maria Knoppers, Peter J. Sterk, Ariel B. Lindner, Iruka N. Okeke, Myrna C. Bonaldo, Daria Danilenko, Alfonso Valencia, Bertrand Boutron, Rudi Balling, Samir K. Brahmachari, Andrea Gelemanovic, Sumio Sugano, Alberto Di Meglio, Edgar Morin, Jason D Goldman, Mihael H. Polymeropoulos, Christian Pristipino, Carole Goble, Sylvie van der Werf, Vincenzo Valentini, Ismail Serageldin, Laurent Nottale, Leroy Hood, Jesper Tegnér, S. Palkonen, Alfredo Cesario, Christophe Pison, Yi-Ke Guo, Andres Metspalu, Andrea Urbani, David Supple, Mark Lathrop, Laurent P. Nicod, Catherine Larue, Theresa J. Ochoa, Peter Hunter, Eran Segal, Manlio Vinciguerra, Niklas Blomberg, Lisa F. P. Ng, Helga Nowotny, Marc Santolini, Charles Auffray, Giulio Superti-Furga, Takashi Gojobori, Li Jin, Giovanni Scambia

Publikováno v: F1000Research, 9, 1-18. F1000 Research Ltd.
F1000 Res. 9:1130 (2021)
F1000Research
F1000Research, 2020, 9, pp.1130. ⟨10.12688/F1000RESEARCH.26098.1⟩
Auffray, C, Balling, R, Blomberg, N, Bonaldo, M, Boutron, B, Brahmachari, S, Bréchot, C, Cesario, A, Chen, S, Clément, K, Danilenko, D, Di Meglio, A, Gelemanovic, A, Goble, C, Gojobori, T, Goldman, J D, Goldman, M, Guo, Y, Heath, J, Hood, L, Hunter, P, Jin, L, Kitano, H, Knoppers, B M, Lancet, D, Larue, C, Lathrop, M, Laville, M, Lindner, A B, Magnan, A, Metspalu, A, Morin, E, Ng, L F P, Nicod, L, Noble, D, Nottale, L, Nowotny, H, Ochoa, T, Okeke, I, Oni, T, Openshaw, P, Oztürk, M, Palkonen, S, Paweska, J, Pison, C, Polymeropoulos, M, Pristipino, C, Protzer, U, Roca, J, Rozman, D, Santolini, M, Sanz, F, Scambia, G, Segal, E, Serageldin, I, Soares, M B, Sterk, P, Sugano, S, Superti-furga, G, Supple, D, Tegnér, J, Uhlen, M, Urbani, A, Valencia, A, Valentini, V, Van Der Werf, S, Vinciguerra, M, Wolkenhauer, O & Wouters, E 2020, ' COVID-19 and Beyond: A Call for Action and Audacious Solidarity to All the Citizens and Nations, It Is Humanity’s Fight ', SSRN Electronic Journal . https://doi.org/10.2139/ssrn.3630412

Background: SARS-CoV-2 belongs to a subgroup of coronaviruses rampant in bats for centuries. It has caused the COVID-19 pandemic. Most patients recover, but a minority of severe cases experience acute respiratory distress or an inflammatory storm dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49661daedbfe57deacbe863e704e3cc3
https://pure.amc.nl/en/publications/covid19-and-beyond(dc42081b-1d62-4bd6-a9e9-22416332dc30).html

Invariant Genes in Human Genomes

Autor: Samir K. Brahmachari, Ankit Kumar Pathak, Ashwin Kumar Jainarayanan

With large-scale human genome and exome sequencing, a lot of focus has gone in studying variations present in genomes and their associations to various diseases. Since major emphasis has been put on their variations, less focus has been given to inva

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7452b0d896bed1b1ba52eaf7281d012f