Genome-wide determinants of mortality and motor progression in Parkinson’s disease

Autor: Manuela M. X. Tan, Michael A. Lawton, Miriam I. Pollard, Emmeline Brown, Raquel Real, Alejandro Martinez Carrasco, Samir Bekadar, Edwin Jabbari, Regina H. Reynolds, Hirotaka Iwaki, Cornelis Blauwendraat, Sofia Kanavou, Leon Hubbard, Naveed Malek, Katherine A. Grosset, Nin Bajaj, Roger A. Barker, David J. Burn, Catherine Bresner, Thomas Foltynie, Nicholas W. Wood, Caroline H. Williams-Gray, Ole A. Andreassen, Mathias Toft, Alexis Elbaz, Fanny Artaud, Alexis Brice, Jean-Christophe Corvol, Jan Aasly, Matthew J. Farrer, Michael A. Nalls, Andrew B. Singleton, Nigel M. Williams, Yoav Ben-Shlomo, John Hardy, Michele T. M. Hu, Donald G. Grosset, Maryam Shoai, Lasse Pihlstrøm, Huw R. Morris

Publikováno v: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-15 (2024)

Abstract There are 90 independent genome-wide significant genetic risk variants for Parkinson’s disease (PD) but currently only five nominated loci for PD progression. The biology of PD progression is likely to be of central importance in defining

Externí odkaz: https://doaj.org/article/b1dcf9f75c9e4bc4bc4699609e993749

A Sparse Mixture-of-Experts Model With Screening of Genetic Associations to Guide Disease Subtyping

Autor: Marie Courbariaux, Kylliann De Santiago, Cyril Dalmasso, Fabrice Danjou, Samir Bekadar, Jean-Christophe Corvol, Maria Martinez, Marie Szafranski, Christophe Ambroise

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Motivation: Identifying new genetic associations in non-Mendelian complex diseases is an increasingly difficult challenge. These diseases sometimes appear to have a significant component of heritability requiring explanation, and this missing heritab

Externí odkaz: https://doaj.org/article/6eb2b92ca8714ed199395b30c92ae611

How many patients are eligible for disease-modifying treatment in Alzheimer’s disease? A French national observational study over 5 years

Autor: Didier Hannequin, Florence Pasquier, Bruno Dubois, David Wallon, Julien Dumurgier, Stéphane Epelbaum, Thérèse Jonveaux, Annick Besozzi, Stéphane Pouponneau, Caroline Hommet, Laetitia Berly, Adrien Julian, Marc Paccalin, Julie Bellet, Claire Boutoleau-Bretonniere, Thiphaine Charriau, Olivier Rouaud, Olivier Madec, Aurélie Mouton, Renaud David, Samir Bekadar, Roxane Fabre, Walter Deberdt

Publikováno v: BMJ Open, Vol 9, Iss 6 (2019)

ObjectiveWe aimed to study the epidemiology of the prodromal and mild stages of Alzheimer’s disease (AD) patients who are eligible for clinical trials with disease-modifying therapies.SettingsWe analysed two large complementary databases to study t

Externí odkaz: https://doaj.org/article/56ea6c9e15a3480ab28e25a9c18588ae

Genome-wide determinants of mortality and clinical progression in Parkinson’s disease

Autor: Manuela MX Tan, Michael A Lawton, Miriam I Pollard, Emmeline Brown, Samir Bekadar, Edwin Jabbari, Regina H Reynolds, Hirotaka Iwaki, Cornelis Blauwendraat, Sofia Kanavou, Leon Hubbard, Naveed Malek, Katherine A Grosset, Nin Bajaj, Roger A Barker, David J Burn, Catherine Bresner, Thomas Foltynie, Nicholas W Wood, Caroline H Williams-Gray, Ole A Andreassen, Mathias Toft, Alexis Elbaz, Fanny Artaud, Alexis Brice, Jean-Christophe Corvol, Jan Aasly, Matthew J Farrer, Michael A Nalls, Andrew B Singleton, Nigel M Williams, Yoav Ben-Shlomo, John Hardy, Michele TM Hu, Donald G Grosset, Maryam Shoai, Lasse Pihlstrøm, Huw R Morris

BackgroundThere are 90 genetic risk variants for Parkinson’s disease (PD) but currently only five nominated loci for PD progression. The biology of PD progression is likely to be of central importance in defining mechanisms that can be used to deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d61c110e72cdcb040a152340e5004841
https://doi.org/10.1101/2022.07.07.22277297

Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study

Autor: Sarah Bujac, Samir Bekadar, Marc Stauch, Reinhard Schneider, Holger Froehlich, Bruno Dubois, Albert Lladó, Wassilios G. Meissner, Viktor K. Jirsa, Ina Schmitt, Cecile Gaudebout, Michael T. Heneka, Jean-Christophe Corvol, Nathan Lawless, Tamas Letoha, Aishwarya Alex Namasivayam, Grégory Operto, Anna Antonell, Johan Van der Lei, Eloi Magnin, Phil Scordis, Ana Graf, Oriol Grau, Ana Diaz, Per Svenningsson, Mircea alasam, José Luis Molinuevo, Sofia Bergström, Stephanie Carvalho, Dianne Gove, Ioanna Markaki, Stéphane Epelbaum, Lorena Rami, Raffaele Cacciaglia, Panagiota Tsitsi, Raquel Sánchez-Valle, Jean Georges, Carl-Christian Kolbe, Olivier Rascol, Ullrich Wüllner, Frederic Brosseron, Boris Labrador, Frederic rosseron, Sergio Castro-Gomez, Noemí Carranza, Pawel Tacik, Matthew Page, Jacqueline Marovac, Eicke Latz, Luc Canard, Graziella Mangone, Martin Hofmann-Apitius, Nikolaus Forgo, Beatriz Bosch, Peter Nilsson, Francesco Santarelli, Stephan Springstubbe

Publikováno v: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, Wiley, 2020, 16 (2), pp.292-304. ⟨10.1016/j.jalz.2019.07.018⟩
Alzheimer's and dementia 16(2), 292-304 (2020). doi:10.1016/j.jalz.2019.07.018
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020, 16 (2), pp.292-304. ⟨10.1016/j.jalz.2019.07.018⟩

International audience; INTRODUCTION:Multiple immunity biomarkers have been suggested as tracers of neuroinflammation in neurodegeneration. This study aimed to verify findings in cerebrospinal fluid (CSF) samples of Alzheimer's disease (AD) and Parki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf4e3529c0d47fe008092573df3f89f
https://hal.sorbonne-universite.fr/hal-02573204