Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Samir H. Barghout"'
Autor:
Niki Esfahanian, Sze Wah Samuel Chan, Luna J. Zhan, M.Catherine Brown, Khaleeq Khan, Jae Lee, Karmugi Balaratnam, Elizabeth Yan, Jennifer Parker, Miguel Garcia-Pardo, Samir H. Barghout, Lawson Eng, Penelope A. Bradbury, Frances A. Shepherd, Natasha B. Leighl, Adrian G. Sacher, Stephanie Snow, Rosalyn Juergens, Geoffrey Liu
Publikováno v:
Cancer Treatment and Research Communications, Vol 37, Iss , Pp 100774- (2023)
Close monitoring after diagnosis of patients with stage I-III non-small cell lung cancer (NSCLC) may result in fitter patients with lower disease burden at the time of metastatic recurrence or progression compared to patients diagnosed initially as s
Externí odkaz:
https://doaj.org/article/256ce68c88ac4011887db2fadee58e0a
Autor:
Magdalena M. Szewczyk, Genna M. Luciani, Victoria Vu, Alex Murison, David Dilworth, Samir H. Barghout, Mathieu Lupien, Cheryl H. Arrowsmith, Mark D. Minden, Dalia Barsyte-Lovejoy
Publikováno v:
Redox Biology, Vol 51, Iss , Pp 102282- (2022)
Protein methyltransferase 5 (PRMT5) symmetrically dimethylates arginine residues leading to regulation of transcription and splicing programs. Although PRMT5 has emerged as an attractive oncology target, the molecular determinants of PRMT5 dependency
Externí odkaz:
https://doaj.org/article/8c9174ed85e342749dbc2bfff8c4fb40
Autor:
Samir H. Barghout, Ahmed Aman, Kazem Nouri, Zachary Blatman, Karen Arevalo, Geethu E. Thomas, Neil MacLean, Rose Hurren, Troy Ketela, Mehakpreet Saini, Moustafa Abohawya, Taira Kiyota, Rima Al-Awar, Aaron D. Schimmer
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
TAK-243 is a first-in-class inhibitor of ubiquitin-like modifier activating enzyme 1 that catalyzes ubiquitin activation, the first step in the ubiquitylation cascade. Based on its preclinical efficacy and tolerability, TAK-243 has been advanced to p
Externí odkaz:
https://doaj.org/article/d082e4930596459b8898e21f8ca1f16d
Autor:
Dana Yehudai, Sanduni U. Liyanage, Rose Hurren, Biljana Rizoska, Mark Albertella, Marcela Gronda, Danny V Jeyaraju, Xiaoming Wang, Samir H. Barghout, Neil MacLean, Thirushi P. Siriwardena, Yulia Jitkova, Paul Targett-Adams, Aaron D. Schimmer
Publikováno v:
Haematologica, Vol 104, Iss 5 (2019)
Mitochondrial DNA encodes 13 proteins that comprise components of the respiratory chain that maintain oxidative phosphorylation. The replication of mitochondrial DNA is performed by the sole mitochondrial DNA polymerase γ. As acute myeloid leukemia
Externí odkaz:
https://doaj.org/article/a3754aeeba0b4a40bc86a29f3f6df762
Autor:
Benjamin H. Lok, Geoffrey Liu, Ming S. Tsao, Aaron D. Schimmer, Rod Bremner, Joel D. Pearson, Samir H. Barghout, Vijithan Sugumar, Ranya Barayan, Jessica Weiss, Lifang Song, Fariha Rahman, Vidhyasagar Venkatasubramanian, Kevin C.J. Nixon, Mansi K. Aparnathi, Safa Majeed
Supplementary Data from Targeting the Ubiquitin–Proteasome System Using the UBA1 Inhibitor TAK-243 is a Potential Therapeutic Strategy for Small-Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dec1598a9f1c977852b1ad0084664a
https://doi.org/10.1158/1078-0432.22483878.v1
https://doi.org/10.1158/1078-0432.22483878.v1
Autor:
Benjamin H. Lok, Geoffrey Liu, Ming S. Tsao, Aaron D. Schimmer, Rod Bremner, Joel D. Pearson, Samir H. Barghout, Vijithan Sugumar, Ranya Barayan, Jessica Weiss, Lifang Song, Fariha Rahman, Vidhyasagar Venkatasubramanian, Kevin C.J. Nixon, Mansi K. Aparnathi, Safa Majeed
Purpose:Small cell lung cancer (SCLC) is an aggressive disease with an overall 5-year survival rate of less than 10%. Treatment for SCLC with cisplatin/etoposide chemotherapy (C/E) ± radiotherapy has changed modestly over several decades. The ubiqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62960533f4307a56243682fafcc1f621
https://doi.org/10.1158/1078-0432.c.6531261.v1
https://doi.org/10.1158/1078-0432.c.6531261.v1
Autor:
Safa Majeed, Mansi K. Aparnathi, Kevin C.J. Nixon, Vidhyasagar Venkatasubramanian, Fariha Rahman, Lifang Song, Jessica Weiss, Ranya Barayan, Vijithan Sugumar, Samir H. Barghout, Joel D. Pearson, Rod Bremner, Aaron D. Schimmer, Ming S. Tsao, Geoffrey Liu, Benjamin H. Lok
Publikováno v:
Clinical Cancer Research. 28:1966-1978
Purpose: Small cell lung cancer (SCLC) is an aggressive disease with an overall 5-year survival rate of less than 10%. Treatment for SCLC with cisplatin/etoposide chemotherapy (C/E) ± radiotherapy has changed modestly over several decades. The ubiqu
Autor:
Samir H. Barghout, Mandeep K. Mann, Ahmed Aman, Yifan Yu, Matthew G. Alteen, Aaron D. Schimmer, Matthieu Schapira, Cheryl H. Arrowsmith, Dalia Barsyte-Lovejoy
Publikováno v:
ACS chemical biology. 17(10)
Anticancer drug response is determined by genetic and epigenetic mechanisms. To identify the epigenetic regulators of anticancer drug response, we conducted a chemical epigenetic screen using chemical probes that target different epigenetic modulator
Autor:
Francesco Fazzari, Sue Chow, May Cheung, Samir H. Barghout, Aaron D. Schimmer, Qing Chang, David Hedley
Publikováno v:
ACS pharmacologytranslational science. 5(11)
Pancreatic ductal adenocarcinoma is characterized by increased generation of reactive oxygen species that can cause lethal oxidative stress. Here, we evaluated the combined inhibition of the glutathione and thioredoxin antioxidant systems in preclini
Publikováno v:
Biochimica et biophysica acta. Gene regulatory mechanisms. 1865(6)
Histone lysine methylation is a post-translational modification that plays a key role in the epigenetic regulation of a broad spectrum of biological processes. Moreover, the dysregulation of histone lysine methyltransferases (KMTs) has been implicate